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1W93
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BU of 1w93 by Molmil
Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae
Descriptor: ACETYL-COENZYME A CARBOXYLASE
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-05
Release date:2005-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
2HJW
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BU of 2hjw by Molmil
Crystal Structure of the BC domain of ACC2
Descriptor: Acetyl-CoA carboxylase 2
Authors:Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S.
Deposit date:2006-07-02
Release date:2007-07-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Proteins, 70, 2008
2C00
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BU of 2c00 by Molmil
Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa in apo form
Descriptor: BIOTIN CARBOXYLASE, SULFATE ION
Authors:Mochalkin, I.
Deposit date:2008-03-21
Release date:2008-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase.
Protein Sci., 17, 2008
3JRX
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BU of 3jrx by Molmil
Crystal structure of the BC domain of ACC2 in complex with soraphen A
Descriptor: Acetyl-CoA carboxylase 2, SORAPHEN A
Authors:Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S.
Deposit date:2009-09-09
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK.
Biochem.Biophys.Res.Commun., 391, 2010
6OI8
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BU of 6oi8 by Molmil
Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine
Descriptor: 1,2-ETHANEDIOL, 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine, Biotin carboxylase
Authors:Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
Deposit date:2019-04-09
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
J.Med.Chem., 62, 2019
5KKN
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BU of 5kkn by Molmil
Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630
Descriptor: 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2
Authors:Wang, R, Paul, D, Tong, L.
Deposit date:2016-06-22
Release date:2016-07-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
2VR1
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BU of 2vr1 by Molmil
Crystal structure of Biotin carboxylase from E. coli in complex with ATP analog, ADPCF2P.
Descriptor: BIOTIN CARBOXYLASE, CHLORIDE ION, PHOSPHODIFLUOROMETHYLPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Mochalkin, I, Waldrop, G.L.
Deposit date:2008-03-24
Release date:2008-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase.
Protein Sci., 17, 2008
5DOU
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BU of 5dou by Molmil
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:de Cima, S, Polo, L.M, Fita, I, Rubio, V.
Deposit date:2015-09-11
Release date:2015-12-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
3VA7
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BU of 3va7 by Molmil
Crystal structure of the Kluyveromyces lactis Urea Carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, GLYCEROL, KLLA0E08119p, ...
Authors:Fan, C, Xiang, S.
Deposit date:2011-12-29
Release date:2012-02-01
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction
J.Biol.Chem., 287, 2012
3JRW
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BU of 3jrw by Molmil
Phosphorylated BC domain of ACC2
Descriptor: Acetyl-CoA carboxylase 2
Authors:Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S.
Deposit date:2009-09-09
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK
Biochem.Biophys.Res.Commun., 391, 2010
6W2J
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BU of 6w2j by Molmil
CPS1 bound to allosteric inhibitor H3B-374
Descriptor: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2020-03-05
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Acs Med.Chem.Lett., 11, 2020
7ZZ4
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BU of 7zz4 by Molmil
Cryo-EM structure of "BC closed" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA
Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M.
Deposit date:2022-05-25
Release date:2022-10-12
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (2.63 Å)
Cite:CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
Nat Commun, 13, 2022
8GK8
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BU of 8gk8 by Molmil
R21A Staphylococcus aureus pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, COENZYME A, ...
Authors:Laseke, A.J, St.Maurice, M.
Deposit date:2023-03-17
Release date:2023-08-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in Staphylococcus aureus Pyruvate Carboxylase.
Biochemistry, 62, 2023
8FXI
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BU of 8fxi by Molmil
Cryo-EM structure of Stanieria sp. CphA2 in complex with ADPCP and 4x(beta-Asp-Arg)
Descriptor: 1-[(4-aminopyrimidin-5-yl)amino]-2,5-anhydro-1-deoxy-6-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]-D-allitol, 4x(beta-Asp-Arg), MAGNESIUM ION, ...
Authors:Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M.
Deposit date:2023-01-24
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
4HQ6
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BU of 4hq6 by Molmil
BC domain in the presence of citrate
Descriptor: Acetyl-CoA carboxylase 2
Authors:Heo, Y.S.
Deposit date:2012-10-25
Release date:2013-10-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Insights into the Regulation of ACC2 by Citrate
Bull.Korean Chem.Soc., 34, 2013
3HBL
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BU of 3hbl by Molmil
Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Tong, L, Yu, L.P.C.
Deposit date:2009-05-04
Release date:2009-06-30
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3BG5
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BU of 3bg5 by Molmil
Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Xiang, S, Tong, L.
Deposit date:2007-11-26
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction.
Nat.Struct.Mol.Biol., 15, 2008
2GPS
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BU of 2gps by Molmil
Crystal Structure of the Biotin Carboxylase Subunit, E23R mutant, of Acetyl-CoA Carboxylase from Escherichia coli.
Descriptor: Biotin carboxylase
Authors:Shen, Y, Chou, C.Y, Chang, G.G, Tong, L.
Deposit date:2006-04-18
Release date:2006-07-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Is dimerization required for the catalytic activity of bacterial biotin carboxylase?
Mol.Cell, 22, 2006
8FXH
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BU of 8fxh by Molmil
Cryo-EM structure of Stanieria sp. CphA2
Descriptor: RimK domain-containing protein ATP-grasp
Authors:Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M.
Deposit date:2023-01-24
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
4HNV
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BU of 4hnv by Molmil
Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yu, L.P.C, Tong, L.
Deposit date:2012-10-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
4HNT
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BU of 4hnt by Molmil
crystal structure of F403A mutant of S. aureus Pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yu, L.P.C, Tong, L.
Deposit date:2012-10-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
3HB9
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BU of 3hb9 by Molmil
Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Tong, L, Yu, L.P.C.
Deposit date:2009-05-04
Release date:2009-06-30
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HO8
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BU of 3ho8 by Molmil
Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ...
Authors:Tong, L, Yu, L.P.C.
Deposit date:2009-06-01
Release date:2009-06-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3U9T
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BU of 3u9t by Molmil
Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme
Descriptor: Methylcrotonyl-CoA carboxylase, alpha-subunit, beta-subunit
Authors:Huang, C.S, Tong, L.
Deposit date:2011-10-19
Release date:2011-12-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
Nature, 481, 2012
8HZ5
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BU of 8hz5 by Molmil
The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus
Descriptor: Biotin carboxylase
Authors:Shen, J, Wu, W, Xu, X.
Deposit date:2023-01-08
Release date:2024-01-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus
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