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6WBC
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BU of 6wbc by Molmil
Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex
Descriptor: DNA mismatch repair protein Mlh1, Importin subunit alpha-1
Authors:de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M.
Deposit date:2020-03-26
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
6K06
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BU of 6k06 by Molmil
Crystal structure of Importin-alpha and phosphomimetic GM130
Descriptor: Importin subunit alpha-1, Peptide from Golgin subfamily A member 2
Authors:Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C.
Deposit date:2019-05-05
Release date:2019-10-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.
Nat Commun, 10, 2019
6D7N
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BU of 6d7n by Molmil
Crystal structure of the W357R/W399R Importin alpha mutant
Descriptor: 1,2-ETHANEDIOL, Peroxidase,Importin subunit alpha-1
Authors:Pedersen, L.C, London, R.E, Gabel, S.A.
Deposit date:2018-04-25
Release date:2019-03-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
7UMI
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BU of 7umi by Molmil
Importin a1 bound to Cp183-CTD
Descriptor: HBV-NLS, Importin subunit alpha-1
Authors:Yang, R, Cingolani, G.
Deposit date:2022-04-07
Release date:2023-10-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core.
Sci Adv, 10, 2024
6D7M
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BU of 6d7m by Molmil
Crystal structure of the W184R/W231R Importin alpha mutant
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Peroxidase,Importin subunit alpha-1, ...
Authors:Pedersen, L.C, London, R.E, Gabel, S.A.
Deposit date:2018-04-25
Release date:2019-03-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
7VPS
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BU of 7vps by Molmil
Crystal structure of the ARM domain of C. glabrata importin alpha
Descriptor: Importin subunit alpha
Authors:Tan, L, Im, Y.J.
Deposit date:2021-10-17
Release date:2022-09-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural basis for activation of fungal sterol receptor Upc2 and azole resistance.
Nat.Chem.Biol., 18, 2022
7VPT
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BU of 7vpt by Molmil
Structure of the C. glabrata importin alpha ARM domain - Upc2 NLS fusion
Descriptor: C. glabrata importin alpha ARM domain - Upc2 NLS fusion
Authors:Tan, L, Im, Y.J.
Deposit date:2021-10-18
Release date:2022-09-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for activation of fungal sterol receptor Upc2 and azole resistance.
Nat.Chem.Biol., 18, 2022
1EE4
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BU of 1ee4 by Molmil
CRYSTAL STRUCTURE OF YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A C-MYC NLS PEPTIDE
Descriptor: KARYOPHERIN ALPHA, MYC PROTO-ONCOGENE PROTEIN
Authors:Conti, E.
Deposit date:2000-01-30
Release date:2000-03-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
Structure Fold.Des., 8, 2000
1EJY
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BU of 1ejy by Molmil
MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX
Descriptor: IMPORTIN ALPHA, NUCLEOPLASMIN NLS PEPTIDE
Authors:Fontes, M.R, Teh, T, Kobe, B.
Deposit date:2000-03-05
Release date:2000-04-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
J.Mol.Biol., 297, 2000
1EJL
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BU of 1ejl by Molmil
MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
Descriptor: IMPORTIN ALPHA, SV40 LARGE T ANTIGEN NLS PEPTIDE
Authors:Fontes, M.R, Teh, T, Kobe, B.
Deposit date:2000-03-03
Release date:2000-04-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
J.Mol.Biol., 297, 2000
1EE5
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BU of 1ee5 by Molmil
YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDE
Descriptor: KARYOPHERIN ALPHA, NUCLEOPLASMIN
Authors:Conti, E.
Deposit date:2000-01-30
Release date:2000-03-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
Structure Fold.Des., 8, 2000
6MJL
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BU of 6mjl by Molmil
Crystal structure of ChREBP NLS peptide bound to importin alpha.
Descriptor: ChREBP Peptide ASN-TYR-TRP-LYS-ARG-ARG-ILE-GLU-VAL, Importin subunit alpha-1
Authors:Jung, H, Uyeda, K.
Deposit date:2018-09-21
Release date:2019-09-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions.
Biochem.J., 477, 2020
1F59
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BU of 1f59 by Molmil
IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX
Descriptor: FXFG NUCLEOPORIN REPEATS, IMPORTIN BETA-1
Authors:Bayliss, R, Littlewood, T, Stewart, M.
Deposit date:2000-06-13
Release date:2000-08-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
Cell(Cambridge,Mass.), 102, 2000
6N88
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BU of 6n88 by Molmil
Cryo-EM structure of the Importin7:Importin beta:Histone H1.0 complex
Descriptor: Histone H1.0, Importin subunit beta-1, MGC52556 protein
Authors:Bilokapic, S, Ivic, N, Halic, M.
Deposit date:2018-11-28
Release date:2019-02-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Fuzzy Interactions Form and Shape the Histone Transport Complex.
Mol. Cell, 73, 2019
6N89
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BU of 6n89 by Molmil
Cryo-EM structure of the Importin beta:Histone H1.0 complex
Descriptor: Histone H1.0, Importin subunit beta-1
Authors:Bilokapic, S, Ivic, N, Halic, M.
Deposit date:2018-11-28
Release date:2019-02-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Fuzzy Interactions Form and Shape the Histone Transport Complex.
Mol. Cell, 73, 2019
4WV6
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BU of 4wv6 by Molmil
Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8
Descriptor: 1,2-ETHANEDIOL, Importin subunit alpha-1, Transcription initiation factor TFIID subunit 8
Authors:Trowitzsch, S.
Deposit date:2014-11-04
Release date:2015-01-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Nat Commun, 6, 2015
1T08
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BU of 1t08 by Molmil
Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3
Descriptor: Adenomatous polyposis coli protein, Beta-catenin, Beta-catenin-interacting protein 1
Authors:Ha, N.-C, Tonozuka, T, Stamos, J.L, Weis, W.I.
Deposit date:2004-04-07
Release date:2004-10-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
Mol.Cell, 15, 2004
1TH1
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BU of 1th1 by Molmil
Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
Descriptor: Adenomatous polyposis coli protein, Beta-catenin
Authors:Xing, Y, Clements, W.K, Le Trong, I, Hinds, T.R, Stenkamp, R, Kimelman, D, Xu, W.
Deposit date:2004-05-31
Release date:2004-09-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of a beta-Catenin/APC Complex Reveals a Critical Role for APC Phosphorylation in APC Function.
Mol.Cell, 15, 2004
4XZR
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BU of 4xzr by Molmil
Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh1
Descriptor: Importin subunit alpha, Inner nuclear membrane protein SRC1
Authors:Lokareddy, R.K, Cingolani, G.
Deposit date:2015-02-04
Release date:2015-06-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
Structure, 23, 2015
4YJE
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BU of 4yje by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A1
Descriptor: APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-03
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
4YJL
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BU of 4yjl by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A2
Descriptor: 1,2-ETHANEDIOL, APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-03
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
4YI0
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BU of 4yi0 by Molmil
Structure of mouse importin a1 bound to Pom121NLS
Descriptor: Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121
Authors:Lokareddy, R.K, Cingolani, G.
Deposit date:2015-02-27
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.806 Å)
Cite:Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane
To Be Published
4YK6
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BU of 4yk6 by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A4
Descriptor: APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-04
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
1V18
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BU of 1v18 by Molmil
The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated APC 20mer repeat.
Descriptor: ADENOMATOUS POLYPOSIS COLI, BETA-CATENIN
Authors:Ha, N.-C, Weis, W.I.
Deposit date:2004-04-09
Release date:2005-01-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of Phosphorylation-Dependent Binding of Apc to Beta-Catenin and its Role in Beta-Catenin Degradation
Mol.Cell, 15, 2004
1UN0
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BU of 1un0 by Molmil
Crystal Structure of Yeast Karyopherin (Importin) alpha in complex with a Nup2p N-terminal fragment
Descriptor: IMPORTIN ALPHA SUBUNIT, NUCLEOPORIN NUP2
Authors:Matsuura, Y, Lange, A, Harreman, M.T, Corbett, A.H, Stewart, M.
Deposit date:2003-09-03
Release date:2003-10-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Nup2P Function in Cargo Release and Karyopherin Recycling in Nuclear Import
Embo J., 22, 2003

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