1E24
| LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and ATP and MN2+ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, LYSINE, ... | Authors: | Desogus, G, Todone, F, Brick, P, Onesti, S. | Deposit date: | 2000-05-16 | Release date: | 2000-07-28 | Last modified: | 2011-08-24 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
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1E1T
| LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM COMPLEXED WITH THE LYSYL_ADENYLATE INTERMEDIATE | Descriptor: | ADENOSINE-5'-[LYSYL-PHOSPHATE], GLYCEROL, LYSYL-TRNA SYNTHETASE, ... | Authors: | Desogus, G, Todone, F, Brick, P, Onesti, S. | Deposit date: | 2000-05-10 | Release date: | 2000-07-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
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1E1O
| lysyl-tRNA Synthetase (LYSU) hexagonal form, complexed with lysine | Descriptor: | GLYCEROL, LYSINE, LYSYL-TRNA SYNTHETASE, ... | Authors: | Desogus, G, Todone, F, Brick, P, Onesti, S. | Deposit date: | 2000-05-09 | Release date: | 2000-07-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
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1E22
| LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and the non-hydrolysable atp analogue amp-pcp | Descriptor: | GLYCEROL, LYSINE, LYSYL-TRNA SYNTHETASE, ... | Authors: | Desogus, G, Todone, F, Brick, P, Onesti, S. | Deposit date: | 2000-05-15 | Release date: | 2000-07-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
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1EOV
| FREE ASPARTYL-TRNA SYNTHETASE (ASPRS) (E.C. 6.1.1.12) FROM YEAST | Descriptor: | ASPARTYL-TRNA SYNTHETASE | Authors: | Sauter, C, Lorber, B, Cavarelli, J, Moras, D, Giege, R. | Deposit date: | 2000-03-24 | Release date: | 2000-09-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The free yeast aspartyl-tRNA synthetase differs from the tRNA(Asp)-complexed enzyme by structural changes in the catalytic site, hinge region, and anticodon-binding domain. J.Mol.Biol., 299, 2000
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1EFW
| Crystal structure of aspartyl-tRNA synthetase from Thermus thermophilus complexed to tRNAasp from Escherichia coli | Descriptor: | ASPARTYL-TRNA, ASPARTYL-TRNA SYNTHETASE | Authors: | Briand, C, Poterszman, A, Eiler, S, Webster, G, Thierry, J.-C, Moras, D. | Deposit date: | 2000-02-10 | Release date: | 2000-06-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | An intermediate step in the recognition of tRNA(Asp) by aspartyl-tRNA synthetase. J.Mol.Biol., 299, 2000
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1EQR
| CRYSTAL STRUCTURE OF FREE ASPARTYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI | Descriptor: | ASPARTYL-TRNA SYNTHETASE, MAGNESIUM ION | Authors: | Rees, B, Webster, G, Delarue, M, Boeglin, M, Moras, D. | Deposit date: | 2000-04-06 | Release date: | 2000-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Aspartyl tRNA-synthetase from Escherichia coli: flexibility and adaptability to the substrates. J.Mol.Biol., 299, 2000
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1G51
| ASPARTYL TRNA SYNTHETASE FROM THERMUS THERMOPHILUS AT 2.4 A RESOLUTION | Descriptor: | ADENOSINE MONOPHOSPHATE, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, ASPARTYL-TRNA SYNTHETASE, ... | Authors: | Poterzsman, A, Delarue, M, Thierry, J.C, Moras, D. | Deposit date: | 2000-10-30 | Release date: | 2000-12-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Synthesis and recognition of aspartyl-adenylate by Thermus thermophilus aspartyl-tRNA synthetase. J.Mol.Biol., 244, 1994
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3M4Q
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3NEL
| Aspartyl-tRNA synthetase complexed with aspartic acid | Descriptor: | ASPARTIC ACID, Aspartyl-tRNA synthetase | Authors: | Schmitt, E, Moras, D, Moulinier, L. | Deposit date: | 2010-06-09 | Release date: | 2010-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.954 Å) | Cite: | Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation Embo J., 17, 1998
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3NEM
| Aspartyl-tRNA synthetase complexed with aspartyl adenylate | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, Aspartyl-tRNA synthetase, ... | Authors: | Schmitt, E, Moras, D, Moulinier, L. | Deposit date: | 2010-06-09 | Release date: | 2010-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation Embo J., 17, 1998
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3NEN
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5ZH4
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-7 | Descriptor: | (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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5ZH3
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6 | Descriptor: | (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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5YZX
| Crystal structure of E.coli LysU T146D mutant | Descriptor: | BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CALCIUM ION, Lysine--tRNA ligase, ... | Authors: | Fang, P, Guo, M. | Deposit date: | 2017-12-16 | Release date: | 2018-12-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli To Be Published
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5ZG8
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5ZH5
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2 | Descriptor: | (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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5ZH2
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-5 | Descriptor: | (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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6AGT
| Crystal structure of PfKRS complexed with chromone inhibitor | Descriptor: | COBALT (II) ION, FORMIC ACID, LYSINE, ... | Authors: | Yogavel, M, Sharma, A, Sharma, A, Baragana, B, Walpole, C. | Deposit date: | 2018-08-14 | Release date: | 2019-03-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6AQG
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6AQH
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6BNI
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6C86
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6CHD
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6HCU
| Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, HISTIDINE, ... | Authors: | Tamjar, J, Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H. | Deposit date: | 2018-08-16 | Release date: | 2019-04-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc.Natl.Acad.Sci.USA, 116, 2019
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