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6Z7U
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BU of 6z7u by Molmil
Myosin-II motor domain complexed with blebbistatin in a new ADP-release conformation
Descriptor: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-06-01
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Int J Mol Sci, 21, 2020
6Z7T
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BU of 6z7t by Molmil
Nucleotide-free Myosin-II motor domain
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-06-01
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Int J Mol Sci, 21, 2020
6Z47
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BU of 6z47 by Molmil
Smooth muscle myosin shutdown state heads region
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin heavy chain 11, ...
Authors:Scarff, C.A, Carrington, G, Casas Mao, D, Chalovich, J.M, Knight, P.J, Ranson, N.A, Peckham, M.
Deposit date:2020-05-22
Release date:2020-12-09
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Structure of the shutdown state of myosin-2.
Nature, 588, 2020
6YSY
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BU of 6ysy by Molmil
Skeletal Myosin bound to MPH-220, MgADP-VO4
Descriptor: (9~{S})-5-methyl-12-(4-morpholin-4-ylphenyl)-9-oxidanyl-4-thia-2,12-diazatricyclo[7.3.0.0^{3,7}]dodeca-1,3(7),5-trien-8-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Canon, L, Kikuti, C.M, Gyimesi, M, Malnasi-Csizmadia, A, Houdusse, A.
Deposit date:2020-04-23
Release date:2021-03-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.246 Å)
Cite:Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Cell, 183, 2020
6Z2S
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BU of 6z2s by Molmil
Crystal structure of adhibin analogue-bound myosin-2
Descriptor: 3,6-dibromo-1-(hydroxymethyl)carbazole, ACETATE ION, ADP METAVANADATE, ...
Authors:Ewert, W, Knoelker, H.-J, Tsiavaliaris, G, Preller, M.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The synthetic carbazole adhibin acts as selective myosin class-IX inhibitor in lung cancer cells
To Be Published
7B1A
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BU of 7b1a by Molmil
Myosin-II-AA mutant motor domain
Descriptor: 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-11-24
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
7B19
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BU of 7b19 by Molmil
Mutant Myosin-II-GGG motor domain
Descriptor: ADP METAVANADATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-11-24
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
3I5H
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BU of 3i5h by Molmil
The crystal structure of rigor like squid myosin S1 in the absence of nucleotide
Descriptor: CALCIUM ION, Myosin catalytic light chain LC-1, mantle muscle, ...
Authors:Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C.
Deposit date:2009-07-05
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure, 15, 2007
3I5F
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BU of 3i5f by Molmil
Crystal structure of squid MG.ADP myosin S1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin catalytic light chain LC-1, ...
Authors:Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C.
Deposit date:2009-07-05
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure, 15, 2007
3I5G
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BU of 3i5g by Molmil
Crystal structure of rigor-like squid myosin S1
Descriptor: CALCIUM ION, MALONATE ION, Myosin catalytic light chain LC-1, ...
Authors:Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C.
Deposit date:2009-07-05
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure, 15, 2007
3I5I
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BU of 3i5i by Molmil
The crystal structure of squid myosin S1 in the presence of SO4 2-
Descriptor: CALCIUM ION, Myosin catalytic light chain LC-1, mantle muscle, ...
Authors:Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C.
Deposit date:2009-07-05
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure, 15, 2007
3J04
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BU of 3j04 by Molmil
EM structure of the heavy meromyosin subfragment of Chick smooth muscle Myosin with regulatory light chain in phosphorylated state
Descriptor: Myosin light polypeptide 6, Myosin regulatory light chain 2, smooth muscle major isoform, ...
Authors:Baumann, B.A.J, Taylor, D, Huang, Z, Tama, F, Fagnant, P.M, Trybus, K, Taylor, K.
Deposit date:2011-02-18
Release date:2011-11-16
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation.
J.Mol.Biol., 415, 2012
1W7J
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BU of 1w7j by Molmil
Crystal Structure Of Myosin V Motor With Essential Light Chain + ADP-BeFx - Near Rigor
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Coureux, P.-D, Sweeney, H.L, Houdusse, A.
Deposit date:2004-09-03
Release date:2005-02-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three Myosin V Structures Delineate Essential Features of Chemo-Mechanical Transduction
Embo J., 23, 2004
1W9K
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BU of 1w9k by Molmil
Dictyostelium discoideum Myosin II motor domain S456E with bound MgADP-BeFx
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L.
Deposit date:2004-10-13
Release date:2006-03-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
3JAX
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BU of 3jax by Molmil
Heavy meromyosin from Schistosoma mansoni muscle thick filament by negative stain EM
Descriptor: myosin 2 heavy chain, myosin regulatory light chain, smooth muscle myosin essential light chain
Authors:Sulbaran, G, Alamo, L, Pinto, A, Marquez, G, Mendez, F, Padron, R, Craig, R.
Deposit date:2015-07-03
Release date:2015-10-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (23 Å)
Cite:An invertebrate smooth muscle with striated muscle myosin filaments.
Proc.Natl.Acad.Sci.USA, 112, 2015
1W9L
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BU of 1w9l by Molmil
Myosin II Dictyostelium discoideum motor domain S456E bound with MgADP-AlF4
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L.
Deposit date:2004-10-13
Release date:2006-03-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
1W9J
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BU of 1w9j by Molmil
Myosin II Dictyostelium discoideum motor domain S456Y bound with MgADP-AlF4
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L.
Deposit date:2004-10-13
Release date:2006-03-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
1W9I
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BU of 1w9i by Molmil
Myosin II Dictyostelium discoideum motor domain S456Y bound with MgADP-BeFx
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L.
Deposit date:2004-10-13
Release date:2006-03-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
1W7I
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BU of 1w7i by Molmil
Crystal Structure Of Myosin V Motor Without nucleotide soaked in 10 mM MgADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MYOSIN LIGHT CHAIN 1, SLOW-TWITCH MUSCLE A ISOFORM, ...
Authors:Coureux, P.-D, Sweeney, H.L, Houdusse, A.
Deposit date:2004-09-03
Release date:2005-02-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Three Myosin V Structures Delineate Essential Features of Chemo-Mechanical Transduction
Embo J., 23, 2004
1VOM
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BU of 1vom by Molmil
COMPLEX BETWEEN DICTYOSTELIUM MYOSIN AND MGADP AND VANADATE AT 1.9A RESOLUTION
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN, ...
Authors:Rayment, I, Smith, C.A.
Deposit date:1995-11-09
Release date:1996-12-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution.
Biochemistry, 35, 1996
3JBH
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BU of 3jbh by Molmil
TWO HEAVY MEROMYOSIN INTERACTING-HEADS MOTIFS FLEXIBLE DOCKED INTO TARANTULA THICK FILAMENT 3D-MAP ALLOWS IN DEPTH STUDY OF INTRA- AND INTERMOLECULAR INTERACTIONS
Descriptor: MYOSIN 2 ESSENTIAL LIGHT CHAIN STRIATED MUSCLE, MYOSIN 2 HEAVY CHAIN STRIATED MUSCLE, MYOSIN 2 REGULATORY LIGHT CHAIN STRIATED MUSCLE
Authors:Alamo, L, Qi, D, Wriggers, W, Pinto, A, Zhu, J, Bilbao, A, Gillilan, R.E, Hu, S, Padron, R.
Deposit date:2015-09-01
Release date:2016-03-09
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis.
J. Mol. Biol., 428, 2016
3L9I
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BU of 3l9i by Molmil
Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure
Descriptor: ACETATE ION, CALCIUM ION, Calmodulin, ...
Authors:Pylypenko, O, Song, L, Sweeney, L.H, Houdusse, A.
Deposit date:2010-01-05
Release date:2010-12-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Role of insert i of myosin VI in modulating nucleotide affinity
To be Published
4L79
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BU of 4l79 by Molmil
Crystal Structure of nucleotide-free Myosin 1b residues 1-728 with bound Calmodulin
Descriptor: Calmodulin, MAGNESIUM ION, Unconventional myosin-Ib
Authors:Shuman, H, Zwolak, A, Dominguez, R, Ostap, E.M.
Deposit date:2013-06-13
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning.
Proc.Natl.Acad.Sci.USA, 111, 2014
4ANJ
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BU of 4anj by Molmil
MYOSIN VI (MDinsert2-GFP fusion) PRE-POWERSTROKE STATE (MG.ADP.AlF4)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CALMODULIN, ...
Authors:Menetrey, J, Isabet, T, Ropars, V, Mukherjea, M, Pylypenko, O, Liu, X, Perez, J, Vachette, P, Sweeney, H.L, Houdusse, A.M.
Deposit date:2012-03-19
Release date:2012-10-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin Vi.
Mol.Cell, 48, 2012
4AE3
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BU of 4ae3 by Molmil
Crystal structure of ammosamide 272:myosin-2 motor domain complex
Descriptor: 1,2-ETHANEDIOL, ADP ORTHOVANADATE, AMMOSAMIDE 272, ...
Authors:Chinthalapudi, K, Heissler, S.M, Fenical, W, Manstein, D.J.
Deposit date:2012-01-05
Release date:2013-01-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Ammosamide Mediated Myosin Motor Activity Inhibition
To be Published

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