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1DTK	THE NMR SOLUTION STRUCTURE OF DENDROTOXIN K FROM THE VENOM OF DENDROASPIS POLYLEPIS POLYLEPIS Descriptor: DENDROTOXIN K Authors: Berndt, K, Guntert, P, Wuthrich, K. Deposit date: 1993-04-02 Release date: 1994-01-31 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Nuclear magnetic resonance solution structure of dendrotoxin K from the venom of Dendroaspis polylepis polylepis. J.Mol.Biol., 234, 1993
1DEM	PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS Descriptor: DENDROTOXIN I Authors: Lancelin, J.-M, Foray, M.-F. Deposit date: 1994-03-07 Release date: 1994-05-31 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Proteinase inhibitor homologues as potassium channel blockers. Nat.Struct.Biol., 1, 1994
1DEN	PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS Descriptor: DENDROTOXIN I Authors: Lancelin, J.-M, Foray, M.-F. Deposit date: 1994-03-07 Release date: 1994-05-31 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Proteinase inhibitor homologues as potassium channel blockers. Nat.Struct.Biol., 1, 1994
3BYB	Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom Descriptor: 2-ETHOXYETHANOL, SULFATE ION, Textilinin Authors: Millers, E.K, Guddat, L.W. Deposit date: 2008-01-15 Release date: 2009-01-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). Febs J., 276, 2009
1FAN	CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR Authors: Danishefsky, A.T, Wlodawer, A, Kim, K.-S, Tao, F, Woodward, C. Deposit date: 1992-08-21 Release date: 1993-10-31 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A. Protein Sci., 2, 1993
1G6X	ULTRA HIGH RESOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) MUTANT WITH ALTERED BINDING LOOP SEQUENCE Descriptor: 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION Authors: Addlagatta, A, Czapinska, H, Krzywda, S, Otlewski, J, Jaskolski, M. Deposit date: 2000-11-08 Release date: 2001-05-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (0.86 Å) Cite: Ultrahigh-resolution structure of a BPTI mutant. Acta Crystallogr.,Sect.D, 57, 2001
1SHP	THE NMR SOLUTION STRUCTURE OF A KUNITZ-TYPE PROTEINASE INHIBITOR FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS Descriptor: TRYPSIN INHIBITOR Authors: Antuch, W, Berndt, K, Chavez, M, Delfin, J, Wuthrich, K. Deposit date: 1992-11-17 Release date: 1994-01-31 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: The NMR solution structure of a Kunitz-type proteinase inhibitor from the sea anemone Stichodactyla helianthus. Eur.J.Biochem., 212, 1993
1UUB	Solution structure of a truncated bovine pancreatic trypsin inhibitor mutant, 3-58 BPTI (K15R, R17A, R42S) Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR Authors: Zhang, W, Nielsen, C.B, Hansen, P.E. Deposit date: 2003-12-17 Release date: 2004-01-29 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: NMR Solution Structures of Modified and Truncated Bovine Pancreatic Trypsin Inhibitor Proteins (3-58 Bpti'S) To be Published
1UUA	Solution structure of a truncated bovine pancreatic trypsin inhibitor, 3-58 BPTI. Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR Authors: Zhang, W, Nielsen, C.B, Hansen, P.E. Deposit date: 2003-12-17 Release date: 2004-01-29 Last modified: 2018-01-17 Method: SOLUTION NMR Cite: NMR Solution Structures of Modifies and Truncated Bovine Pancreatic Trypsin Inhibitor Proteins (3-58 Bpti'S) To be Published
1Y62	A 2.4 crystal structure of conkunitzin-S1, a novel Kunitz-fold cone snail neurotoxin. Descriptor: Conkunitzin-S1, SULFATE ION Authors: Dy, C.Y, Buczek, P, Horvath, M.P. Deposit date: 2004-12-03 Release date: 2005-07-12 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr.,Sect.D, 62, 2006
7V1N	Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI Descriptor: Isoform Beta of Tissue factor pathway inhibitor, Toxin B Authors: Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. Deposit date: 2021-08-05 Release date: 2022-02-23 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 185, 2022
6HAR	Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C Descriptor: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ... Authors: Shahar, A, Cohen, I, Radisky, E, Papo, N. Deposit date: 2018-08-08 Release date: 2019-02-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.497 Å) Cite: Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294, 2019
5C67	Human Mesotrypsin in complex with amyloid precursor protein inhibitor variant APPI-M17G/I18F/F34V Descriptor: Amyloid beta A4 protein, Trypsin-3 Authors: Kayode, O, Sankaran, B, Radisky, E.S. Deposit date: 2015-06-22 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy. Biochem.J., 473, 2016
8OTF	Ab typeII filament from Guam ALS/PDC Descriptor: Amyloid-beta precursor protein Authors: Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. Deposit date: 2023-04-20 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
6GFI	Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V Descriptor: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein Authors: Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. Deposit date: 2018-04-30 Release date: 2018-09-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries. Nat Commun, 9, 2018
5NX1	Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy Descriptor: Amyloid-beta A4 protein, Kallikrein-6 Authors: Shahar, A, Sananes, A, Radisky, E.S, Papo, N. Deposit date: 2017-05-09 Release date: 2018-05-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.853 Å) Cite: A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
5NX3	Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy Descriptor: Amyloid-beta A4 protein, Kallikrein-6 Authors: Shahar, A, Sananes, A, Radisky, E.S, Papo, N. Deposit date: 2017-05-09 Release date: 2018-05-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.296 Å) Cite: A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
4TPI	THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... Authors: Bode, W, Walter, J. Deposit date: 1985-06-11 Release date: 1985-11-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor Eur.J.Biochem., 144, 1984
4U32	Human mesotrypsin complexed with HAI-2 Kunitz domain 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... Authors: Wang, R, Soares, A.S, Radisky, E.S. Deposit date: 2014-07-18 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN. J.Biol.Chem., 289, 2014
4U30	Human mesotrypsin complexed with bikunin Kunitz domain 2 Descriptor: CALCIUM ION, Trypsin-3, Trypstatin Authors: Wang, R, Soares, A.S, Radisky, E.S. Deposit date: 2014-07-18 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN. J.Biol.Chem., 289, 2014
4ISO	Crystal Structure of Matriptase in complex with its inhibitor HAI-1 Descriptor: DI(HYDROXYETHYL)ETHER, GLUTATHIONE, GLYCEROL, ... Authors: Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. Deposit date: 2013-01-16 Release date: 2013-03-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288, 2013
4ISN	Crystal Structure of Matriptase in complex with its inhibitor HAI-1 Descriptor: GLUTATHIONE, Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, ... Authors: Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. Deposit date: 2013-01-16 Release date: 2013-03-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288, 2013
4ISL	Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 Descriptor: GLUTATHIONE, GLYCEROL, Kunitz-type protease inhibitor 1, ... Authors: Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. Deposit date: 2013-01-16 Release date: 2013-03-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288, 2013
3GYM	Structure of Prostasin in Complex with Aprotinin Descriptor: Pancreatic trypsin inhibitor, Prostasin Authors: Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. Deposit date: 2009-04-03 Release date: 2009-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
4NTW	Structure of acid-sensing ion channel in complex with snake toxin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... Authors: Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. Deposit date: 2013-12-02 Release date: 2014-02-19 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.07 Å) Cite: X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel. Cell(Cambridge,Mass.), 156, 2014

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