5YWY
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP4 IN COMPLEX WITH FAB AND ONO-AE3-208
Descriptor:Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5ZHP
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M3 MUSCARINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH A SELECTIVE ANTAGONIST
Descriptor:Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, TETRAETHYLENE GLYCOL, MALTOSE, ...
Authors:Liu, H., Hofmann, J., Fish, I., Schaake, B., Eitel, K., Bartuschat, A., Kaindl, J., Rampp, H., Banerjee, A., Hubner, H., Clark, M.J., Vincent, S.G., Fisher, J., Heinrich, M., Hirata, K., Liu, X., Sunahara, R.K., Shoichet, B.K., Kobilka, B.K., Gmeiner, P.
Deposit date:2018-03-13
Release date:2018-11-28
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5ZK3
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH QNB
Descriptor:Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZK8
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CRYSTAL STRUCTURE OF M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH NMS
Descriptor:Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKB
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH AF-DX 384
Descriptor:Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKC
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH NMS
Descriptor:Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKQ
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CRYSTAL STRUCTURE OF THE HUMAN PLATELET-ACTIVATING FACTOR RECEPTOR IN COMPLEX WITH ABT-491
Descriptor:Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Cao, C., Zhao, Q., Zhang, X.C., Wu, B.
Deposit date:2018-03-25
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
6AK3
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP3 BOUND TO PROSTAGLANDIN E2
Descriptor:Prostaglandin E2 receptor EP3 subtype,Soluble cytochrome b562, (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
Authors:Morimoto, K., Suno, R., Iwata, S., Kobayashi, T.
Deposit date:2018-08-29
Release date:2018-12-05
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.
Nat. Chem. Biol., 15, 2019
6D26
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CRYSTAL STRUCTURE OF THE PROSTAGLANDIN D2 RECEPTOR CRTH2 WITH FEVIPIPRANT
Descriptor:Prostaglandin D2 receptor 2, Endolysin chimera, fevipiprant, ...
Authors:Wang, L., Yao, D., Deepak, K., Liu, H., Gong, W., Fan, H., Wei, Z., Zhang, C.
Deposit date:2018-04-13
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Structures of the prostaglandin D2 receptor CRTH2 with antagonists
To be Published
6D27
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CRYSTAL STRUCTURE OF THE PROSTAGLANDIN D2 RECEPTOR CRTH2 WITH CAY10471
Descriptor:Prostaglandin D2 receptor 2, Endolysin chimera, SULFATE ION, ...
Authors:Wang, L., Yao, D., Deepak, K., Liu, H., Gong, W., Fan, H., Wei, Z., Zhang, C.
Deposit date:2018-04-13
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.738 Å)
Cite:Structures of the prostaglandin D2 receptor CRTH2 with antagonists
To be Published
6DO1
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STRUCTURE OF NANOBODY-STABILIZED ANGIOTENSIN II TYPE 1 RECEPTOR BOUND TO S1I8
Descriptor:Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein, Nanobody Nb.AT110i1, Angiotensin-like peptide S1I8, ...
Authors:Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C.
Deposit date:2018-06-08
Release date:2019-01-30
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.
Cell, 176, 2019
6DRX
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRY
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRZ
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, CHOLESTEROL, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
1F88
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CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
Descriptor:RHODOPSIN, N-ACETYL-D-GLUCOSAMINE, MERCURY (II) ION, ...
Authors:Okada, T., Palczewski, K., Stenkamp, R.E., Miyano, M.
Deposit date:2000-06-29
Release date:2000-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of rhodopsin: A G protein-coupled receptor.
Science, 289, 2000
1GZM
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STRUCTURE OF BOVINE RHODOPSIN IN A TRIGONAL CRYSTAL FORM
Descriptor:RHODOPSIN, RETINAL, PALMITIC ACID, ...
Authors:Li, J.
Deposit date:2002-05-24
Release date:2003-11-20
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Bovine Rhodopsin in a Trigonal Crystal Form
J.Mol.Biol., 343, 2004
1HZX
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CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
Descriptor:RHODOPSIN, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Teller, D.C., Okada, T., Behnke, C.A., Palczewski, K., Stenkamp, R.E.
Deposit date:2001-01-26
Release date:2001-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).
Biochemistry, 40, 2001
1JFP
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STRUCTURE OF BOVINE RHODOPSIN (DARK ADAPTED)
Descriptor:rhodopsin, RETINAL
Authors:Yeagle, P.L., Choi, G., Albert, A.D.
Deposit date:2001-06-21
Release date:2001-10-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms.
Biochemistry, 40, 2001
1L9H
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CRYSTAL STRUCTURE OF BOVINE RHODOPSIN AT 2.6 ANGSTROMS RESOLUTION
Descriptor:rhodopsin, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Okada, T., Fujiyoshi, Y., Silow, M., Navarro, J., Landau, E.M., Shichida, Y.
Deposit date:2002-03-23
Release date:2002-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 99, 2002
1LN6
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STRUCTURE OF BOVINE RHODOPSIN (METARHODOPSIN II)
Descriptor:RHODOPSIN, RETINAL
Authors:Choi, G., Landin, J., Galan, J.F., Birge, R.R., Albert, A.D., Yeagle, P.L.
Deposit date:2002-05-03
Release date:2002-07-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin.
Biochemistry, 41, 2002
1U19
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CRYSTAL STRUCTURE OF BOVINE RHODOPSIN AT 2.2 ANGSTROMS RESOLUTION
Descriptor:Rhodopsin, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Okada, T., Sugihara, M., Bondar, A.N., Elstner, M., Entel, P., Buss, V.
Deposit date:2004-07-15
Release date:2004-10-12
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
J.Mol.Biol., 342, 2004
2G87
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CRYSTALLOGRAPHIC MODEL OF BATHORHODOPSIN
Descriptor:Rhodopsin, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Nakamichi, H., Okada, T.
Deposit date:2006-03-02
Release date:2006-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic analysis of primary visual photochemistry
Angew.Chem.Int.Ed.Engl., 45, 2006
2HPY
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CRYSTALLOGRAPHIC MODEL OF LUMIRHODOPSIN
Descriptor:Rhodopsin, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Nakamichi, H., Okada, T.
Deposit date:2006-07-18
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Local peptide movement in the photoreaction intermediate of rhodopsin
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I35
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CRYSTAL STRUCTURE OF RHOMBOHEDRAL CRYSTAL FORM OF GROUND-STATE RHODOPSIN
Descriptor:Rhodopsin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Stenkamp, R.E., Le Trong, I., Lodowski, D.T., Salom, D., Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I36
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CRYSTAL STRUCTURE OF TRIGONAL CRYSTAL FORM OF GROUND-STATE RHODOPSIN
Descriptor:Rhodopsin, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Stenkamp, R.E., Le Trong, I., Lodowski, D.T., Salom, D., Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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