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4ZIQ
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BU of 4ziq by Molmil
Crystal structure of trypsin activated alpha-2-macroglobulin from Escherichia coli.
Descriptor: CHLORIDE ION, GLYCEROL, Uncharacterized lipoprotein YfhM
Authors:Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4U48
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BU of 4u48 by Molmil
Crystal structure of Salmonella alpha-2-macroglobulin
Descriptor: Putative inner membrane lipoprotein
Authors:Wong, S.G, Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4U4J
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BU of 4u4j by Molmil
Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G
Descriptor: Putative inner membrane lipoprotein
Authors:Wong, S.G, Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4ZH1
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BU of 4zh1 by Molmil
Complement factor H in complex with the GM1 glycan
Descriptor: Complement C3, Complement factor H, GLYCEROL, ...
Authors:Blaum, B.S, Stehle, T.
Deposit date:2015-04-24
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
Glycobiology, 26, 2016
4U59
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BU of 4u59 by Molmil
Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine
Descriptor: alpha-2-macroglobulin
Authors:Wong, S.G, Dessen, A.
Deposit date:2014-07-24
Release date:2014-09-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4ZIU
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BU of 4ziu by Molmil
Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning the residues from domain MG7 to the C-terminus.
Descriptor: GLYCEROL, NICKEL (II) ION, Uncharacterized lipoprotein YfhM
Authors:Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
3OED
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BU of 3oed by Molmil
The structure of the complex between complement receptor CR2 and its ligand complement fragment C3d
Descriptor: Complement C3, Complement receptor type 2
Authors:Isenman, D.E, van den Elsen, J.M.H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:A crystal structure of the complex between human complement receptor 2 and its ligand C3d.
Science, 332, 2011
5A42
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BU of 5a42 by Molmil
Cryo-EM single particle 3D reconstruction of the native conformation of E. coli alpha-2-macroglobulin (ECAM)
Descriptor: UNCHARACTERIZED LIPOPROTEIN YFHM
Authors:Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, F.X.
Deposit date:2015-06-04
Release date:2015-07-29
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Structural and Functional Insights Into Escherichia Coli Alpha2- Macroglobulin Endopeptidase Snap-Trap Inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
3OXU
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BU of 3oxu by Molmil
Complement components factor H CCP19-20 and C3d in complex
Descriptor: Complement C3, GLYCEROL, HF protein
Authors:Morgan, H.P, Schmidt, C.Q, Guariento, M, Gillespie, D, Herbert, A.P, Mertens, H, Blaum, B.S, Svergun, D, Johansson, C.M, Uhrin, D, Barlow, P.N, Hannan, J.P.
Deposit date:2010-09-22
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for engagement by complement factor H of C3b on a self surface.
Nat.Struct.Mol.Biol., 18, 2011
3PRX
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BU of 3prx by Molmil
Structure of Complement C5 in Complex with CVF and SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ...
Authors:Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
3PVM
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BU of 3pvm by Molmil
Structure of Complement C5 in Complex with CVF
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5
Authors:Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R.
Deposit date:2010-12-07
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
3KLS
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BU of 3kls by Molmil
Structure of complement C5 in complex with SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-09
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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BU of 3km9 by Molmil
Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3L5N
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BU of 3l5n by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor, ...
Authors:Geisbrecht, B.V, Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
7S63
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BU of 7s63 by Molmil
Native-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha 2-Macroglobulin
Authors:Arimura, Y, Funabiki, H.
Deposit date:2021-09-13
Release date:2022-01-05
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:Structural Mechanics of the Alpha-2-Macroglobulin Transformation.
J.Mol.Biol., 434, 2021
7S62
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BU of 7s62 by Molmil
Locally refined protomer structure of native-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha 2-macroglobulin
Authors:Arimura, Y, Funabiki, H.
Deposit date:2021-09-12
Release date:2022-01-05
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Structural Mechanics of the Alpha-2-Macroglobulin Transformation.
J.Mol.Biol., 434, 2021
7S64
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BU of 7s64 by Molmil
Intermediate-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer
Descriptor: Alpha 2-macroglobulin
Authors:Arimura, Y, Funabiki, H.
Deposit date:2021-09-13
Release date:2022-01-05
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (6.43 Å)
Cite:Structural Mechanics of the Alpha-2-Macroglobulin Transformation.
J.Mol.Biol., 434, 2021
7TV9
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BU of 7tv9 by Molmil
HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, APL-1030 Nanofitin, Complement C3 beta chain, ...
Authors:Fontano, E, Nadupalli, A, Lakshminarasimhan, D, White, A, Garlish, J, Cinier, M, Chevrel, A, Perrocheau, A, Eyerman, D, Orme, M, Kitten, O, Scheibler, L.
Deposit date:2022-02-04
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation.
Biomolecules, 12, 2022
5FOB
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BU of 5fob by Molmil
Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COMPLEMENT C3 BETA CHAIN, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO9
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BU of 5fo9 by Molmil
Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO8
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BU of 5fo8 by Molmil
Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO7
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BU of 5fo7 by Molmil
Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
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BU of 5foa by Molmil
Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)
Descriptor: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
6RU5
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BU of 6ru5 by Molmil
human complement C3 in complex with the hC3Nb1 nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jensen, R.K, Andersen, G.R.
Deposit date:2019-05-27
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front Immunol, 10, 2019
6RUR
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BU of 6rur by Molmil
Structure of the SCIN stabilized C3bBb convertase bound to properdin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, ...
Authors:Pedersen, D.V, Gadeberg, T.A.F, Andersen, G.R.
Deposit date:2019-05-29
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front Immunol, 10, 2019

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