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6BZO
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BU of 6bzo by Molmil
Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA
Descriptor: DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
Deposit date:2017-12-25
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C06
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BU of 6c06 by Molmil
Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
1ZYR
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BU of 1zyr by Molmil
Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ...
Authors:Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2A6E
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BU of 2a6e by Molmil
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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BU of 2a6h by Molmil
Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2A69
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BU of 2a69 by Molmil
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A68
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BU of 2a68 by Molmil
Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-01
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2BE5
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BU of 2be5 by Molmil
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-10-22
Release date:2005-11-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
2CW0
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BU of 2cw0 by Molmil
Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
4G7H
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BU of 4g7h by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex
Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7O
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BU of 4g7o by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA
Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7Z
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BU of 4g7z by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at template-strand position +1
Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*(BRU)P*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.815 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4JKR
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BU of 4jkr by Molmil
Crystal Structure of E. coli RNA Polymerase in complex with ppGpp
Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Zuo, Y, Wang, Y, Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4JK1
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BU of 4jk1 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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BU of 4jk2 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4KI2
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BU of 4ki2 by Molmil
Crystallographic analysis of an RNA-polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA
Descriptor: DNA (5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3'), POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2013-05-01
Release date:2013-09-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes.
Acta Crystallogr.,Sect.F, 69, 2013
4KMU
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BU of 4kmu by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
8GZG
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BU of 8gzg by Molmil
Cryo-EM structure of Synechocystis sp. PCC 6803 RPitc
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Shen, L.Q, You, L.L, Zhang, Y.
Deposit date:2022-09-27
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc
Proc.Natl.Acad.Sci.USA, 2023
8GZH
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BU of 8gzh by Molmil
Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:You, L.L, Shen, L.Q, Zhang, Y.
Deposit date:2022-09-27
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc
Proc.Natl.Acad.Sci.USA, 2023
8HIH
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BU of 8hih by Molmil
Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Shi, J, Xu, J.C.
Deposit date:2022-11-20
Release date:2023-06-07
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
8H3V
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BU of 8h3v by Molmil
Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC
Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z.
Deposit date:2022-10-09
Release date:2023-10-04
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:DNA looping mediates cooperative transcription activation.
Nat.Struct.Mol.Biol., 31, 2024
8H40
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BU of 8h40 by Molmil
Cryo-EM structure of the transcription activation complex NtcA-TAC
Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z.
Deposit date:2022-10-09
Release date:2023-10-04
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:DNA looping mediates cooperative transcription activation.
Nat.Struct.Mol.Biol., 31, 2024
8HVR
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BU of 8hvr by Molmil
Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter
Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Wang, Y, Zheng, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structural basis of transcription activation by Streptomyces antibiotic regulatory protein family regulator AfsR
To Be Published
8IGR
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BU of 8igr by Molmil
Cryo-EM structure of CII-dependent transcription activation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y.
Deposit date:2023-02-21
Release date:2023-05-17
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of lambda CII-dependent transcription activation.
Structure, 31, 2023
8IGS
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BU of 8igs by Molmil
Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y.
Deposit date:2023-02-21
Release date:2023-05-17
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of lambda CII-dependent transcription activation.
Structure, 31, 2023

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PDB entries from 2024-03-27

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