2QGQ
| Crystal structure of TM_1862 from Thermotoga maritima. Northeast Structural Genomics Consortium target VR77 | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Protein TM_1862 | Authors: | Forouhar, F, Neely, H, Hussain, M, Seetharaman, J, Fang, Y, Chen, C.X, Cunningham, K, Conover, K, Ma, L.-C, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-29 | Release date: | 2007-07-17 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Post-translational Modification of Ribosomal Proteins: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF RimO FROM THERMOTOGA MARITIMA, A RADICAL S-ADENOSYLMETHIONINE METHYLTHIOTRANSFERASE. J.Biol.Chem., 285, 2010
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4M7S
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4M7T
| Crystal structure of BtrN in complex with AdoMet and 2-DOIA | Descriptor: | (1R,2S,3S,4R,5S)-5-aminocyclohexane-1,2,3,4-tetrol, BtrN, GLYCEROL, ... | Authors: | Drennan, C.L, Goldman, P.J. | Deposit date: | 2013-08-12 | Release date: | 2013-10-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proc.Natl.Acad.Sci.USA, 110, 2013
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7PD1
| Crystal structure of the L-tyrosine-bound radical SAM tyrosine lyase ThiH (2-iminoacetate synthase) from Thermosinus carboxydivorans | Descriptor: | 5'-DEOXYADENOSINE, BROMIDE ION, GLYCEROL, ... | Authors: | Amara, P, Saragaglia, C, Mouesca, J.-M, Martin, L, Nicolet, Y. | Deposit date: | 2021-08-04 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases. Nat Commun, 13, 2022
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7PD2
| Crystal structure of the substrate-free radical SAM tyrosine lyase ThiH (2-iminoacetate synthase) from Thermosinus carboxydivorans | Descriptor: | 5'-DEOXYADENOSINE, GLYCEROL, IRON/SULFUR CLUSTER, ... | Authors: | Amara, P, Saragaglia, C, Mouesca, J.-M, Martin, L, Nicolet, Y. | Deposit date: | 2021-08-04 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases. Nat Commun, 13, 2022
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2YX0
| Crystal structure of P. horikoshii TYW1 | Descriptor: | radical sam enzyme | Authors: | Goto-Ito, S, Ishii, R, Ito, T, Shibata, R, Fusatomi, E, Sekine, S, Bessho, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-23 | Release date: | 2007-10-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis Acta Crystallogr.,Sect.D, 63, 2007
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6Q2P
| Crystal structure of mouse viperin bound to cytidine triphosphate and S-adenosylhomocysteine | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, ... | Authors: | Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E. | Deposit date: | 2019-08-08 | Release date: | 2020-01-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.452 Å) | Cite: | Structural Basis of the Substrate Selectivity of Viperin. Biochemistry, 59, 2020
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6Q2Q
| Crystal structure of mouse viperin bound to uridine triphosphate and S-adenosylhomocysteine | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, IRON/SULFUR CLUSTER, ... | Authors: | Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E. | Deposit date: | 2019-08-08 | Release date: | 2020-01-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Structural Basis of the Substrate Selectivity of Viperin. Biochemistry, 59, 2020
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2Z2U
| Crystal structure of archaeal TYW1 | Descriptor: | UPF0026 protein MJ0257 | Authors: | Suzuki, Y, Ishitani, R, Nureki, O. | Deposit date: | 2007-05-28 | Release date: | 2007-10-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Radical SAM Enzyme Catalyzing Tricyclic Modified Base Formation in tRNA J.Mol.Biol., 372, 2007
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3RFA
| X-ray structure of RlmN from Escherichia coli in complex with S-adenosylmethionine | Descriptor: | IRON/SULFUR CLUSTER, Ribosomal RNA large subunit methyltransferase N, S-ADENOSYLMETHIONINE | Authors: | Boal, A.K, Grove, T.L, McLaughlin, M.I, Yennawar, N, Booker, S.J, Rosenzweig, A.C. | Deposit date: | 2011-04-05 | Release date: | 2011-05-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for methyl transfer by a radical SAM enzyme. Science, 332, 2011
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3RF9
| X-ray structure of RlmN from Escherichia coli | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, IRON/SULFUR CLUSTER, Ribosomal RNA large subunit methyltransferase N | Authors: | Boal, A.K, Grove, T.L, McLaughlin, M.I, Yennawar, N, Booker, S.J, Rosenzweig, A.C. | Deposit date: | 2011-04-05 | Release date: | 2011-05-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for methyl transfer by a radical SAM enzyme. Science, 332, 2011
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6XIG
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6XI9
| X-ray crystal structure of MqnE from Pedobacter heparinus in complex with aminofutalosine and methionine | Descriptor: | 9-[7-(3-carboxyphenyl)-5,6-dideoxy-beta-D-ribo-heptodialdo-1,4-furanosyl]-9H-purin-6-amine, Aminodeoxyfutalosine synthase, CHLORIDE ION, ... | Authors: | Grove, T.L, Bonanno, J.B, Almo, S.C. | Deposit date: | 2020-06-19 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. Biochemistry, 59, 2020
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2A5H
| 2.1 Angstrom X-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale SB4, with Michaelis analog (L-alpha-lysine external aldimine form of pyridoxal-5'-phosphate). | Descriptor: | IRON/SULFUR CLUSTER, L-lysine 2,3-aminomutase, LYSINE, ... | Authors: | Lepore, B.W, Ruzicka, F.J, Frey, P.A, Ringe, D. | Deposit date: | 2005-06-30 | Release date: | 2005-10-04 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The X-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proc.Natl.Acad.Sci.Usa, 102, 2005
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6EFN
| Structure of a RiPP maturase, SkfB | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | Authors: | Grell, T.A.J, Drennan, C.L. | Deposit date: | 2018-08-16 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.291 Å) | Cite: | Structure of a RiPP maturase, SkfB J.Biol.Chem., 2018
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1OLT
| Coproporphyrinogen III oxidase (HemN) from Escherichia coli is a Radical SAM enzyme. | Descriptor: | IRON/SULFUR CLUSTER, OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE, S-ADENOSYLMETHIONINE | Authors: | Layer, G, Moser, J, Heinz, D.W, Jahn, D, Schubert, W.-D. | Deposit date: | 2003-08-13 | Release date: | 2003-12-04 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal Structure of Coproporphyrinogen III Oxidase Reveals Cofactor Geometry of Radical Sam Enzymes Embo J., 22, 2003
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4RTB
| X-ray structure of the FeFe-hydrogenase maturase HydG from Carboxydothermus hydrogenoformans | Descriptor: | CHLORIDE ION, HydG protein, IRON/SULFUR CLUSTER, ... | Authors: | Nicolet, Y, Pagnier, A, Zeppieri, L, Martin, L, Amara, P, Fontecilla-Camps, J.C. | Deposit date: | 2014-11-14 | Release date: | 2015-01-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Crystal Structure of HydG from Carboxydothermus hydrogenoformans: A Trifunctional [FeFe]-Hydrogenase Maturase. Chembiochem, 16, 2015
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8FOL
| The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to SAM, alternate crystal form | Descriptor: | CHLORIDE ION, IRON/SULFUR CLUSTER, POTASSIUM ION, ... | Authors: | Moody, J.D, Saxton, A.J, Galambas, A, Lawrence, C.M, Broderick, J.B. | Deposit date: | 2022-12-31 | Release date: | 2023-05-24 | Last modified: | 2023-06-21 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage. J.Biol.Chem., 299, 2023
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8FO0
| The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to a partially cleaved SAM molecule | Descriptor: | IRON/SULFUR CLUSTER, POTASSIUM ION, Pyruvate formate-lyase 1-activating enzyme, ... | Authors: | Moody, J.D, Saxton, A.J, Galambas, A, Lawrence, C.M, Broderick, J.B. | Deposit date: | 2022-12-29 | Release date: | 2023-05-24 | Last modified: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage. J.Biol.Chem., 299, 2023
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8FSI
| The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to SAM | Descriptor: | CHLORIDE ION, IRON/SULFUR CLUSTER, POTASSIUM ION, ... | Authors: | Moody, J.D, Galambas, A, Lawrence, C.M, Broderick, J.B. | Deposit date: | 2023-01-10 | Release date: | 2023-05-24 | Last modified: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage. J.Biol.Chem., 299, 2023
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6B4C
| Structure of Viperin from Trichoderma virens | Descriptor: | CITRATE ANION, SULFATE ION, Viperin | Authors: | Huang, R.H, Selvadurai, K. | Deposit date: | 2017-09-26 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.795 Å) | Cite: | Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin. J.Biol.Chem., 293, 2018
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6FZ6
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6C8V
| X-ray structure of PqqE from Methylobacterium extorquens | Descriptor: | Coenzyme PQQ synthesis protein E, FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER | Authors: | Gizzi, A.S, Grove, T.L, Bonanno, J.B, Almo, S.C. | Deposit date: | 2018-01-25 | Release date: | 2018-02-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE. Biochemistry, 57, 2018
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1R30
| The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Biotin synthase, ... | Authors: | Berkovitch, F, Nicolet, Y, Wan, J.T, Jarrett, J.T, Drennan, C.L. | Deposit date: | 2003-09-30 | Release date: | 2004-01-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science, 303, 2004
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6DJT
| Structure of TYW1 with a lysine-pyruvate adduct bound | Descriptor: | DI(HYDROXYETHYL)ETHER, FE2/S3 CLUSTER, GLYCEROL, ... | Authors: | Grell, T.A.J, Drennan, C.L. | Deposit date: | 2018-05-26 | Release date: | 2018-06-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1. J. Am. Chem. Soc., 140, 2018
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