PDB: 153 resultsInfo pagesStatus searchChemie searchBIRD

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7CYL	Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L) Descriptor: RNA-binding protein FUS, Transportin-1 Authors: Yoshizawa, T, Chook, Y.M. Deposit date: 2020-09-03 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Sci Rep, 11, 2021
2Q5D	Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form Descriptor: Importin beta-1 subunit, Snurportin-1 Authors: Mitrousis, G, Cingolani, G. Deposit date: 2007-05-31 Release date: 2008-01-22 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}. J.Biol.Chem., 283, 2008
7DBG	Yeast CRM1e (apo) in complex with Ran-RanBP1 Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-10-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
2QMR	Karyopherin beta2/transportin Descriptor: Transportin-1 Authors: Cansizoglu, A.E, Chook, Y.M. Deposit date: 2007-07-16 Release date: 2007-10-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Conformational heterogeneity of karyopherin beta2 is segmental Structure, 15, 2007
4FDD	Crystal structure of KAP beta2-PY-NLS Descriptor: RNA-binding protein FUS, Transportin-1 Authors: Zhang, Z.C, Chook, Y.M. Deposit date: 2012-05-28 Release date: 2012-07-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc.Natl.Acad.Sci.USA, 109, 2012
4FQ3	Crystal structure of transportin/FUS-NLS Descriptor: Fusion (Involved in t(12;16) in malignant liposarcoma), Transportin-1 Authors: Gong, W, Niu, C, Jia, M, Gao, F. Deposit date: 2012-06-25 Release date: 2013-08-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of transportin/FUS-NLS To be Published
3ND2	Structure of Yeast Importin-beta (Kap95p) Descriptor: Importin subunit beta-1 Authors: Forwood, J.K, Kobe, B. Deposit date: 2010-06-06 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures Structure, 18, 2010
3NC0	Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II) Descriptor: DI(HYDROXYETHYL)ETHER, Exportin-1, GLYCEROL, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3NBY	Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.42 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3NBZ	Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I) Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3NC1	Crystal structure of the CRM1-RanGTP complex Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.35 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
6KFT	MVM NS2 mutant Nm42 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... Authors: Sun, Q, Li, Y. Deposit date: 2019-07-08 Release date: 2020-07-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6M6X	Oridonin in complex with CRM1#-Ran-RanBP1 Descriptor: (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-03-16 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
6LQ9	S109 in complex with CRM1-Ran-RanBP1 Descriptor: (3~{R},4~{S})-1-[[6-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3,4-dimethyl-pyrrolidine-2,5-dione, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-01-13 Release date: 2021-06-23 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J.Med.Chem., 64, 2021
6M60	Plumbagin in complex with CRM1#-Ran-RanBP1 Descriptor: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-03-12 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIS	Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Monecke, T, Port, S.A, Dickmanns, A, Kehlenbach, R.H, Ficner, R. Deposit date: 2015-09-01 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep, 13, 2015
6N88	Cryo-EM structure of the Importin7:Importin beta:Histone H1.0 complex Descriptor: Histone H1.0, Importin subunit beta-1, MGC52556 protein Authors: Bilokapic, S, Ivic, N, Halic, M. Deposit date: 2018-11-28 Release date: 2019-02-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Fuzzy Interactions Form and Shape the Histone Transport Complex. Mol. Cell, 73, 2019
5DH9	Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
8DYO	Cryo-EM structure of Importin-4 bound to RanGTP Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... Authors: Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. Deposit date: 2022-08-04 Release date: 2022-09-21 Last modified: 2022-10-05 Method: ELECTRON MICROSCOPY (7.1 Å) Cite: Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
8F7A	Cryo-EM structure of Importin-9 bound to RanGTP Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ... Authors: Bernardes, N.E, Chook, Y.M. Deposit date: 2022-11-18 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.78 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8F0X	Cryo-EM structure of Kap114 bound to H2A-H2B Descriptor: Histone H2A.2, Histone H2B.2, Importin subunit beta-5 Authors: Jiou, J, Chook, Y.M. Deposit date: 2022-11-04 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E	Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ... Authors: Jiou, J, Chook, Y.M. Deposit date: 2022-11-04 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8F19	Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ... Authors: Jiou, J, Chook, Y.M. Deposit date: 2022-11-04 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8GCN	CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER Descriptor: Importin subunit alpha-1, Importin subunit beta-1 Authors: Ko, Y, Cingolani, G. Deposit date: 2023-03-02 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.95 Å) Cite: CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER To Be Published

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