3ETG
| Glutamate dehydrogenase complexed with GW5074 | Descriptor: | (3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,3-dihydro-2H-indol-2-one, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Li, M, Smith, T.J. | Deposit date: | 2008-10-07 | Release date: | 2009-06-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Novel Inhibitors Complexed with Glutamate Dehydrogenase: ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICS J.Biol.Chem., 284, 2009
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3ETD
| Structure of glutamate dehydrogenase complexed with bithionol | Descriptor: | 2,2'-sulfanediylbis(4,6-dichlorophenol), GLUD1 protein, GLUTAMIC ACID, ... | Authors: | Li, M, Smith, T.J. | Deposit date: | 2008-10-07 | Release date: | 2009-06-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Novel Inhibitors Complexed with Glutamate Dehydrogenase: ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICS J.Biol.Chem., 284, 2009
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1GTM
| STRUCTURE OF GLUTAMATE DEHYDROGENASE | Descriptor: | GLUTAMATE DEHYDROGENASE, SULFATE ION | Authors: | Yip, K.S.P, Stillman, T.J, Britton, K.L, Pasquo, A, Rice, D.W. | Deposit date: | 1996-08-22 | Release date: | 1997-01-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. Structure, 3, 1995
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1HWY
| BOVINE GLUTAMATE DEHYDROGENASE COMPLEXED WITH NAD AND 2-OXOGLUTARATE | Descriptor: | 2-OXOGLUTARIC ACID, GLUTAMATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Smith, T.J, Peterson, P.E, Schmidt, T, Fang, J, Stanley, C.A. | Deposit date: | 2001-01-10 | Release date: | 2001-01-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation. J.Mol.Biol., 307, 2001
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1HRD
| GLUTAMATE DEHYDROGENASE | Descriptor: | GLUTAMATE DEHYDROGENASE | Authors: | Britton, K.L, Baker, P.J, Stillman, T.J, Rice, D.W. | Deposit date: | 1996-04-03 | Release date: | 1997-03-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. Structure, 3, 1995
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1K89
| K89L MUTANT OF GLUTAMATE DEHYDROGENASE | Descriptor: | GLUTAMATE DEHYDROGENASE | Authors: | Stillman, T.J, Migueis, A.M.B, Wang, X.G, Baker, P.J, Britton, K.L, Engel, P.C, Rice, D.W. | Deposit date: | 1998-06-05 | Release date: | 1999-01-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Insights into the mechanism of domain closure and substrate specificity of glutamate dehydrogenase from Clostridium symbiosum. J.Mol.Biol., 285, 1999
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1L1F
| Structure of human glutamate dehydrogenase-apo form | Descriptor: | Glutamate Dehydrogenase 1 | Authors: | Smith, T.J, Schmidt, T, Fang, J, Wu, J, Siuzdak, G, Stanley, C.A. | Deposit date: | 2002-02-15 | Release date: | 2002-03-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of apo human glutamate dehydrogenase details subunit communication and allostery. J.Mol.Biol., 318, 2002
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1LEH
| LEUCINE DEHYDROGENASE FROM BACILLUS SPHAERICUS | Descriptor: | LEUCINE DEHYDROGENASE | Authors: | Baker, P.J, Turnbull, A.P, Sedelnikova, S.E, Stillman, T.J, Rice, D.W. | Deposit date: | 1995-06-09 | Release date: | 1996-12-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A role for quaternary structure in the substrate specificity of leucine dehydrogenase. Structure, 3, 1995
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8EW0
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8GXD
| L-LEUCINE DEHYDROGENASE FROM EXIGUOBACTERIUM SIBIRICUM | Descriptor: | CALCIUM ION, GLYCEROL, Glu/Leu/Phe/Val dehydrogenase | Authors: | Mu, X, Nie, Y, Wu, T, Wang, Y, Zhang, N, Yin, D, Xu, Y. | Deposit date: | 2022-09-19 | Release date: | 2023-04-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Reshaping Substrate-Binding Pocket of Leucine Dehydrogenase for Bidirectionally Accessing Structurally Diverse Substrates Acs Catalysis, 13, 2023
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8HIQ
| cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | Descriptor: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | Deposit date: | 2022-11-21 | Release date: | 2023-02-08 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
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8HJ9
| cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | Descriptor: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | Deposit date: | 2022-11-22 | Release date: | 2023-02-08 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
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8HIZ
| cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | Descriptor: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | Deposit date: | 2022-11-22 | Release date: | 2023-02-08 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
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8HHO
| cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | Descriptor: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | Deposit date: | 2022-11-16 | Release date: | 2023-02-08 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
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8HJ3
| cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | Descriptor: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | Deposit date: | 2022-11-22 | Release date: | 2023-02-08 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
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6DHL
| Bovine glutamate dehydrogenase complexed with epicatechin-3-gallate (ECG) | Descriptor: | (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, Glutamate dehydrogenase 1, mitochondrial | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Method: | X-RAY DIFFRACTION (3.624 Å) | Cite: | Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site. J. Biol. Chem., 286, 2011
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6DHD
| Bovine glutamate dehydrogenase complexed with NADH, GTP, glutamate | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Smith, T.J. | Deposit date: | 2018-05-19 | Release date: | 2018-07-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation. J. Mol. Biol., 307, 2001
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6DHM
| Bovine glutamate dehydrogenase complexed with zinc | Descriptor: | GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, ... | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
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6DHQ
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6DHK
| Bovine glutamate dehydrogenase complexed with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Glutamate dehydrogenase 1, mitochondrial | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation. Biochemistry, 42, 2003
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6DHN
| Bovine glutamate dehydrogenase complexed with Eu3+ | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
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6DQG
| Human glutamate dehydrogenase, H454Y mutant | Descriptor: | Glutamate dehydrogenase 1, mitochondrial, PHOSPHATE ION | Authors: | Smith, T.J. | Deposit date: | 2018-06-10 | Release date: | 2018-06-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Glutamate dehydrogenase: Structure of a hyperinsulinism mutant, corrections to the atomic model, and insights into a regulatory site. Proteins, 87, 2019
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3JD0
| Glutamate dehydrogenase in complex with GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, mitochondrial | Authors: | Borgnia, M.J, Banerjee, S, Merk, A, Matthies, D, Bartesaghi, A, Rao, P, Pierson, J, Earl, L.A, Falconieri, V, Subramaniam, S, Milne, J.L.S. | Deposit date: | 2016-03-28 | Release date: | 2016-04-27 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. Mol.Pharmacol., 89, 2016
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3JD4
| Glutamate dehydrogenase in complex with NADH and GTP, closed conformation | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, ... | Authors: | Borgnia, M.J, Banerjee, S, Merk, A, Matthies, D, Bartesaghi, A, Rao, P, Pierson, J, Earl, L.A, Falconieri, V, Subramaniam, S, Milne, J.L.S. | Deposit date: | 2016-03-28 | Release date: | 2016-04-27 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. Mol.Pharmacol., 89, 2016
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3K92
| Crystal structure of a E93K mutant of the majour Bacillus subtilis glutamate dehydrogenase RocG | Descriptor: | DI(HYDROXYETHYL)ETHER, NAD-specific glutamate dehydrogenase | Authors: | Gunka, K, Newman, J.A, Commichau, F.M, Herzberg, C, Rodrigues, C, Hewitt, L, Lewis, R.J, Stulke, J. | Deposit date: | 2009-10-15 | Release date: | 2010-06-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Functional dissection of a trigger enzyme: mutations of the bacillus subtilis glutamate dehydrogenase RocG that affect differentially its catalytic activity and regulatory properties J.Mol.Biol., 400, 2010
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