Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1OY8
DownloadVisualize
BU of 1oy8 by Molmil
Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump
Descriptor: Acriflavine resistance protein B, RHODAMINE 6G
Authors:Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E.
Deposit date:2003-04-03
Release date:2003-05-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.63 Å)
Cite:Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
3D9B
DownloadVisualize
BU of 3d9b by Molmil
Symmetric structure of E. coli AcrB
Descriptor: Acriflavine resistance protein B, NICKEL (II) ION
Authors:Veesler, D, Blangy, S, Cambillau, C, Sciara, G.
Deposit date:2008-05-27
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:There is a baby in the bath water: AcrB contamination is a major problem in membrane-protein crystallization.
Acta Crystallogr.,Sect.F, 64, 2008
1T9U
DownloadVisualize
BU of 1t9u by Molmil
Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump
Descriptor: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Acriflavine resistance protein B
Authors:Yu, E.W, McDermott, G, Nikaido, H.
Deposit date:2004-05-18
Release date:2005-10-04
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study
J.Bacteriol., 187, 2005
1T9V
DownloadVisualize
BU of 1t9v by Molmil
Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump
Descriptor: Acriflavine resistance protein B, RHODAMINE 6G
Authors:Yu, E.W, McDermott, G, Nikaido, H.
Deposit date:2004-05-18
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study
J.Bacteriol., 187, 2005
1T9W
DownloadVisualize
BU of 1t9w by Molmil
Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump
Descriptor: 6-[[(2-ETHOXY-1-NAPHTHALENYL)CARBONYL]AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE, Acriflavine resistance protein B
Authors:Yu, E.W, McDermott, G, Nikaido, H.
Deposit date:2004-05-18
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study
J.Bacteriol., 187, 2005
1T9X
DownloadVisualize
BU of 1t9x by Molmil
Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump
Descriptor: Acriflavine resistance protein B, ETHIDIUM
Authors:Yu, E.W, McDermott, G, Nikaido, H.
Deposit date:2004-05-19
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study
J.Bacteriol., 187, 2005
7O3M
DownloadVisualize
BU of 7o3m by Molmil
Crystal Structure of AcrB Single Mutant - 1
Descriptor: DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter
Authors:Ababou, A.
Deposit date:2021-04-02
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.551 Å)
Cite:Crystal Structure of AcrB Single Mutant - 1
To Be Published
7O3L
DownloadVisualize
BU of 7o3l by Molmil
Crystal Structure of AcrB Double Mutant
Descriptor: DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter
Authors:Ababou, A.
Deposit date:2021-04-02
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.526 Å)
Cite:Crystal Structure of AcrB Double Mutant
To Be Published
1T9T
DownloadVisualize
BU of 1t9t by Molmil
Structural Basis of Multidrug transport by the AcrB Multidrug Efflux Pump
Descriptor: Acriflavine resistance protein B
Authors:Yu, E.W, McDermott, G, Nikaido, H.
Deposit date:2004-05-18
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study
J.Bacteriol., 187, 2005
7O3N
DownloadVisualize
BU of 7o3n by Molmil
Crystal Structure of AcrB Single Mutant - 2
Descriptor: DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter
Authors:Ababou, A.
Deposit date:2021-04-02
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.561 Å)
Cite:Crystal Structure of AcrB Single Mutant - 2
To Be Published
1T9Y
DownloadVisualize
BU of 1t9y by Molmil
Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump
Descriptor: Acriflavine resistance protein B, N2-(L-PHENYLALANYL)-N1-(NAPHTHALENYL)-L-ARIGNINAMIDE
Authors:Yu, E.W, McDermott, G, Nikaido, H.
Deposit date:2004-05-19
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study
J.Bacteriol., 187, 2005
7OUK
DownloadVisualize
BU of 7ouk by Molmil
BDM88855 inhibitor bound to the transmembrane domain of AcrB
Descriptor: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ...
Authors:Tam, H.K, Foong, W.E, Pos, K.M.
Deposit date:2021-06-12
Release date:2021-12-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun, 13, 2022
7OUL
DownloadVisualize
BU of 7oul by Molmil
BDM88832 inhibitor bound to the transmembrane domain of AcrB-R971A
Descriptor: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 1-(3-chloranyl-5-iodanyl-pyridin-2-yl)piperazine, ...
Authors:Tam, H.K, Foong, W.E, Pos, K.M.
Deposit date:2021-06-12
Release date:2021-12-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun, 13, 2022
7OUM
DownloadVisualize
BU of 7oum by Molmil
BDM88855 inhibitor bound to the transmembrane domain of AcrB-R971A
Descriptor: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 3-chloranyl-2-piperazin-1-yl-quinoline, ...
Authors:Tam, H.K, Foong, W.E, Pos, K.M.
Deposit date:2021-06-12
Release date:2021-12-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun, 13, 2022
3W9I
DownloadVisualize
BU of 3w9i by Molmil
Structural basis for the inhibition of bacterial multidrug exporters
Descriptor: DODECYL-BETA-D-MALTOSIDE, Multidrug resistance protein MexB
Authors:Sakurai, K, Nakashima, R, Hayashi, K, Yamaguchi, A.
Deposit date:2013-04-04
Release date:2013-07-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural basis for the inhibition of bacterial multidrug exporters
Nature, 500, 2013
3W9J
DownloadVisualize
BU of 3w9j by Molmil
Structural basis for the inhibition of bacterial multidrug exporters
Descriptor: DODECYL-BETA-D-MALTOSIDE, Multidrug resistance protein MexB, [{2-[({[(3R)-1-{8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-4-oxo-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}piperidin-3-yl]oxy}carbonyl)amino]ethyl}(dimethyl)ammonio]acetate
Authors:Sakurai, K, Nakashima, R, Hayashi, K, Yamaguchi, A.
Deposit date:2013-04-04
Release date:2013-07-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis for the inhibition of bacterial multidrug exporters
Nature, 500, 2013
3W9H
DownloadVisualize
BU of 3w9h by Molmil
Structural basis for the inhibition of bacterial multidrug exporters
Descriptor: Acriflavine resistance protein B, [{2-[({[(3R)-1-{8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-4-oxo-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}piperidin-3-yl]oxy}carbonyl)amino]ethyl}(dimethyl)ammonio]acetate
Authors:Sakurai, K, Nagata, C, Nakashima, R, Yamaguchi, A.
Deposit date:2013-04-04
Release date:2013-07-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural basis for the inhibition of bacterial multidrug exporters
Nature, 500, 2013
5ENP
DownloadVisualize
BU of 5enp by Molmil
MBX2931 bound structure of bacterial efflux pump.
Descriptor: 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ENQ
DownloadVisualize
BU of 5enq by Molmil
MBX3132 bound structure of bacterial efflux pump.
Descriptor: DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]ethanamide
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ENT
DownloadVisualize
BU of 5ent by Molmil
Minocycline bound structure of bacterial efflux pump.
Descriptor: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ...
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ENR
DownloadVisualize
BU of 5enr by Molmil
MBX3135 bound structure of bacterial efflux pump.
Descriptor: DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{S})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]prop-2-enamide
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ENO
DownloadVisualize
BU of 5eno by Molmil
MBX2319 bound structure of bacterial efflux pump.
Descriptor: 3,3-dimethyl-8-morpholin-4-yl-6-(2-phenylethylsulfanyl)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ENS
DownloadVisualize
BU of 5ens by Molmil
Rhodamine bound structure of bacterial efflux pump.
Descriptor: DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, RHODAMINE 6G
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EN5
DownloadVisualize
BU of 5en5 by Molmil
Apo structure of bacterial efflux pump.
Descriptor: DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB
Authors:Sjuts, H, Ornik, A.R, Pos, K.M.
Deposit date:2015-11-09
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
2GIF
DownloadVisualize
BU of 2gif by Molmil
Asymmetric structure of trimeric AcrB from Escherichia coli
Descriptor: Acriflavine resistance protein B, CITRATE ANION
Authors:Seeger, M.A, Schiefner, A, Eicher, T, Verrey, F, Diederichs, K, Pos, K.M.
Deposit date:2006-03-28
Release date:2006-09-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism.
Science, 313, 2006

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon