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5AJ2
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BU of 5aj2 by Molmil
Cryo electron tomography of the Naip5-Nlrc4 inflammasome
Descriptor: NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4
Authors:Diebolder, C.A, Halff, E.F, Koster, A.J, Huizinga, E.G, Koning, R.I.
Deposit date:2015-02-20
Release date:2015-11-11
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (40 Å)
Cite:Cryoelectron Tomography of the Naip5/Nlrc4 Inflammasome: Implications for Nlr Activation.
Structure, 23, 2015
3LQQ
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BU of 3lqq by Molmil
Structure of the CED-4 Apoptosome
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION
Authors:Qi, S, Pang, Y, Shi, Y, Yan, N, Liu, Q.
Deposit date:2010-02-09
Release date:2010-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.534 Å)
Cite:Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.
Cell(Cambridge,Mass.), 141, 2010
3LQR
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BU of 3lqr by Molmil
Structure of CED-4:CED-3 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION
Authors:Qi, S, Pang, Y, Shi, Y, Yan, N.
Deposit date:2010-02-09
Release date:2010-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.896 Å)
Cite:Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.
Cell(Cambridge,Mass.), 141, 2010
2KN6
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BU of 2kn6 by Molmil
Structure of full-length human ASC (Apoptosis-associated speck-like protein containing a CARD)
Descriptor: Apoptosis-associated speck-like protein containing a CARD
Authors:De Alba, E.
Deposit date:2009-08-16
Release date:2009-09-15
Last modified:2011-11-16
Method:SOLUTION NMR
Cite:Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC)
J.Biol.Chem., 284, 2009
5GPQ
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BU of 5gpq by Molmil
Crystal Structure of zebrafish ASC CARD Domain
Descriptor: CITRIC ACID, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Jin, T, Li, Y.
Deposit date:2016-08-04
Release date:2017-08-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional and structural characterization of zebrafish ASC.
FEBS J., 285, 2018
8JOL
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BU of 8jol by Molmil
cryo-EM structure of the CED-4/CED-3 holoenzyme
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 3, Cell death protein 4, ...
Authors:Li, Y, Tian, L, Zhang, Y, Shi, Y.
Deposit date:2023-06-07
Release date:2023-06-28
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
8JNS
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BU of 8jns by Molmil
cryo-EM structure of a CED-4 hexamer
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION
Authors:Li, Y, Shi, Y.
Deposit date:2023-06-06
Release date:2023-06-28
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
8JO0
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BU of 8jo0 by Molmil
The Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION
Authors:Li, Y, Shi, Y.
Deposit date:2023-06-06
Release date:2023-06-28
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
8FW2
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BU of 8fw2 by Molmil
Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry
Descriptor: NLR family CARD domain-containing protein 4
Authors:Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S.
Deposit date:2023-01-20
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
8FVU
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BU of 8fvu by Molmil
Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1, Lethal factor,Type III secretion system protein, ...
Authors:Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S.
Deposit date:2023-01-19
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
8FW9
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BU of 8fw9 by Molmil
Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry
Descriptor: NLR family CARD domain-containing protein 4
Authors:Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S.
Deposit date:2023-01-20
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (4.46 Å)
Cite:Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
1Z6T
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BU of 1z6t by Molmil
Structure of the apoptotic protease-activating factor 1 bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Apoptotic protease activating factor 1
Authors:Riedl, S.J, Li, W, Chao, Y, Schwarzenbacher, R, Shi, Y.
Deposit date:2005-03-23
Release date:2005-04-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the apoptotic protease-activating factor 1 bound to ADP
Nature, 434, 2005
3T6P
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BU of 3t6p by Molmil
IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization
Descriptor: Baculoviral IAP repeat-containing protein 2, ZINC ION
Authors:Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J.
Deposit date:2011-07-28
Release date:2011-11-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science, 334, 2011
6B5B
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BU of 6b5b by Molmil
Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome
Descriptor: Baculoviral IAP repeat-containing protein 1e, Flagellin, NLR family CARD domain-containing protein 4
Authors:Tenthorey, J.L, Haloupek, N, Lopez-Blanco, J.R, Grob, P, Adamson, E, Hartenian, E, Lind, N.A, Bourgeois, N.M, Chacon, P, Nogales, E, Vance, R.E.
Deposit date:2017-09-29
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
Science, 358, 2017
4KXF
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BU of 4kxf by Molmil
Crystal structure of NLRC4 reveals its autoinhibition mechanism
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NLR family CARD domain-containing protein 4, SULFATE ION
Authors:Chai, J, Hu, Z.
Deposit date:2013-05-25
Release date:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of NLRC4 reveals its autoinhibition mechanism
Science, 341, 2013
4M9Z
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BU of 4m9z by Molmil
Crystal structure of CED-4 bound CED-3 fragment
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ...
Authors:Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9S
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BU of 4m9s by Molmil
crystal structure of CED-4 bound CED-3 fragment
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ...
Authors:Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.207 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9X
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BU of 4m9x by Molmil
Crystal structure of CED-4 bound CED-3 fragment
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ...
Authors:Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.344 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9Y
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BU of 4m9y by Molmil
Crystal structure of CED-4 bound CED-3 fragment
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ...
Authors:Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4IFP
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BU of 4ifp by Molmil
X-ray Crystal Structure of Human NLRP1 CARD Domain
Descriptor: MALONATE ION, Maltose-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 1, ...
Authors:Jin, T, Curry, J, Smith, P, Jiang, J, Xiao, T.
Deposit date:2012-12-14
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9948 Å)
Cite:Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1.
Proteins, 81, 2013
4IKM
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BU of 4ikm by Molmil
X-ray structure of CARD8 CARD domain
Descriptor: 1,2-ETHANEDIOL, IODIDE ION, Maltose-binding periplasmic protein, ...
Authors:Jin, T, Huang, M, Smith, P, Jiang, J, Xiao, T.
Deposit date:2012-12-26
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4606 Å)
Cite:The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.
Acta Crystallogr.,Sect.F, 69, 2013
4IRL
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BU of 4irl by Molmil
X-ray structure of the CARD domain of zebrafish GBP-NLRP1 like protein
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Jin, T, Huang, M, Smith, P, Xiao, T.
Deposit date:2013-01-15
Release date:2013-08-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein.
Acta Crystallogr.,Sect.F, 69, 2013
6KI0
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BU of 6ki0 by Molmil
Crystal Structure of Human ASC-CARD
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Xu, Z.H, Jin, T.C.
Deposit date:2019-07-16
Release date:2020-07-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.
Cell Death Dis, 12, 2021
6MKS
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BU of 6mks by Molmil
Cryo-EM structure of NLRC4-CARD filament
Descriptor: Chimera protein of NLR family CARD domain-containing protein 4 and EGFP
Authors:Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H.
Deposit date:2018-09-26
Release date:2018-11-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.
J. Biol. Chem., 293, 2018
7BKP
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BU of 7bkp by Molmil
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ...
Authors:Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y.
Deposit date:2021-01-16
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021

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