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4YOE
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BU of 4yoe by Molmil
Structure of UP1 bound to RNA 5'-AGU-3'
Descriptor: ACETATE ION, Heterogeneous nuclear ribonucleoprotein A1, RNA AGU, ...
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2015-03-11
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein.
J.Mol.Biol., 427, 2015
4YB1
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BU of 4yb1 by Molmil
20A Mutant c-di-GMP Vc2 Riboswitch bound with 3',3'-cGAMP
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, MAGNESIUM ION, RNA (91-MER), ...
Authors:Ren, A.M, Patel, D.J, Rajashankar, R.K.
Deposit date:2015-02-18
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.081 Å)
Cite:Structural Basis for Molecular Discrimination by a 3',3'-cGAMP Sensing Riboswitch.
Cell Rep, 11, 2015
6SR7
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BU of 6sr7 by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/K98W
Descriptor: SULFATE ION, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-05
Release date:2020-05-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
4Z2X
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BU of 4z2x by Molmil
Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from mouse at 2.15 A resolution
Descriptor: Splicing factor U2AF 65 kDa subunit
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2015-03-30
Release date:2015-04-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from mouse at 2.15 A resolution
To be published
6SXW
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BU of 6sxw by Molmil
Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
Descriptor: SULFATE ION, Zinc finger protein 638
Authors:Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-09-26
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
To Be Published
6SQQ
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BU of 6sqq by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant in complex with RNA obtained by soaking
Descriptor: MAGNESIUM ION, RNA hairpin, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQV
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BU of 6sqv by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/R70W
Descriptor: SULFATE ION, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQT
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BU of 6sqt by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQN
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BU of 6sqn by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant co-crystallized with RNA
Descriptor: RNA hairpin, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
4ZKA
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BU of 4zka by Molmil
High Resolution Crystal Structure of Fox1 RRM
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, RNA binding protein fox-1 homolog 1, SULFATE ION, ...
Authors:Blatter, M, Allain, F.H.-T.
Deposit date:2015-04-30
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High Resolution Crystal Structure of Fox1 RRM
To Be Published
6SNJ
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BU of 6snj by Molmil
Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snRNA stem loop III
Descriptor: RNA-binding protein FUS, U1 snRNA stem loop III, RNA (28-MER)
Authors:Campagne, S, Allain, F.H.
Deposit date:2019-08-26
Release date:2020-10-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Nat Commun, 11, 2020
6TR0
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BU of 6tr0 by Molmil
Solution structure of U2AF2 RRM1,2
Descriptor: Splicing factor U2AF 65 kDa subunit
Authors:Kang, H.-S, Sattler, M.
Deposit date:2019-12-17
Release date:2020-05-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
Proc.Natl.Acad.Sci.USA, 117, 2020
6N3E
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BU of 6n3e by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
Descriptor: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6N3F
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BU of 6n3f by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Leach, J.R, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6NSX
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BU of 6nsx by Molmil
Yeast Hsh155 Ligand bound to Human Tat-SF1 Motif
Descriptor: CHLORIDE ION, HIV Tat-specific factor 1, Hsh155
Authors:Jenkins, J.L, Leach, J.R, Kielkopf, C.L.
Deposit date:2019-01-25
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction.
Rna, 25, 2019
6NTY
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BU of 6nty by Molmil
2.1 A resolution structure of the Musashi-2 (Msi2) RNA recognition motif 1 (RRM1) domain
Descriptor: PHOSPHATE ION, RNA-binding protein Musashi homolog 2
Authors:Lovell, S, Kashipathy, M.M, Battaile, K.P, Lan, L, Xiaoqing, W, Cooper, A, Gao, F.P, Xu, L.
Deposit date:2019-01-30
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.
Proteins, 88, 2020
6NWW
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BU of 6nww by Molmil
Crystal structure of the RRM domain of S. pombe Puf1 in the P212121 space group
Descriptor: CHLORIDE ION, Pumilio domain-containing protein C56F2.08c
Authors:Qiu, C, Hall, T.M.T.
Deposit date:2019-02-07
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity.
Nucleic Acids Res., 47, 2019
6NX5
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BU of 6nx5 by Molmil
Crystal structure of the RRM domain of S. pombe Puf1 in the P21 space group
Descriptor: 1,2-ETHANEDIOL, Pumilio domain-containing protein C56F2.08c
Authors:Qiu, C, Hall, T.M.T.
Deposit date:2019-02-08
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity.
Nucleic Acids Res., 47, 2019
7OCX
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BU of 7ocx by Molmil
Crystal Structure of the PID-3 TOFU-6 RRM domain complex
Descriptor: Embryonic developmental protein tofu-6, Protein pid-3
Authors:Basquin, J, Ketting, R.F, Falk, S.
Deposit date:2021-04-28
Release date:2021-08-25
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans .
Genes Dev., 35, 2021
6Q2I
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BU of 6q2i by Molmil
Solution state NMR structures of the RNA recognition motif (RRM) domain of human CstF-64
Descriptor: Cleavage stimulation factor subunit 2
Authors:Latham, M.P, Masoumzadeh, E.
Deposit date:2019-08-08
Release date:2020-08-12
Last modified:2021-02-24
Method:SOLUTION NMR
Cite:A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3' end processing is associated with intellectual disability in humans.
Nucleic Acids Res., 48, 2020
5OBN
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BU of 5obn by Molmil
NMR solution structure of U11/U12 65K protein's C-terminal RRM domain (381-516)
Descriptor: RNA-binding protein 40
Authors:Norppa, A.J, Kauppala, T.M, Heikkinen, H.A, Verma, B, Iwai, H, Frilander, M.J.
Deposit date:2017-06-28
Release date:2018-01-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.
RNA, 24, 2018
5O3J
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BU of 5o3j by Molmil
Crystal structure of TIA-1 RRM2 in complex with RNA
Descriptor: Nucleolysin TIA-1 isoform p40, RNA (5'-R(P*UP*UP*C)-3')
Authors:Sonntag, M, Jagtap, P.K.A, Hennig, J, Sattler, M.
Deposit date:2017-05-24
Release date:2017-07-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O2V
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BU of 5o2v by Molmil
NMR structure of TIA-1 RRM1 domain
Descriptor: Nucleolysin TIA-1 isoform p40
Authors:Jagtap, P.K.A.
Deposit date:2017-05-22
Release date:2017-06-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Angew. Chem. Int. Ed. Engl., 56, 2017
3G8S
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BU of 3g8s by Molmil
Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme
Descriptor: GLMS RIBOZYME, MAGNESIUM ION, RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3'), ...
Authors:Strobel, S.A, Cochrane, J.C, Lipchock, S.V, Smith, K.D.
Deposit date:2009-02-12
Release date:2009-11-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme
Biochemistry, 48, 2009
5BJR
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BU of 5bjr by Molmil
Crystal structure of the N-terminal RRM domain from MEC-8
Descriptor: AMMONIUM ION, Mec-8 protein
Authors:Soufari, H, Mackereth, C.D.
Deposit date:2016-10-22
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
RNA, 23, 2017

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