PDB: 591 resultsInfo pagesStatus searchChemie searchBIRD

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3IN8	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide Authors: Benfield, A.P, Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic Descriptor: (1R,2S,3R,1S',1S")Phosphoric acid mono(4-{2-[1-(1,2-dicarbamoylethylcarbamoyl)-3-carbamoylpropylcarbamoyl]-3-methylcarbamoylcyclopropyl}phenyl) ester, Growth factor receptor-bound protein 2 Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide Descriptor: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... Authors: Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide Descriptor: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION Authors: Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... Authors: Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide Authors: Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMD	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3K2M	Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex Descriptor: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Duguid, E. Deposit date: 2009-09-30 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17, 2010
8CZ9	Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide Descriptor: CHLORIDE ION, JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2022-05-24 Release date: 2023-05-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity. J.Exp.Med., 221, 2024
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-10-27 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 Authors: Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. Deposit date: 2010-03-24 Release date: 2010-05-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
1TZE	SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2) Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 Authors: Rahuel, J, Grutter, M.G. Deposit date: 1996-06-06 Release date: 1997-07-07 Last modified: 2011-11-16 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996
1WQU	Solution structure of the human FES SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase FES/FPS Authors: Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-10-02 Release date: 2005-06-14 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
1X0N	NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor Descriptor: 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 Authors: Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. Deposit date: 2005-03-24 Release date: 2005-04-19 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor To be Published
1X6C	Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 Descriptor: Tyrosine-protein phosphatase, non-receptor type 6 Authors: Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-17 Release date: 2005-11-17 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
4EIH	Crystal structure of Arg SH2 domain Descriptor: Abelson tyrosine-protein kinase 2, CHLORIDE ION Authors: Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. Deposit date: 2012-04-05 Release date: 2013-04-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
4EY0	Structure of tandem SH2 domains from PLCgamma1 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-01 Release date: 2012-10-31 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
4F5A	Triple mutant Src SH2 domain bound to phosphate ion Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F59	Triple mutant Src SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5B	Triple mutant Src SH2 domain bound to phosphotyrosine Descriptor: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4FBN	Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-23 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
1ZFP	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION Authors: Rahuel, J. Deposit date: 1998-03-26 Release date: 1999-03-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
4XZ0	ZAP-70-tSH2:compound-A complex Descriptor: 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, Tyrosine-protein kinase ZAP-70 Authors: Barros, T, Kuriyan, J, Visperas, P.R, Winger, J.A. Deposit date: 2015-02-03 Release date: 2015-06-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
5AUL	PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 Authors: Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. Deposit date: 2015-04-28 Release date: 2016-05-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017

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