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7SMD
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BU of 7smd by Molmil
p107 pocket domain complexed with EID1 peptide
Descriptor: EP300-interacting inhibitor of differentiation 1, Retinoblastoma-like protein 1, SULFATE ION
Authors:Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M.
Deposit date:2021-10-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Structure, 30, 2022
7SS8
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BU of 7ss8 by Molmil
Human P300 complexed with a proline-based inhibitor
Descriptor: 1,2-ETHANEDIOL, 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-{[3-(methylcarbamoyl)phenyl]methyl}-D-prolinamide, Histone acetyltransferase p300, ...
Authors:Shewchuk, L.M, Reid, R.A.
Deposit date:2021-11-10
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
7SSK
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BU of 7ssk by Molmil
Human P300 complexed with a glycine-based inhibitor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Histone acetyltransferase p300, ...
Authors:Shewchuk, L.M, Reid, R.A.
Deposit date:2021-11-11
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
7SZQ
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BU of 7szq by Molmil
Human P300 complexed with an azaindazole inhibitor
Descriptor: 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide, Histone acetyltransferase p300
Authors:Shewchuk, L.M, Reid, R.A.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
6FGN
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BU of 6fgn by Molmil
Solution Structure of p300Taz2-p63TA
Descriptor: Histone acetyltransferase p300,Tumor protein 63, ZINC ION
Authors:Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V.
Deposit date:2018-01-11
Release date:2018-05-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
6FGS
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BU of 6fgs by Molmil
Solution structure of p300Taz2-p73TA1
Descriptor: Histone acetyltransferase p300,Tumor protein p73, ZINC ION
Authors:Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V.
Deposit date:2018-01-11
Release date:2018-05-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
4PZT
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BU of 4pzt by Molmil
Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A
Descriptor: DIMETHYL SULFOXIDE, Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE
Authors:Maksimoska, J, Marmorstein, R.
Deposit date:2014-03-31
Release date:2014-06-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues.
Biochemistry, 53, 2014
4PZR
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BU of 4pzr by Molmil
Crystal structure of p300 histone acetyltransferase domain in complex with Coenzyme A
Descriptor: COENZYME A, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Maksimoska, J, Marmorstein, R.
Deposit date:2014-03-31
Release date:2014-06-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues.
Biochemistry, 53, 2014
2K8F
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BU of 2k8f by Molmil
Structural Basis for the Regulation of p53 Function by p300
Descriptor: Cellular tumor antigen p53, Histone acetyltransferase p300
Authors:Bai, Y, Feng, H, Jenkins, L.M, Durell, S.R, Wiodawer, A, Appella, E.
Deposit date:2008-09-08
Release date:2009-03-03
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation.
Structure, 17, 2009
7LJE
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BU of 7lje by Molmil
Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Descriptor: 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide, Histone acetyltransferase p300
Authors:Jakob, C.G.
Deposit date:2021-01-29
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.607 Å)
Cite:Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.
Bioorg.Med.Chem.Lett., 39, 2021
8HAH
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BU of 8hah by Molmil
Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (3.9 angstrom resolution)
Descriptor: DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T.
Deposit date:2022-10-26
Release date:2023-05-17
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
8HAG
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BU of 8hag by Molmil
Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (3.2 angstrom resolution)
Descriptor: DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T.
Deposit date:2022-10-26
Release date:2023-05-17
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
8HAJ
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BU of 8haj by Molmil
Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (4.8 angstrom resolution)
Descriptor: DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T.
Deposit date:2022-10-26
Release date:2023-05-17
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
8HAI
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BU of 8hai by Molmil
Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (4.7 angstrom resolution)
Descriptor: DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T.
Deposit date:2022-10-26
Release date:2023-05-17
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
8HAK
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BU of 8hak by Molmil
Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 4 (4.5 angstrom resolution)
Descriptor: DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T.
Deposit date:2022-10-26
Release date:2023-05-17
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
5XZC
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BU of 5xzc by Molmil
Cryo-EM structure of p300-p53 protein complex
Descriptor: Cellular tumor antigen p53, Histone acetyltransferase p300
Authors:Ghosh, R, Roy, S, Sengupta, J.
Deposit date:2017-07-12
Release date:2019-01-23
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (10.7 Å)
Cite:Tumor suppressor p53-mediated structural reorganization of the transcriptional coactivator p300.
Biochemistry, 2019
3P57
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BU of 3p57 by Molmil
Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA
Descriptor: DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ...
Authors:He, J, Ye, J, Riquelme, C, Liu, J.O.
Deposit date:2010-10-08
Release date:2011-08-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1921 Å)
Cite:Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
3BIY
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BU of 3biy by Molmil
Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Descriptor: BROMIDE ION, Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
Authors:Liu, X, Wang, L, Zhao, K, Thompson, P.R, Hwang, Y, Marmorstein, R, Cole, P.A.
Deposit date:2007-12-02
Release date:2008-02-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
Nature, 451, 2008
5KJ2
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BU of 5kj2 by Molmil
The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer
Descriptor: Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION
Authors:Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C.
Deposit date:2016-06-17
Release date:2017-09-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature, 550, 2017
5LKX
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BU of 5lkx by Molmil
Crystal structure of the p300 acetyltransferase catalytic core with propionyl-coenzyme A.
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase p300,Histone acetyltransferase p300, ...
Authors:Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D.
Deposit date:2016-07-25
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structure of p300 in complex with acyl-CoA variants.
Nat. Chem. Biol., 13, 2017
5LKT
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BU of 5lkt by Molmil
Crystal structure of the p300 acetyltransferase catalytic core with butyryl-coenzyme A.
Descriptor: Butyryl Coenzyme A, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D.
Deposit date:2016-07-24
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure of p300 in complex with acyl-CoA variants.
Nat. Chem. Biol., 13, 2017
5LKZ
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BU of 5lkz by Molmil
Crystal structure of the p300 acetyltransferase catalytic core with crotonyl-coenzyme A.
Descriptor: CROTONYL COENZYME A, GLYCEROL, Histone acetyltransferase p300,Histone acetyltransferase p300, ...
Authors:Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D.
Deposit date:2016-07-25
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of p300 in complex with acyl-CoA variants.
Nat. Chem. Biol., 13, 2017
5LKU
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BU of 5lku by Molmil
Crystal structure of the p300 acetyltransferase catalytic core with coenzyme A.
Descriptor: COENZYME A, Histone acetyltransferase p300,Histone acetyltransferase p300, ZINC ION
Authors:Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D.
Deposit date:2016-07-25
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of p300 in complex with acyl-CoA variants.
Nat. Chem. Biol., 13, 2017
7W9V
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BU of 7w9v by Molmil
Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I)
Descriptor: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Hatazawa, S, Liu, J, Takizawa, Y, Zandian, M, Negishi, L, Kutateladze, T.G, Kurumizaka, H.
Deposit date:2021-12-10
Release date:2022-07-13
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structural basis for binding diversity of acetyltransferase p300 to the nucleosome.
Iscience, 25, 2022
7XFG
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BU of 7xfg by Molmil
NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #1
Descriptor: Histone acetyltransferase p300, NUT family member 1, ZINC ION
Authors:Yu, D, Zeng, L, Zhou, M.-M.
Deposit date:2022-04-01
Release date:2023-04-12
Method:SOLUTION NMR
Cite:Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation
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