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2VDE
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BU of 2vde by Molmil
Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps
Descriptor: CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC
Authors:Bavro, V.N, Pietras, Z, Furnham, N, Perez-Cano, L, Fernandez-Recio, J, Pei, X.Y, Truer, R, Misra, R, Luisi, B.
Deposit date:2007-10-04
Release date:2008-04-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Assembly and Channel Opening in a Bacterial Drug Efflux Machine.
Mol.Cell, 30, 2008
2VDD
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BU of 2vdd by Molmil
Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps
Descriptor: CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC, POTASSIUM ION
Authors:Bavro, V.N, Pietras, Z, Furnham, N, Perez-Cano, L, Fernandez-Recio, J, Pei, X.Y, Truer, R, Misra, R, Luisi, B.
Deposit date:2007-10-04
Release date:2008-04-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Assembly and Channel Opening in a Bacterial Drug Efflux Machine.
Mol.Cell, 30, 2008
2WMZ
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BU of 2wmz by Molmil
Structure of a mutated TolC
Descriptor: CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC, SODIUM ION, ...
Authors:Hinchliffe, P, Pei, X.Y, Symmons, M.F, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2009-07-03
Release date:2011-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of Sequential Open States in a Symmetrical Opening Transition of the Tolc Exit Duct.
Proc.Natl.Acad.Sci.USA, 108, 2011
2XMN
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BU of 2xmn by Molmil
High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices
Descriptor: CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Outer membrane protein TolC
Authors:Pei, X.Y, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2010-07-28
Release date:2011-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.
Proc. Natl. Acad. Sci. U.S.A., 108, 2011
5V5S
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BU of 5v5s by Molmil
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Descriptor: Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, Outer membrane protein TolC
Authors:wang, Z, fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D.
Deposit date:2017-03-15
Release date:2017-04-19
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Elife, 6, 2017
5O66
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BU of 5o66 by Molmil
Asymmetric AcrABZ-TolC
Descriptor: Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, ...
Authors:Du, D, Luisi, B.F.
Deposit date:2017-06-05
Release date:2017-06-14
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump.
Elife, 6, 2017
6IOL
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BU of 6iol by Molmil
Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)
Descriptor: Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM
Authors:Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E.
Deposit date:2018-10-30
Release date:2019-04-03
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Nat Commun, 10, 2019
6IOK
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BU of 6iok by Molmil
Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state)
Descriptor: Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM
Authors:Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E.
Deposit date:2018-10-30
Release date:2019-04-03
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Nat Commun, 10, 2019
6TA6
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BU of 6ta6 by Molmil
MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs
Descriptor: Efflux pump membrane transporter, MexA family multidrug efflux RND transporter periplasmic adaptor subunit, Outer membrane protein OprM
Authors:Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I.
Deposit date:2019-10-29
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex.
Nat Commun, 11, 2020
6TA5
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BU of 6ta5 by Molmil
OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs
Descriptor: Efflux pump membrane transporter, MexA family multidrug efflux RND transporter periplasmic adaptor subunit, Outer membrane protein OprM
Authors:Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I.
Deposit date:2019-10-29
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex.
Nat Commun, 11, 2020
5NIK
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BU of 5nik by Molmil
Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump
Descriptor: Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC
Authors:Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D.
Deposit date:2017-03-24
Release date:2017-05-24
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.
Nat Microbiol, 2, 2017
5NIL
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BU of 5nil by Molmil
Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump-MacB section
Descriptor: Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC
Authors:Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D.
Deposit date:2017-03-24
Release date:2017-05-24
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.
Nat Microbiol, 2, 2017
5NG5
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BU of 5ng5 by Molmil
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Descriptor: 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ...
Authors:Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D.
Deposit date:2017-03-16
Release date:2017-04-19
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Elife, 6, 2017
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