PDB: 85 resultsInfo pagesStatus searchChemie searchBIRD

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5V8F	Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 Descriptor: Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... Authors: Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. Deposit date: 2017-03-21 Release date: 2017-05-10 Last modified: 2020-04-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
5WY1	Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION Authors: Kanada, K, Takeshita, K, Suetake, I, Tajima, S, Nakagawa, A. Deposit date: 2017-01-10 Release date: 2017-05-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1 J. Biochem., 162, 2017
5GUT	The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... Authors: Chen, S.J, Ye, F. Deposit date: 2016-08-31 Release date: 2017-09-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
6X9I	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... Authors: Pathuri, S, Horton, J.R, Cheng, X. Deposit date: 2020-06-02 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9K	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A Descriptor: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), ... Authors: Pathuri, S, Horton, J.R, Cheng, X. Deposit date: 2020-06-02 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9J	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052 Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... Authors: Pathuri, S, Horton, J.R, Cheng, X. Deposit date: 2020-06-02 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
5GUV	The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION Authors: Ye, F, Chen, S.J. Deposit date: 2016-08-31 Release date: 2017-08-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.078 Å) Cite: Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
3AV4	Crystal structure of mouse DNA methyltransferase 1 Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3AV5	Crystal structure of mouse DNA methyltransferase 1 with AdoHcy Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3AV6	Crystal structure of mouse DNA methyltransferase 1 with AdoMet Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYLMETHIONINE, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
5HH7	crystal structure of Arabidopsis ORC1b BAH-PHD cassette in complex with unmodified H3 peptide Descriptor: Histone H3 1-15 peptide, Origin of replication complex subunit 1B, ZINC ION Authors: Li, S, Du, J. Deposit date: 2016-01-10 Release date: 2016-03-09 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.901 Å) Cite: Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette Structure, 24, 2016
3PT6	Crystal structure of mouse DNMT1(650-1602) in complex with DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PTA	Crystal structure of human DNMT1(646-1600) in complex with DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PT9	Crystal structure of mouse DNMT1(731-1602) in the free state Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
7MCA	Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6 and the ARS1 origin DNA. Descriptor: Cell division control protein 6, DNA (85-MER), MAGNESIUM ION, ... Authors: Feng, X, Li, H. Deposit date: 2021-04-01 Release date: 2021-06-02 Last modified: 2021-08-04 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nat Commun, 12, 2021
4KUD	Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle Descriptor: Histone H2A.2, Histone H2B.1, Histone H3, ... Authors: Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. Deposit date: 2013-05-22 Release date: 2013-08-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.203 Å) Cite: N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
4LD9	Crystal structure of the N-terminally acetylated BAH domain of Sir3 bound to the nucleosome core particle Descriptor: Histone H2A, Histone H2B 1.1, Histone H3.2, ... Authors: Arnaudo, N, Fernandez, I.S, McLaughlin, S.H, Peak-Chew, S.Y, Rhodes, D, Martino, F. Deposit date: 2013-06-24 Release date: 2013-08-14 Last modified: 2013-09-18 Method: X-RAY DIFFRACTION (3.306 Å) Cite: The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle. Nat.Struct.Mol.Biol., 20, 2013
4FSX	crystal structure of Se-substituted Zea mays ZMET2 in complex with SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
4FT4	crystal structure of Zea mays ZMET2 in complex H3(1-32)K9me2 peptide and SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, H3(1-32)K9me2 peptide, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
4FT2	crystal structure of Zea mays ZMET2 in complex H3(1-15)K9me2 peptide and SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, H3 peptide, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
6K15	RSC substrate-recruitment module Descriptor: Chromatin structure-remodeling complex protein RSC3, Chromatin structure-remodeling complex protein RSC30, Chromatin structure-remodeling complex protein RSC58, ... Authors: Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. Deposit date: 2019-05-09 Release date: 2019-11-13 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
6KW3	The ClassA RSC-Nucleosome Complex Descriptor: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... Authors: Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. Deposit date: 2019-09-05 Release date: 2019-11-13 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (7.13 Å) Cite: Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
6KW5	The ClassC RSC-Nucleosome Complex Descriptor: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... Authors: Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. Deposit date: 2019-09-06 Release date: 2020-09-09 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (10.13 Å) Cite: Structure of the RSC complex bound to the nucleosome To Be Published
4DA4	Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA Descriptor: CITRIC ACID, DNA (cytosine-5)-methyltransferase 1, DNA_LOWER_STRAND, ... Authors: Song, J, Patel, D.J. Deposit date: 2012-01-12 Release date: 2012-02-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation. Science, 335, 2012
6KW4	The ClassB RSC-Nucleosome Complex Descriptor: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... Authors: Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. Deposit date: 2019-09-06 Release date: 2019-11-13 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (7.55 Å) Cite: Structure of the RSC complex bound to the nucleosome. Science, 366, 2019

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