3F81
 
 | | Interaction of VHR with SA3 | | Descriptor: | 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid, Dual specificity protein phosphatase 3 | | Authors: | Wu, S, Mutelin, T, Tautz, L. | | Deposit date: | 2008-11-11 | | Release date: | 2009-11-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
J.Med.Chem., 52, 2009
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3EZZ
 | | Crystal Structure of human MKP-2 | | Descriptor: | Dual specificity protein phosphatase 4, SULFATE ION | | Authors: | Jeong, D.G, Jung, S.K, Ryu, S.E, Kim, S.J. | | Deposit date: | 2008-10-24 | | Release date: | 2009-08-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly.
Proteins, 76, 2009
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1RXD
 | | Crystal structure of human protein tyrosine phosphatase 4A1 | | Descriptor: | protein tyrosine phosphatase type IVA, member 1; Protein tyrosine phosphatase IVA1 | | Authors: | Sun, J.P, Fedorov, A.A, Almo, S.C, Zhang, Z.Y, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2003-12-18 | | Release date: | 2004-12-28 | | Last modified: | 2021-02-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural genomics of protein phosphatases.
J.STRUCT.FUNCT.GENOM., 8, 2007
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1M3G
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1MKP
 | | CRYSTAL STRUCTURE OF PYST1 (MKP3) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PYST1 | | Authors: | Stewart, A.E, Dowd, S, Keyse, S, Mcdonald, N.Q. | | Deposit date: | 1998-07-11 | | Release date: | 1999-07-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.
Nat.Struct.Biol., 6, 1999
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4B04
 | | Crystal structure of the Catalytic Domain of Human DUSP26 (C152S) | | Descriptor: | DUAL SPECIFICITY PROTEIN PHOSPHATASE 26 | | Authors: | Won, E.-Y, Lee, D.Y, Park, S.G, Yokoyama, S, Kim, S.J, Chi, S.-W. | | Deposit date: | 2012-06-28 | | Release date: | 2013-05-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.205 Å) | | Cite: | High-Resolution Crystal Structure of the Catalytic Domain of Human Dual-Specificity Phosphatase 26
Acta Crystallogr.,Sect.D, 69, 2013
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4D3R
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4D3Q
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4D3P
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5XJV
 | | Two intermediate states of conformation switch in dual specificity phosphatase 13a | | Descriptor: | Dual specificity protein phosphatase 13 isoform A, PHOSPHATE ION | | Authors: | Wei, C.H, Min, H.G, Chun, H.J, Ryu, S.E. | | Deposit date: | 2017-05-04 | | Release date: | 2018-04-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Two intermediate states of the conformational switch in dual specificity phosphatase 13a
Pharmacol. Res., 128, 2018
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4ERC
 | | Structure of VHZ bound to metavanadate | | Descriptor: | Dual specificity protein phosphatase 23, oxido(dioxo)vanadium | | Authors: | Vyacheslav, K, Alvan, C.H, Sean, J.J. | | Deposit date: | 2012-04-19 | | Release date: | 2012-12-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | New Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate Screening.
Biochemistry, 51, 2012
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5Y15
 | | Crystal structure of human DUSP28 | | Descriptor: | Dual specificity phosphatase 28, PHOSPHATE ION | | Authors: | Ku, B, Hong, W, Kim, S.J, Ryu, S.E. | | Deposit date: | 2017-07-19 | | Release date: | 2017-11-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28
PLoS ONE, 12, 2017
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3RGQ
 | | Crystal Structure of PTPMT1 in complex with PI(5)P | | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, Protein-tyrosine phosphatase mitochondrial 1 | | Authors: | Xiao, J, Engel, J.L. | | Deposit date: | 2011-04-08 | | Release date: | 2011-07-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
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5Y16
 | | Crystal structure of human DUSP28(Y102H) | | Descriptor: | CHLORIDE ION, Dual specificity phosphatase 28, PHOSPHATE ION | | Authors: | Ku, B, Kim, M, Kim, S.J, Ryu, S.E. | | Deposit date: | 2017-07-19 | | Release date: | 2017-11-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.399 Å) | | Cite: | Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28
PLoS ONE, 12, 2017
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3RGO
 | | Crystal Structure of PTPMT1 | | Descriptor: | Protein-tyrosine phosphatase mitochondrial 1, SULFATE ION | | Authors: | Xiao, J, Engel, J.L. | | Deposit date: | 2011-04-08 | | Release date: | 2011-07-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.928 Å) | | Cite: | Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RZ2
 | | Crystal of Prl-1 complexed with peptide | | Descriptor: | Prl-1 (PTP4A1), Protein tyrosine phosphatase type IVA 1 | | Authors: | Zhang, Z.-Y, Liu, D, Bai, Y. | | Deposit date: | 2011-05-11 | | Release date: | 2011-10-26 | | Last modified: | 2014-10-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
J.Biol.Chem., 286, 2011
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3S4E
 | | Crystal Structrue of a Novel Mitogen-activated Protein Kinase Phosphatase, SKRP1 | | Descriptor: | Dual specificity protein phosphatase 19, PHOSPHATE ION, SULFATE ION | | Authors: | Wei, C.H, Ryu, S.Y, Jeon, Y.H, Jeong, D.G, Kim, S.J, Ryu, S.E. | | Deposit date: | 2011-05-19 | | Release date: | 2012-04-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1.
Proteins, 79, 2011
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2NT2
 | | Crystal Structure of Slingshot phosphatase 2 | | Descriptor: | Protein phosphatase Slingshot homolog 2, SULFATE ION | | Authors: | Jung, S.K, Jeong, D.G, Yoon, T.S, Kim, J.H, Ryu, S.E, Kim, S.J. | | Deposit date: | 2006-11-06 | | Release date: | 2007-06-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of human slingshot phosphatase 2.
Proteins, 68, 2007
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2OUD
 | | Crystal structure of the catalytic domain of human MKP5 | | Descriptor: | CHLORIDE ION, Dual specificity protein phosphatase 10 | | Authors: | Tao, X, Tong, L. | | Deposit date: | 2007-02-10 | | Release date: | 2007-08-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.
Protein Sci., 16, 2007
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2PQ5
 | | Crystal structure of Dual specificity protein phosphatase 13 (DUSP13) | | Descriptor: | Dual specificity protein phosphatase 13 | | Authors: | Ugochukwu, E, Salah, E, Savitsky, P, Barr, A, Pantic, N, Niesen, F, Burgess-Brown, N, Berridge, G, Bunkoczi, G, Uppenberg, J, Pike, A.C.W, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-05-01 | | Release date: | 2007-05-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of Dual specificity protein phosphatase 13 (DUSP13).
To be Published
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2Q05
 | | Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR | | Descriptor: | Dual specificity protein phosphatase | | Authors: | Osipiuk, J, Skarina, T, Kagan, O, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-05-18 | | Release date: | 2007-06-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR.
To be Published
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2R0B
 | | Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein | | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine/tyrosine-interacting protein | | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Iizuka, M, Romero, R, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2007-08-18 | | Release date: | 2007-08-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
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2RF6
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2G6Z
 | | Crystal structure of human DUSP5 | | Descriptor: | Dual specificity protein phosphatase 5, SULFATE ION | | Authors: | Kim, S.J, Ryu, S.E. | | Deposit date: | 2006-02-26 | | Release date: | 2007-01-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase
Proteins, 66, 2007
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5Z59
 | | Crystal structure of Tk-PTP in the inactive form | | Descriptor: | Protein-tyrosine phosphatase | | Authors: | Ku, B, Yun, H.Y, Kim, S.J. | | Deposit date: | 2018-01-17 | | Release date: | 2018-06-27 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.703 Å) | | Cite: | Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1
PLoS ONE, 13, 2018
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