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8BNT
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BU of 8bnt by Molmil
The DH domain of ARHGEF2 bound to RhoA
Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ...
Authors:Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E.
Deposit date:2022-11-25
Release date:2022-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The DH domain of ARHGEF2 bound to RhoA
To Be Published
4YON
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BU of 4yon by Molmil
P-Rex1:Rac1 complex
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Lucato, C.M, Whisstock, J.C, Ellisdon, A.M.
Deposit date:2015-03-11
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
4MT6
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BU of 4mt6 by Molmil
Crystal structure of closed inactive collybistin
Descriptor: Rho guanine nucleotide exchange factor 9
Authors:Schneeberger, D, Schindelin, H.
Deposit date:2013-09-19
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (5.501 Å)
Cite:A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
Embo J., 33, 2014
4MT7
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BU of 4mt7 by Molmil
Crystal structure of collybistin I
Descriptor: Rho guanine nucleotide exchange factor 9
Authors:Schneeberger, D, Schindelin, H.
Deposit date:2013-09-19
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
Embo J., 33, 2014
4D0N
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BU of 4d0n by Molmil
AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA
Descriptor: 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
2Z0Q
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BU of 2z0q by Molmil
Crystal structure of DH-PH domain of RhoGEF3(Xpln)
Descriptor: Rho guanine nucleotide exchange factor 3, SULFATE ION
Authors:Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-07
Release date:2008-05-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of the Rho-specific guanine nucleotide-exchange factor Xpln
Acta Crystallogr.,Sect.F, 68, 2012
5FI0
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BU of 5fi0 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1
Descriptor: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.282 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5FI1
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BU of 5fi1 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
Descriptor: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
2DX1
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BU of 2dx1 by Molmil
Crystal structure of RhoGEF protein Asef
Descriptor: Rho guanine nucleotide exchange factor 4
Authors:Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-22
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism
J.Biol.Chem., 282, 2007
1RJ2
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BU of 1rj2 by Molmil
Crystal structure of the DH/PH fragment of Dbs without bound GTPase
Descriptor: Guanine nucleotide exchange factor DBS [Fragment]
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2003-11-18
Release date:2004-06-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure, 12, 2004
2DFK
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BU of 2dfk by Molmil
Crystal structure of the CDC42-Collybistin II complex
Descriptor: GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ...
Authors:Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H.
Deposit date:2006-03-02
Release date:2006-05-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor.
J.Mol.Biol., 359, 2006
7RX9
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BU of 7rx9 by Molmil
Structure of autoinhibited P-Rex1
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION
Authors:Ellisdon, A.M, Chang, Y.
Deposit date:2021-08-22
Release date:2022-08-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
1DBH
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BU of 1dbh by Molmil
DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1
Descriptor: PROTEIN (HUMAN SOS 1)
Authors:Soisson, S.M, Kuriyan, J.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell(Cambridge,Mass.), 95, 1998
7SJ4
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BU of 7sj4 by Molmil
Human Trio residues 1284-1959 in complex with Rac1
Descriptor: Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein
Authors:Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G.
Deposit date:2021-10-15
Release date:2022-07-06
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
J.Biol.Chem., 298, 2022
7SYF
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BU of 7syf by Molmil
Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera
Authors:Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M.
Deposit date:2021-11-24
Release date:2022-07-27
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
2NZ8
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BU of 2nz8 by Molmil
N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1
Descriptor: ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
Authors:Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J.
Deposit date:2006-11-22
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
1FOE
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BU of 1foe by Molmil
CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION, T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
2PZ1
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BU of 2pz1 by Molmil
Crystal Structure of Auto-inhibited Asef
Descriptor: Rho guanine nucleotide exchange factor 4
Authors:Betts, L, Sondek, J, Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
2RGN
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BU of 2rgn by Molmil
Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ...
Authors:Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G.
Deposit date:2007-10-04
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
6L30
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BU of 6l30 by Molmil
Crystal structure of the epithelial cell transforming 2 (ECT2)
Descriptor: Protein ECT2
Authors:Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P.
Deposit date:2019-10-07
Release date:2020-01-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and regulation of human epithelial cell transforming 2 protein.
Proc.Natl.Acad.Sci.USA, 117, 2020
4GZU
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BU of 4gzu by Molmil
Crystal structure of the DH-PH-PH domain of FARP2
Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X, Zhang, X.
Deposit date:2012-09-06
Release date:2013-03-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
4GOU
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BU of 4gou by Molmil
Crystal structure of an RGS-RhoGEF from Entamoeba histolytica
Descriptor: EhRGS-RhoGEF
Authors:Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P.
Deposit date:2012-08-20
Release date:2013-01-09
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
4H6Y
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BU of 4h6y by Molmil
Crystal structure of the DH-PH-PH domain of FARP1
Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 1
Authors:He, X, Zhang, X.
Deposit date:2012-09-19
Release date:2013-03-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.09 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
1KI1
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BU of 1ki1 by Molmil
Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42
Descriptor: G25K GTP-binding protein, placental isoform, SULFATE ION, ...
Authors:Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
6NFA
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BU of 6nfa by Molmil
Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity
Descriptor: (2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol, Proto-oncogene vav, ZINC ION
Authors:Knapp, M.S, Elling, R.A, Ornelas, E.
Deposit date:2018-12-19
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity
To Be Published

217705

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