5XJG
| Crystal structure of Vac8p bound to Nvj1p | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Nucleus-vacuole junction protein 1, ... | Authors: | Jeong, H, Park, J, Jun, Y, Lee, C. | Deposit date: | 2017-05-01 | Release date: | 2017-06-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8Y0G
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8Y14
| Beta-catenin Crystal Structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-01-23 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Beta-catenin Crystal Structure To Be Published
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4DJS
| Structure of beta-catenin in complex with a stapled peptide inhibitor | Descriptor: | Catenin beta-1, stapled peptide RRWPQ(MK8)ILD(MK8)HVRRVWR | Authors: | Bowman, B.R, Grossmann, T.N, Yeh, J.T.-H, Verdine, G.L. | Deposit date: | 2012-02-02 | Release date: | 2012-10-17 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.029 Å) | Cite: | Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin. Proc.Natl.Acad.Sci.USA, 109, 2012
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4EV8
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4EVA
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4R11
| A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo | Descriptor: | Cadherin-related hmr-1, IODIDE ION, Protein humpback-2 | Authors: | Choi, H.-J, Loveless, T, Lynch, A, Bang, I, Hardin, J, Weis, W.I. | Deposit date: | 2014-08-03 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.789 Å) | Cite: | A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo Dev.Cell, 33, 2015
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4R0Z
| A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo | Descriptor: | FORMIC ACID, Protein humpback-2 | Authors: | Choi, H.-J, Loveless, T, Lynch, A, Bang, I, Hardin, J, Weis, W.I. | Deposit date: | 2014-08-03 | Release date: | 2015-04-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.005 Å) | Cite: | A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo Dev.Cell, 33, 2015
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4R10
| A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo | Descriptor: | 1,2-ETHANEDIOL, Cadherin-related hmr-1, Protein humpback-2, ... | Authors: | Choi, H.-J, Loveless, T, Lynch, A, Bang, I, Hardin, J, Weis, W.I. | Deposit date: | 2014-08-03 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo Dev.Cell, 33, 2015
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3SLA
| X-ray structure of first four repeats of human beta-catenin | Descriptor: | Catenin beta-1, GLYCEROL, SODIUM ION | Authors: | Gupta, D, Bienz, M. | Deposit date: | 2011-06-24 | Release date: | 2012-02-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nat Commun, 3, 2012
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3TT9
| Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant | Descriptor: | GLYCEROL, Plakophilin-2 | Authors: | Schuetz, A, Roske, Y, Gerull, B, Heinemann, U. | Deposit date: | 2011-09-14 | Release date: | 2012-08-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet, 5, 2012
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7N9H
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6P6E
| Structure of Mouse Importin alpha - PAC3 NLS peptide complex | Descriptor: | Importin subunit alpha-1, PAC3 NLS | Authors: | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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6P6A
| Structure of Mouse Importin alpha - NIT2 NLS peptide complex | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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1BK6
| KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS | Descriptor: | KARYOPHERIN ALPHA, LARGE T ANTIGEN | Authors: | Conti, E, Uy, M, Leighton, L, Blobel, G, Kuriyan, J. | Deposit date: | 1998-07-14 | Release date: | 1999-01-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell(Cambridge,Mass.), 94, 1998
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1BK5
| KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE | Descriptor: | COBALT (II) ION, KARYOPHERIN ALPHA | Authors: | Conti, E, Uy, M, Leighton, L, Blobel, G, Kuriyan, J. | Deposit date: | 1998-07-14 | Release date: | 1999-01-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell(Cambridge,Mass.), 94, 1998
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2GL7
| Crystal Structure of a beta-catenin/BCL9/Tcf4 complex | Descriptor: | B-cell lymphoma 9 protein, Beta-catenin, Transcription factor 7-like 2 | Authors: | Sampietro, J. | Deposit date: | 2006-04-04 | Release date: | 2006-10-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex. Mol.Cell, 24, 2006
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2JDQ
| C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5 | Descriptor: | IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC PROTEIN 2 | Authors: | Tarendeau, F, Guilligay, D, Mas, P, Boulo, S, Baudin, F, Ruigrok, R.W.H, Hart, D.J, Cusack, S. | Deposit date: | 2007-01-11 | Release date: | 2007-02-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit Nat.Struct.Mol.Biol., 14, 2007
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5K9S
| Importin-alpha in complex with HNF1-beta peptide | Descriptor: | HNF1 beta A splice variant 2, Importin subunit alpha-1 | Authors: | Wiedmann, M.M, Aibara, S, Spring, D.R, Stewart, M, Brenton, J. | Deposit date: | 2016-06-01 | Release date: | 2016-11-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Importin-alpha in complex with HNF1-beta peptide To Be Published
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5KLT
| Prototypical P4[M]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[M]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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5KLR
| Prototypical P4[R]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[R]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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4MZ5
| Structure of importin-alpha: dUTPase NLS complex | Descriptor: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1 | Authors: | Marfori, M, Rona, G, Vertessy, B.G, Kobe, B. | Deposit date: | 2013-09-29 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallogr.,Sect.D, 69, 2013
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4MZ6
| Structure of importin-alpha: dUTPase S11E NLS mutant complex | Descriptor: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1 | Authors: | Marfori, M, Rona, G, Vertessy, B.G, Kobe, B. | Deposit date: | 2013-09-29 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallogr.,Sect.D, 69, 2013
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2C1T
| Structure of the Kap60p:Nup2 complex | Descriptor: | IMPORTIN ALPHA SUBUNIT, NUCLEOPORIN NUP2 | Authors: | Matsuura, Y, Stewart, M. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Nup50/Npap60 Function in Nuclear Import Complex Disassembly and Importin Recycling Embo J., 24, 2005
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2C1M
| Nup50:importin-alpha complex | Descriptor: | IMPORTIN-ALPHA2 SUBUNIT, NUCLEOPORIN 50 KDA | Authors: | Matsuura, Y, Stewart, M. | Deposit date: | 2005-09-16 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Nup50/Npap60 Function in Nuclear Protein Import Complex Disassembly and Importin Recycling. Embo J., 24, 2005
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