PDB: 117 resultsInfo pagesStatus searchChemie searchBIRD

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4ONJ	Crystal structure of the catalytic domain of ntDRM Descriptor: DNA methyltransferase, SINEFUNGIN Authors: Du, J, Patel, D.J. Deposit date: 2014-01-28 Release date: 2014-06-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.807 Å) Cite: Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014
4ONQ	Crystal structure of ntDRM E283S/R309S/F310S/Y590S/D591S mutant Descriptor: DNA methyltransferase, SINEFUNGIN Authors: Du, J, Patel, D.J. Deposit date: 2014-01-28 Release date: 2014-06-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014
1FJX	STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY Descriptor: DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), HHAI DNA METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Vilkaitis, G, Dong, A, Weinhold, E, Cheng, X, Klimasauskas, S. Deposit date: 2000-08-08 Release date: 2000-12-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. J.Biol.Chem., 275, 2000
2QRV	Structure of Dnmt3a-Dnmt3L C-terminal domain complex Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Jia, D, Cheng, X. Deposit date: 2007-07-29 Release date: 2007-12-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
8C59	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C56	CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C57	CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C58	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
2UZ4	HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Leinartaite, L, Grazulis, S. Deposit date: 2007-04-25 Release date: 2008-06-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA Methyltransferase R165N Mutant To be Published
2UYC	HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-03 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2UYH	HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*G*5CMP*GP*CP*TP*GP *AP*C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-06 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.63 Å) Cite: HhaI DNA Methyltransferase S87Q-Q237S Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
3MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY Descriptor: DNA (5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ... Authors: O'Gara, M, Klimasauskas, S, Roberts, R.J, Cheng, X. Deposit date: 1996-07-24 Release date: 1997-01-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J.Mol.Biol., 261, 1996
2C7P	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... Authors: Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7O	HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH Descriptor: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7R	HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH Descriptor: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7Q	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH Descriptor: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes Nucleic Acids Res., 33, 2005
4DKJ	CpG specific methyltransferase in complex with target DNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Bochtler, M. Deposit date: 2012-02-03 Release date: 2012-12-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI. Proc.Natl.Acad.Sci.USA, 110, 2013
4H0N	Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant Descriptor: CALCIUM ION, DNMT2, S-ADENOSYL-L-HOMOCYSTEINE Authors: Li, S, Du, J, Yang, H, Yin, J, Zhong, J, Ding, J. Deposit date: 2012-09-09 Release date: 2012-11-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.712 Å) Cite: Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol, 5, 2013
8TDR	Crystal structure of the methyltransferase domain of DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-04 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain To Be Published
8TE1	Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, L(+)-TARTARIC ACID, ... Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer To Be Published
8TE3	Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K) To Be Published
8TE4	Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer To Be Published
9MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX Descriptor: 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... Authors: O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. Deposit date: 1998-08-07 Release date: 1998-12-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
8T1U	Crystal structure of the DRM2-CTA DNA complex Descriptor: DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Chen, J, Lu, J, Song, J. Deposit date: 2023-06-03 Release date: 2023-11-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.91 Å) Cite: DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2. J.Biol.Chem., 299, 2023
6KDL	Crystal structure of human DNMT3B-DNMT3L complex (I) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.274 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020

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