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4JK2
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BU of 4jk2 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JKR
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BU of 4jkr by Molmil
Crystal Structure of E. coli RNA Polymerase in complex with ppGpp
Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Zuo, Y, Wang, Y, Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4KI2
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BU of 4ki2 by Molmil
Crystallographic analysis of an RNA-polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA
Descriptor: DNA (5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3'), POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2013-05-01
Release date:2013-09-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes.
Acta Crystallogr.,Sect.F, 69, 2013
4KMU
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BU of 4kmu by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN4
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BU of 4kn4 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b
Descriptor: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.965 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN7
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BU of 4kn7 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c
Descriptor: Benzoxazinorifamycin-2c, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.686 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4LJZ
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BU of 4ljz by Molmil
Crystal Structure Analysis of the E.coli holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5871 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LK0
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BU of 4lk0 by Molmil
Crystal Structure Analysis of the E.coli holoenzyme/T7 Gp2 complex
Descriptor: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.9103 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LK1
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BU of 4lk1 by Molmil
Crystal Structure Analysis of the E.coli holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.8369 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LLG
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BU of 4llg by Molmil
Crystal Structure Analysis of the E.coli holoenzyme/Gp2 complex
Descriptor: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-09
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.7936 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4MEX
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BU of 4mex by Molmil
Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H.
Deposit date:2013-08-27
Release date:2014-05-21
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (3.902 Å)
Cite:Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
4MEY
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BU of 4mey by Molmil
Crystal structure of Escherichia coli RNA polymerase holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H.
Deposit date:2013-08-27
Release date:2014-05-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.948 Å)
Cite:Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
4MQ9
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BU of 4mq9 by Molmil
Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077
Descriptor: (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S.
Deposit date:2013-09-16
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIN
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BU of 4oin by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIO
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BU of 4oio by Molmil
Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation
Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIP
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BU of 4oip by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIQ
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BU of 4oiq by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.624 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIR
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BU of 4oir by Molmil
Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4Q4Z
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BU of 4q4z by Molmil
Thermus thermophilus RNA polymerase de novo transcription initiation complex
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ...
Authors:Murakami, K.S.
Deposit date:2014-04-15
Release date:2014-07-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
4Q5S
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BU of 4q5s by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ...
Authors:Murakami, K.S.
Deposit date:2014-04-17
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
4X8K
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BU of 4x8k by Molmil
Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2
Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ...
Authors:Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A.
Deposit date:2014-12-10
Release date:2015-06-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XLN
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BU of 4xln by Molmil
Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA
Descriptor: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XLP
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BU of 4xlp by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter
Descriptor: DNA (25-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XLQ
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BU of 4xlq by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork (-11 base-paired) promoter
Descriptor: DNA (26-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XLR
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Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble promoter and RNA
Descriptor: CarD-like transcriptional regulator, DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015

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