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8GWH
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BU of 8gwh by Molmil
PTPN21 PTP domain C1108S mutant in complex with SRC pTyr530 peptide
Descriptor: SRC pTyr530 peptide, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-17
Release date:2023-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure analysis of PTPN21
To Be Published
8GVV
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BU of 8gvv by Molmil
PTPN21 PTP domain C1108S mutant
Descriptor: IODIDE ION, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure analysis of PTPN21
To Be Published
6PGT
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BU of 6pgt by Molmil
Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-24
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PHA
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BU of 6pha by Molmil
Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, vanadate bound state
Descriptor: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ...
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-25
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PHS
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BU of 6phs by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P185A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-25
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.129 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PFW
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BU of 6pfw by Molmil
Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, apo state
Descriptor: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-22
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
4Y14
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BU of 4y14 by Molmil
Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ...
Authors:Choy, M.S, Connors, C, Page, R, Peti, W.
Deposit date:2015-02-06
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
J.Clin.Invest., 125, 2015
6PG0
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BU of 6pg0 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P188A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-23
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PM8
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BU of 6pm8 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-07-01
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
4YAA
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BU of 4yaa by Molmil
YopH W354Y Yersinia enterocolitica PTPase apo form
Descriptor: ACETATE ION, SULFATE ION, Tyrosine-protein phosphatase YopH
Authors:Moise, G.E, Johnson, S.J, Hengge, A.C.
Deposit date:2015-02-17
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
Biochemistry, 54, 2015
8JBY
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BU of 8jby by Molmil
Vascular endothelial protein tyrosine phosphatase in complex with Cpd-2
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-(hydroxymethyl)-5-(1-methylindol-3-yl)-1,2-oxazole-3-carboxylic acid, ...
Authors:Orita, T, Furuzono, T, Doi, S, Adachi, T.
Deposit date:2023-05-10
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.
Biochemistry, 62, 2023
8JBN
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BU of 8jbn by Molmil
Vascular endothelial protein tyrosine phosphatase in complex with Cpd-1
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-(1~{H}-indol-3-yl)-1,2-oxazole-3-carboxylic acid, ...
Authors:Orita, T, Furuzono, T, Doi, S, Adachi, T.
Deposit date:2023-05-09
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.
Biochemistry, 62, 2023
4ZI4
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BU of 4zi4 by Molmil
YopH W354H Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site
Descriptor: Divanadate Glycerol ester, Tyrosine-protein phosphatase YopH, VANADATE ION
Authors:Moise, G.E, Johnson, S.J, Hengge, A.C.
Deposit date:2015-04-27
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.121 Å)
Cite:Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
Biochemistry, 54, 2015
4Z6B
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BU of 4z6b by Molmil
YopH W354H Yersinia enterocolitica PTPase in the apo form
Descriptor: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase YopH
Authors:Moise, G.E, Johnson, S.J, Hengge, A.C.
Deposit date:2015-04-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
Biochemistry, 54, 2015
4ZN5
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BU of 4zn5 by Molmil
YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site
Descriptor: ACETATE ION, Divanadate Glycerol ester, GLYCEROL, ...
Authors:Moise, G.E, Johnson, S.J, Hengge, A.C.
Deposit date:2015-05-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
Biochemistry, 54, 2015
4ZRT
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BU of 4zrt by Molmil
PTP1BC215S bound to Nephrin peptide substrate
Descriptor: CHLORIDE ION, GLY-PRO-LEU-PTR-ASP-GLU, GLYCEROL, ...
Authors:Selner, N.G, Bell, C.E, Pei, D.
Deposit date:2015-05-12
Release date:2015-06-24
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.
Biochemistry, 53, 2014
5AWX
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BU of 5awx by Molmil
Crystal structure of Human PTPRZ D1 domain
Descriptor: BROMIDE ION, Receptor-type tyrosine-protein phosphatase zeta
Authors:Sugawara, H.
Deposit date:2015-07-10
Release date:2016-02-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma
Sci Rep, 6, 2016
7PPL
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BU of 7ppl by Molmil
SHP2 catalytic domain in complex with IRS1 (625-639) phosphopeptide (pTyr-632, pSer-636)
Descriptor: ETHANOL, GLYCEROL, Insulin receptor substrate 1, ...
Authors:Sok, P, Zeke, A, Remenyi, A.
Deposit date:2021-09-14
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022
7PPM
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BU of 7ppm by Molmil
SHP2 catalytic domain in complex with IRS1 (889-901) phosphopeptide (pSer-892, pTyr-896)
Descriptor: GLYCEROL, Insulin receptor substrate 1, Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11
Authors:Sok, P, Zeke, A, Remenyi, A.
Deposit date:2021-09-14
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022
7PPN
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BU of 7ppn by Molmil
SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195)
Descriptor: GLYCEROL, T-cell-specific surface glycoprotein CD28, Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11
Authors:Sok, P, Zeke, A, Remenyi, A.
Deposit date:2021-09-14
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022
1BZJ
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BU of 1bzj by Molmil
Human ptp1b complexed with tpicooh
Descriptor: 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
Authors:Groves, M.R, Yao, Z.-J, Barford Jr, D.T.B.
Deposit date:1998-10-29
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZH
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BU of 1bzh by Molmil
Cyclic peptide inhibitor of human PTP1B
Descriptor: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B)
Authors:Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D.
Deposit date:1998-10-28
Release date:1999-02-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZC
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BU of 1bzc by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
Authors:Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1C87
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BU of 1c87 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C85
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BU of 1c85 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor: 2-(OXALYL-AMINO)-BENZOIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000

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