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7FB6
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C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1)
Descriptor: CHLORIDE ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
Authors:Baek, Y, Ha, N.-C.
Deposit date:2021-07-08
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
7FB9
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Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Baek, Y, Ha, N.-C.
Deposit date:2021-07-08
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
8GSQ
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Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.
Descriptor: (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
Authors:Aouti, S, Padmanabhan, B.
Deposit date:2022-09-06
Release date:2023-06-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.
Acta Crystallogr D Struct Biol, 79, 2023
8JD8
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Crystal structure of Citrus limon Cu-Zn superoxide dismutase
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Utami, R.A, Yoshida, H, Retnoningrum, D.S, Ismaya, W.T.
Deposit date:2023-05-12
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Direct relationship between dimeric form and activity in the acidic copper-zinc superoxide dismutase from lemon.
Acta Crystallogr.,Sect.F, 79, 2023
8IQ1
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BU of 8iq1 by Molmil
Crystal structure of hydrogen sulfide-bound superoxide dismutase in reduced state
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ...
Authors:Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C.
Deposit date:2023-03-15
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Cell Rep, 42, 2023
8IQ0
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BU of 8iq0 by Molmil
Crystal structure of hydrogen sulfide-bound superoxide dismutase in oxidized state
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ...
Authors:Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C.
Deposit date:2023-03-15
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Cell Rep, 42, 2023
5YTU
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BU of 5ytu by Molmil
Structure of human SOD1 complexed with isoproteranol in C2221 space group
Descriptor: Dihydrogen tetrasulfide, GLYCEROL, ISOPRENALINE, ...
Authors:Manjula, R, Padmanabhan, B.
Deposit date:2017-11-20
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation
FEBS Lett., 592, 2018
5YTO
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BU of 5yto by Molmil
Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound.
Descriptor: 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol, GLYCEROL, PENTASULFIDE-SULFUR, ...
Authors:Padmanabhan, B, Manjula, R.
Deposit date:2017-11-19
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation
FEBS Lett., 592, 2018
5YUL
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Native Structure of hSOD1 in P6322 space group
Descriptor: Dihydrogen tetrasulfide, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
Authors:Manjula, R, Padmanabhan, B.
Deposit date:2017-11-22
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation
FEBS Lett., 592, 2018
6A9O
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BU of 6a9o by Molmil
Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis
Descriptor: 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid, DIMETHYL SULFOXIDE, Dihydrogen tetrasulfide, ...
Authors:Manjula, R, Padmanabhan, B.
Deposit date:2018-07-14
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.
J.Biomol.Struct.Dyn., 37, 2019
8Q6M
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BU of 8q6m by Molmil
Human SOD1 low dose data collecton
Descriptor: ACETATE ION, COPPER (II) ION, SULFATE ION, ...
Authors:Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S.
Deposit date:2023-08-14
Release date:2023-12-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
2GBT
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BU of 2gbt by Molmil
C6A/C111A CuZn Superoxide dismutase
Descriptor: COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M.
Deposit date:2006-03-11
Release date:2007-01-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase
J.Mol.Biol., 365, 2007
2GBU
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BU of 2gbu by Molmil
C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase
Descriptor: Superoxide dismutase [Cu-Zn]
Authors:Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M.
Deposit date:2006-03-11
Release date:2007-01-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase
J.Mol.Biol., 365, 2007
2GBV
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BU of 2gbv by Molmil
C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase
Descriptor: COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M.
Deposit date:2006-03-11
Release date:2007-01-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase
J.Mol.Biol., 365, 2007
2JCW
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BU of 2jcw by Molmil
REDUCED BRIDGE-BROKEN YEAST CU/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE
Descriptor: COPPER (I) ION, CU/ZN SUPEROXIDE DISMUTASE, ZINC ION
Authors:Hart, P.J, Balbirnie, M.M, Ogihara, N.L, Nersissian, A.M, Weiss, M.S, Valentine, J.S, Eisenberg, D.
Deposit date:1998-12-21
Release date:1999-06-08
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structure-based mechanism for copper-zinc superoxide dismutase.
Biochemistry, 38, 1999
2JLP
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BU of 2jlp by Molmil
Crystal structure of human extracellular copper-zinc superoxide dismutase.
Descriptor: COPPER (II) ION, EXTRACELLULAR SUPEROXIDE DISMUTASE (CU-ZN), THIOCYANATE ION, ...
Authors:Antonyuk, S.V, Strange, R.W, Marklund, S.L, Hasnain, S.S.
Deposit date:2008-09-14
Release date:2009-03-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 A Resolution: Insights Into Heparin and Collagen Binding.
J.Mol.Biol., 388, 2009
2K4W
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BU of 2k4w by Molmil
The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica
Descriptor: COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Mori, M, Jimenez, B, Piccioli, M, Battistoni, A, Sette, M, Structural Proteomics in Europe (SPINE)
Deposit date:2008-06-20
Release date:2008-11-18
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica: Structural Insights To Understand the Evolution toward the Dimeric Structure.
Biochemistry, 47, 2008
6SPA
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BU of 6spa by Molmil
A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, SULFATE ION, ...
Authors:Shahid, M, Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S.
Deposit date:2019-08-31
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
Commun Biol, 3, 2020
2LU5
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BU of 2lu5 by Molmil
Structure and chemical shifts of Cu(I),Zn(II) superoxide dismutase by solid-state NMR
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn]
Authors:Knight, M.J, Pell, A.J, Bertini, I, Felli, I.C, Gonnelli, L, Pierattelli, R, Herrmann, T, Emsley, L, Pintacuda, G.
Deposit date:2012-06-08
Release date:2012-06-27
Last modified:2023-06-14
Method:SOLID-STATE NMR
Cite:Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR.
Proc.Natl.Acad.Sci.USA, 109, 2012
4L05
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BU of 4l05 by Molmil
Cu/Zn superoxide dismutase from Brucella abortus
Descriptor: COPPER (I) ION, COPPER (II) ION, GLYCEROL, ...
Authors:Shin, D.S, Didonato, M, Pratt, A.J, Bruns, C.K, Cabelli, D.E, Kroll, J.S, Belzer, C.A, Tabatabai, L.B, Tainer, J.A, Getzoff, E.D.
Deposit date:2013-05-30
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.098 Å)
Cite:Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.
J.Bacteriol., 197, 2015
6SPK
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BU of 6spk by Molmil
A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6
Descriptor: 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Chantadul, V, Amporndanai, K, Wright, G, Shahid, M, Antonyuk, S, Hasnain, S.
Deposit date:2019-09-01
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
Commun Biol, 3, 2020
6SPJ
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BU of 6spj by Molmil
A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1
Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S.
Deposit date:2019-09-01
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
Commun Biol, 3, 2020
6SPH
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BU of 6sph by Molmil
A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, N-phenyl-2-selanylbenzamide, ...
Authors:Shahid, M, Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S.
Deposit date:2019-09-01
Release date:2020-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
Commun Biol, 3, 2020
6SPI
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BU of 6spi by Molmil
A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ...
Authors:Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S.
Deposit date:2019-09-01
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
Commun Biol, 3, 2020
4MCM
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BU of 4mcm by Molmil
Human SOD1 C57S Mutant, As-isolated
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Sea, K, Sohn, S.H, Durazo, A, Sheng, Y, Shaw, B, Cao, X, Taylor, A.B, Whitson, L.J, Holloway, S.P, Hart, P.J, Cabelli, D.E, Gralla, E.B, Valentine, J.S.
Deposit date:2013-08-21
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase.
J.Biol.Chem., 290, 2015

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