6XE9
 
 | | 10S myosin II (smooth muscle) | | Descriptor: | Myosin II heavy chain (smooth muscle), Myosin light chain 9, Myosin light chain smooth muscle isoform | | Authors: | Tiwari, P, Craig, R, Padron, R. | | Deposit date: | 2020-06-12 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Cryo-EM structure of the inhibited (10S) form of myosin II.
Nature, 588, 2020
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6FSA
 | | Beta-Cardiac myosin post-rigor | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, FORMIC ACID, ... | | Authors: | Robert-Paganin, J, Auguin, D, Houdusse, A. | | Deposit date: | 2018-02-19 | | Release date: | 2018-07-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition.
Nat Commun, 9, 2018
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2JHR
 | | Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate and pentabromopseudilin | | Descriptor: | ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN, ... | | Authors: | Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. | | Deposit date: | 2008-03-25 | | Release date: | 2009-01-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity.
Nat.Struct.Mol.Biol., 16, 2009
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2JJ9
 | | Crystal structure of myosin-2 in complex with ADP-metavanadate | | Descriptor: | ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN | | Authors: | Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. | | Deposit date: | 2008-03-25 | | Release date: | 2009-01-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity.
Nat.Struct.Mol.Biol., 16, 2009
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8U95
 | | The structure of myosin heavy chain from Drosophila melanogaster flight muscle thick filaments | | Descriptor: | Myosin heavy chain, isoform U | | Authors: | Abbasi Yeganeh, F, Rastegarpouyani, H, Li, J, Taylor, K.A. | | Deposit date: | 2023-09-18 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structure of the Drosophila melanogaster Flight Muscle Myosin Filament at 4.7 angstrom Resolution Reveals New Details of Non-Myosin Proteins.
Int J Mol Sci, 24, 2023
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8W41
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5T45
 | | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form | | Descriptor: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A. | | Deposit date: | 2016-08-29 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5TBY
 | | HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240) | | Descriptor: | Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... | | Authors: | ALAMO, L, WARE, J.S, PINTO, A, GILLILAN, R.E, SEIDMAN, J.G, SEIDMAN, C.E, PADRON, R. | | Deposit date: | 2016-09-13 | | Release date: | 2017-06-07 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (20 Å) | | Cite: | Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.
Elife, 6, 2017
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2MYS
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5M05
 | | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form | | Descriptor: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sirigu, S, Hartman, J, Houdusse, A. | | Deposit date: | 2016-10-03 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.675 Å) | | Cite: | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7YV9
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5V7X
 | | Crystal Structure of Myosin 1b residues 1-728 with bound sulfate and Calmodulin | | Descriptor: | Calmodulin-1, SULFATE ION, Unconventional myosin-Ib | | Authors: | Zwolak, A, Shuman, H, Dominguez, R, Ostap, E.M. | | Deposit date: | 2017-03-20 | | Release date: | 2018-02-28 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.141 Å) | | Cite: | High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7KOG
 | | Lethocerus Myosin II complete coiled-coil domain resolved in its native environment | | Descriptor: | Myosin heavy chain isoform Mhc_X1 | | Authors: | Rahmani, H, Hu, Z, Daneshparvar, N, Taylor, D, Taylor, K.A. | | Deposit date: | 2020-11-09 | | Release date: | 2021-03-24 | | Last modified: | 2021-04-14 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | The myosin II coiled-coil domain atomic structure in its native environment.
Proc.Natl.Acad.Sci.USA, 118, 2021
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5N69
 | | Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil | | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | | Deposit date: | 2017-02-14 | | Release date: | 2017-08-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
Nat Commun, 8, 2017
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2OS8
 | | Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor | | Descriptor: | CALCIUM ION, MAGNESIUM ION, Myosin essential light chain, ... | | Authors: | Yang, Y, Gourinath, S, Cohen, C, Brown, J.H. | | Deposit date: | 2007-02-05 | | Release date: | 2007-05-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.27 Å) | | Cite: | Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor.
Structure, 15, 2007
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2OTG
 | | Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | | Authors: | Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. | | Deposit date: | 2007-02-08 | | Release date: | 2007-05-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor.
Structure, 15, 2007
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5N6A
 | | Cardiac muscle myosin motor domain in the pre-powerstroke state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | | Deposit date: | 2017-02-14 | | Release date: | 2017-08-09 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
Nat Commun, 8, 2017
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8ACT
 | | structure of the human beta-cardiac myosin folded-back off state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light chain 3, ... | | Authors: | Grinzato, A, Kandiah, E, Robert-Paganin, J, Auguin, D, Kikuti, C, Nandwani, N, Moussaoui, D, Pathak, D, Ruppel, K.M, Spudich, J.A, Houdusse, A. | | Deposit date: | 2022-07-06 | | Release date: | 2023-06-07 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the folded-back state of human beta-cardiac myosin.
Nat Commun, 14, 2023
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8A12
 | | Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Moussaoui, D, Robblee, J.P, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Mueller-Dieckmann, C, Baum, J, Robert-Paganin, J, Trybus, K.M, Houdusse, A. | | Deposit date: | 2022-05-31 | | Release date: | 2023-06-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.
Nat Commun, 14, 2023
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7B1A
 | | Myosin-II-AA mutant motor domain | | Descriptor: | 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ... | | Authors: | Ewert, W, Preller, M. | | Deposit date: | 2020-11-24 | | Release date: | 2021-01-13 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
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7B19
 | | Mutant Myosin-II-GGG motor domain | | Descriptor: | ADP METAVANADATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Ewert, W, Preller, M. | | Deposit date: | 2020-11-24 | | Release date: | 2021-01-13 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
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3BZ9
 | | Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | | Descriptor: | (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Allingham, J.S, Rayment, I. | | Deposit date: | 2008-01-17 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
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3BZ8
 | | Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | | Descriptor: | (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Allingham, J.S, Rayment, I. | | Deposit date: | 2008-01-17 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
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3BZ7
 | | Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | | Descriptor: | (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Allingham, J.S, Rayment, I. | | Deposit date: | 2008-01-17 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
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7DHW
 | | Crystal structure of myosin-XI motor domain in complex with ADP-ALF4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Suzuki, K, Haraguchi, T, Tamanaha, M, Yoshimura, K, Imi, T, Tominaga, M, Sakayama, H, Nishiyama, T, Ito, K, Murata, T. | | Deposit date: | 2020-11-17 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Discovery of ultrafast myosin, its amino acid sequence, and structural features.
Proc.Natl.Acad.Sci.USA, 119, 2022
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