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2PBI
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BU of 2pbi by Molmil
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure
Descriptor: GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9
Authors:Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
2OVR
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BU of 2ovr by Molmil
Structure of the Skp1-Fbw7-CyclinEdegN complex
Descriptor: F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ...
Authors:Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P.
Deposit date:2007-02-14
Release date:2007-04-24
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
Mol.Cell, 26, 2007
2PM7
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BU of 2pm7 by Molmil
Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version
Descriptor: Protein transport protein SEC13, Protein transport protein SEC31
Authors:Goldberg, J, Fath, S, Mancias, J.D, Bi, X.
Deposit date:2007-04-20
Release date:2007-07-03
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure and Organization of Coat Proteins in the COPII Cage.
Cell(Cambridge,Mass.), 129, 2007
2PM6
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BU of 2pm6 by Molmil
Crystal Structure of yeast Sec13/31 edge element of the COPII vesicular coat, native version
Descriptor: Protein transport protein SEC13, Protein transport protein SEC31
Authors:Goldberg, J, Fath, S, Mancias, J.D, Bi, X.
Deposit date:2007-04-20
Release date:2007-07-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure and Organization of Coat Proteins in the COPII Cage.
Cell(Cambridge,Mass.), 129, 2007
2QXV
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BU of 2qxv by Molmil
Structural basis of EZH2 recognition by EED
Descriptor: Embryonic ectoderm development, Enhancer of zeste homolog 2
Authors:Han, Z.
Deposit date:2007-08-13
Release date:2007-08-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural basis of EZH2 recognition by EED
Structure, 15, 2007
2TRC
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BU of 2trc by Molmil
PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
Descriptor: GADOLINIUM ATOM, PHOSDUCIN, TRANSDUCIN
Authors:Gaudet, R, Bohm, A, Sigler, P.B.
Deposit date:1997-01-06
Release date:1997-06-05
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin.
Cell(Cambridge,Mass.), 87, 1996
3SFZ
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BU of 3sfz by Molmil
Crystal structure of full-length murine Apaf-1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Apoptotic peptidase activating factor 1, GAMMA-BUTYROLACTONE
Authors:Eschenburg, S, Reubold, T.F.
Deposit date:2011-06-14
Release date:2011-08-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Structure, 19, 2011
3SHF
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BU of 3shf by Molmil
Crystal structure of the R265S mutant of full-length murine Apaf-1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Apoptotic peptidase activating factor 1, GAMMA-BUTYROLACTONE
Authors:Eschenburg, S, Reubold, T.F.
Deposit date:2011-06-16
Release date:2011-08-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Structure, 19, 2011
3V7D
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BU of 3v7d by Molmil
Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
Descriptor: Cell division control protein 4, Protein SIC1, Suppressor of kinetochore protein 1
Authors:Tang, X, Orlicky, S, Mittag, T, Csizmok, V, Pawson, T, Forman-Kay, J, Sicheri, F, Tyers, M.
Deposit date:2011-12-20
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 109, 2012
3W15
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BU of 3w15 by Molmil
Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p
Descriptor: 3-ketoacyl-CoA thiolase, peroxisomal, Maltose-binding periplasmic protein, ...
Authors:Pan, D, Nakatsu, T, Kato, H.
Deposit date:2012-11-06
Release date:2013-07-03
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p
Nat.Struct.Mol.Biol., 20, 2013
4KFM
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BU of 4kfm by Molmil
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
Descriptor: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Whorton, M.R, MacKinnon, R.
Deposit date:2013-04-27
Release date:2013-06-12
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:X-ray structure of the mammalian GIRK2-beta gamma G-protein complex.
Nature, 498, 2013
4L9O
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BU of 4l9o by Molmil
Crystal Structure of the Sec13-Sec16 blade-inserted complex from Pichia pastoris
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:McMahon, C, Jeffrey, P.D, Hughson, F.M.
Deposit date:2013-06-18
Release date:2013-10-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Sec16 influences transitional ER sites by regulating rather than organizing COPII.
Mol Biol Cell, 24, 2013
4N14
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BU of 4n14 by Molmil
Crystal structure of Cdc20 and apcin complex
Descriptor: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate, Cell division cycle protein 20 homolog
Authors:Luo, X, Tian, W, Yu, H.
Deposit date:2013-10-03
Release date:2014-08-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Nature, 514, 2014
4OZU
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BU of 4ozu by Molmil
Crystal Structure of WD40 domain from Toxoplasma gondii coronin
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Coronin
Authors:Kallio, J.P, Kursula, I.
Deposit date:2014-02-19
Release date:2014-08-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.
Faseb J., 28, 2014
4OWR
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BU of 4owr by Molmil
Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair Rae1-Nup98
Descriptor: Matrix protein, Nuclear pore complex protein Nup98-Nup96, mRNA export factor
Authors:Ren, Y, Quan, B, Seo, H.S, Blobel, G.
Deposit date:2014-02-03
Release date:2014-06-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 Nup98).
Proc.Natl.Acad.Sci.USA, 111, 2014
4PBZ
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BU of 4pbz by Molmil
Structure of the human RbAp48-MTA1(670-695) complex
Descriptor: Histone-binding protein RBBP4, Metastasis-associated protein MTA1
Authors:Murthy, A, Pei, X.Y, Watson, A.A, Silva, A.P.G, Mackay, J.P, Laue, E.D.
Deposit date:2014-04-14
Release date:2014-06-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.
J.Biol.Chem., 289, 2014
4PSX
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BU of 4psx by Molmil
Crystal structure of histone acetyltransferase complex
Descriptor: COENZYME A, Histone H3, Histone H4, ...
Authors:Yang, M, Li, Y.
Deposit date:2014-03-08
Release date:2014-07-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.509 Å)
Cite:Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex
Genes Dev., 28, 2014
4PBY
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BU of 4pby by Molmil
Structure of the human RbAp48-MTA1(656-686) complex
Descriptor: Histone-binding protein RBBP4, ISOPROPYL ALCOHOL, Metastasis-associated protein MTA1
Authors:Murthy, A, Lejon, S, Alqarni, S.S.M, Silva, A.P.G, Watson, A.A, Mackay, J.P, Laue, E.D.
Deposit date:2014-04-14
Release date:2014-06-11
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.
J.Biol.Chem., 289, 2014
4PC0
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BU of 4pc0 by Molmil
Structure of the human RbAp48-MTA1(670-711) complex
Descriptor: CALCIUM ION, GLYCEROL, Histone-binding protein RBBP4, ...
Authors:Alqarni, S.S.M, Silva, A.P.G, Mackay, J.P, Laue, E.D.
Deposit date:2014-04-14
Release date:2014-06-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.
J.Biol.Chem., 289, 2014
4PSW
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BU of 4psw by Molmil
Crystal structure of histone acetyltransferase complex
Descriptor: COENZYME A, Histone H4 type VIII, Histone acetyltransferase type B catalytic subunit, ...
Authors:Yang, M, Li, Y.
Deposit date:2014-03-08
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex
Genes Dev., 28, 2014
7ZU0
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BU of 7zu0 by Molmil
HOPS tethering complex from yeast
Descriptor: E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ...
Authors:Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C.
Deposit date:2022-05-11
Release date:2022-09-28
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
7ZUP
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BU of 7zup by Molmil
Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound
Descriptor: 3-ethylimidazo[4,5-b]pyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-12
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZVU
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BU of 7zvu by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-17
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZUU
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BU of 7zuu by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-13
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZV2
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BU of 7zv2 by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-13
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022

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