6DS0
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, CHOLESTEROL, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6G79
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COUPLING SPECIFICITY OF HETEROTRIMERIC GO TO THE SEROTONIN 5-HT1B RECEPTOR
Descriptor:Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(o) subunit alpha, ...
Authors:Garcia-Nafria, J., Nehme, R., Edwards, P., Tate, C.G.
Deposit date:2018-04-05
Release date:2018-06-20
Last modified:2018-09-19
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Cryo-EM structure of the serotonin 5-HT1Breceptor coupled to heterotrimeric Go.
Nature, 558, 2018
6GDG
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CRYO-EM STRUCTURE OF THE ADENOSINE A2A RECEPTOR BOUND TO A MINIGS HETEROTRIMER
Descriptor:TrxA,Adenosine receptor A2a, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Garcia-Nafria, J., Lee, Y.
Deposit date:2018-04-23
Release date:2018-05-16
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Cryo-EM structure of the adenosine A2Areceptor coupled to an engineered heterotrimeric G protein.
Elife, 7, 2018
6GPS
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CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Descriptor:C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium
Authors:Pautsch, A., Schnapp, G.
Deposit date:2018-06-07
Release date:2019-01-02
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Structure, 2018
6GPX
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CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Descriptor:C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, OLEIC ACID, ...
Authors:Pautsch, A., Schnapp, G., Cheng, R., Apel, A.
Deposit date:2018-06-07
Release date:2019-01-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Structure, 2018
6IGK
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH ENDOTHELIN-3
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, Endothelin-3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., Kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IGL
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH IRL1620
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, IRL1620, CITRIC ACID, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IIU
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO RAMATROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IIV
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO DALTROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6M9T
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CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
Descriptor:Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, ...
Authors:Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
Deposit date:2018-08-24
Release date:2018-12-05
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
Nat. Chem. Biol., 15, 2019
6MET
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-07
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6MXT
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CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
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