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6EQ3
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MTH1 in complex with fragment 9
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [2-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-4-yl]methanol
Authors:Wiedmer, L, Sledz, P, Caflisch, A.
Deposit date:2017-10-12
Release date:2018-10-31
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6EQ5
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MTH1 in complex with fragment 4
Descriptor: 1H-benzimidazol-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
Authors:Wiedmer, L, Sledz, P, Caflisch, A.
Deposit date:2017-10-12
Release date:2018-10-31
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6YPF
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BU of 6ypf by Molmil
NUDIX1 hydrolase from Rosa x hybrida in complex with geranyl pyrophosphate
Descriptor: GERANYL DIPHOSPHATE, Geranyl diphosphate phosphohydrolase
Authors:Degut, C, Rety, S, Tisne, C, Baudino, S.
Deposit date:2020-04-16
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Functional diversification in the Nudix hydrolase gene family drives sesquiterpene biosynthesis in Rosa × wichurana.
Plant J., 104, 2020
6F22
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BU of 6f22 by Molmil
Complex between MTH1 and compound 29 (a 4-amino-2,7-diazaindole derivative)
Descriptor: (3~{S})-3-phenyl-4-(2~{H}-pyrazolo[3,4-b]pyridin-4-yl)morpholine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
Authors:Viklund, J, Talagas, A, Tresaugues, L, Andersson, M, Ericsson, U, Forsblom, R, Ginman, T, Hallberg, K, Lindstrom, J, Persson, L, Silvander, C, Rahm, F.
Deposit date:2017-11-23
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J. Med. Chem., 61, 2018
6F1X
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Complex between MTH1 and compound 7 (a 7-azaindole-2-amide derivative)
Descriptor: 4-(3-chlorophenyl)-~{N}-ethyl-1~{H}-pyrrolo[2,3-b]pyridine-2-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
Authors:Viklund, J, Talagas, A, Tresaugues, L, Andersson, M, Ericsson, U, Forsblom, R, Ginman, T, Hallberg, K, Lindstrom, J, Persson, L, Silvander, C, Rahm, F.
Deposit date:2017-11-23
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J. Med. Chem., 61, 2018
6F23
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BU of 6f23 by Molmil
Complex between MTH1 and compound 16 (a 4-amino-7-azaindole derivative)
Descriptor: 4-[(2~{R})-2-phenylpyrrolidin-1-yl]-1~{H}-pyrrolo[2,3-b]pyridine, 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, ...
Authors:Viklund, J, Tresaugues, L, Talagas, A, Andersson, M, Ericsson, U, Forsblom, R, Ginman, T, Hallberg, K, Lindstrom, J, Persson, L, Silvander, C, Rahm, F.
Deposit date:2017-11-23
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J. Med. Chem., 61, 2018
6F20
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Complex between MTH1 and compound 1 (a 7-azaindole-4-ester derivative)
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, Ethyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate, ...
Authors:Viklund, J, Talagas, A, Tresaugues, L, Andersson, M, Ericsson, U, Forsblom, R, Ginman, T, Hallberg, K, Lindstrom, J, Persson, L, Silvander, C, Rahm, F.
Deposit date:2017-11-23
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J. Med. Chem., 61, 2018
6FL4
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BU of 6fl4 by Molmil
A. thaliana NUDT1 in complex with 8-oxo-dGTP
Descriptor: 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Nudix hydrolase 1
Authors:Jemth, A.S, Scaletti-Hutchinson, E, Carter, M, Helleday, T, Stenmark, P.
Deposit date:2018-01-25
Release date:2019-02-06
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Biochemistry, 58, 2019
5ANW
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BU of 5anw by Molmil
MTH1 in complex with compound 24
Descriptor: 2-[4-(2-AMINOQUINAZOLIN-4-YL)PHENYL]-N,N-DIMETHYL-ACETAMIDE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE
Authors:Read, J.A, Breed, J.
Deposit date:2015-09-08
Release date:2016-03-02
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5ANT
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BU of 5ant by Molmil
Potent and selective inhibitors of MTH1 probe its role in cancer cell survival
Descriptor: 2-(2-methoxyethoxy)-6-(methylamino)-9-(phenylmethyl)-7H-purin-8-one, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE
Authors:Kettle, J.G, Alwan, H, Bista, M, Breed, J, Kack, H, Eckersley, K, Foote, K.M, Fillery, S, Goodwin, L, Jones, D, Lau, A, Nissink, J.W.M, Read, J, Scott, J, Taylor, B, Walker, G, Wissler, L.
Deposit date:2015-09-08
Release date:2016-03-02
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5BON
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BU of 5bon by Molmil
Crystal structure of human Nudt15 (MTH2)
Descriptor: MAGNESIUM ION, Probable 8-oxo-dGTP diphosphatase NUDT15
Authors:Carter, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2015-05-27
Release date:2015-08-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Nat Commun, 6, 2015
5ANU
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BU of 5anu by Molmil
MTH1 in complex with compound 15
Descriptor: 13-(METHYLAMINO)-23,24,25-TRIOXA-17,18,19,21-TETRAZATETRACYCLO-TRICOSA-1(3),2(10),4(11),12(14),13(18),16(19)-HEXAN-15-ONE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, DIMETHYL SULFOXIDE
Authors:Read, J.A, Breed, J.
Deposit date:2015-09-08
Release date:2016-03-02
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5ANS
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BU of 5ans by Molmil
Potent and selective inhibitors of MTH1 probe its role in cancer cell survival
Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE
Authors:Kettle, J.G, Alwan, H, Bista, M, Breed, J, Kack, H, Eckersley, K, Foote, K.M, Fillery, S, Goodwin, L, Jones, D, Lau, A, Nissink, J.W.M, Read, J, Scott, J, Taylor, B, Walker, G, Wissler, L.
Deposit date:2015-09-08
Release date:2016-03-02
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5ANV
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BU of 5anv by Molmil
MTH1 in complex with compound 15
Descriptor: 4-(4-CHLORO-2-FLUORO-ANILINO)-6,7-DIMETHOXY-N-METHYL-QUINOLINE-3-CARBOXAMIDE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE
Authors:Read, J.A, Breed, J.
Deposit date:2015-09-08
Release date:2016-03-02
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5C8L
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BU of 5c8l by Molmil
Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, NudF protein, ...
Authors:Gabelli, S.B, de la Pena, A.H, Suarez, A, Amzel, L.M.
Deposit date:2015-06-25
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
5C7Q
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Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Gabelli, S.B, de la Pena, A.H, Suarez, A, Amzel, L.M.
Deposit date:2015-06-24
Release date:2016-01-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
5CFJ
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Structural and functional attributes of malaria parasite Ap4A hydrolase
Descriptor: BIS(5'-nucleosyl)-tetraphosphatase (Diadenosine tetraphosphatase), putative, DI(HYDROXYETHYL)ETHER, ...
Authors:Sharma, A, Yogavel, M, Sharma, A.
Deposit date:2015-07-08
Release date:2016-02-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase
Sci Rep, 6, 2016
5C7T
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Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase in complex with ADP-ribose
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5-DIPHOSPHORIBOSE, DI(HYDROXYETHYL)ETHER, ...
Authors:Gabelli, S.B, de la Pena, A.H, Suarez, A, Amzel, L.M.
Deposit date:2015-06-24
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
5CFI
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Structural and functional attributes of malaria parasite Ap4A hydrolase
Descriptor: BIS(5'-nucleosyl)-tetraphosphatase (Diadenosine tetraphosphatase), putative
Authors:Sharma, A, Yogavel, M, Sharma, A.
Deposit date:2015-07-08
Release date:2016-02-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase
Sci Rep, 6, 2016
5FSK
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MTH1 substrate recognition: Complex with 8-oxo-dGTP.
Descriptor: 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 8-OXO-ADENOSINE-5'-TRIPHOSPHATE, ACETATE ION
Authors:Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J.
Deposit date:2016-01-06
Release date:2016-07-20
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Mth1 Substrate Recognition--an Example of Specific Promiscuity.
Plos One, 11, 2016
5FSI
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MTH1 substrate recognition: Complex with 8-oxo-dGTP.
Descriptor: 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
Authors:Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J.
Deposit date:2016-01-06
Release date:2016-07-11
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Mth1 Substrate Recognition--an Example of Specific Promiscuity.
Plos One, 11, 2016
5FSM
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MTH1 substrate recognition: Complex with a methylbenzimidazolyl acetamide.
Descriptor: 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, DIMETHYL SULFOXIDE, ...
Authors:Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J.
Deposit date:2016-01-06
Release date:2016-07-20
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Mth1 Substrate Recognition--an Example of Specific Promiscuity.
Plos One, 11, 2016
5FSN
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MTH1 substrate recognition: Complex with a aminomethylpyrimidinyl oxypropanol.
Descriptor: 3-(2-AMINO-6-METHYL-PYRIMIDIN-4-YL)OXYPROPAN-1-OL, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, ...
Authors:Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J.
Deposit date:2016-01-06
Release date:2016-07-20
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Mth1 Substrate Recognition--an Example of Specific Promiscuity.
Plos One, 11, 2016
5FSL
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MTH1 substrate recognition: Complex with a methylaminopurinone
Descriptor: 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 9-METHYL-2-(METHYLAMINO)-1H-PURIN-6-ONE, SULFATE ION
Authors:Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J.
Deposit date:2016-01-06
Release date:2016-07-20
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Mth1 Substrate Recognition--an Example of Specific Promiscuity.
Plos One, 11, 2016
5FSO
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MTH1 substrate recognition: Complex with a methylaminopyrimidinedione.
Descriptor: 6-(METHYLAMINO)-1H-PYRIMIDINE-2,4-DIONE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, ...
Authors:Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J.
Deposit date:2016-01-06
Release date:2017-01-18
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:MTH1 Substrate Recognition--An Example of Specific Promiscuity.
PLoS ONE, 11, 2016

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