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7A5G
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BU of 7a5g by Molmil
Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA
Descriptor: 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ...
Authors:Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V.
Deposit date:2020-08-21
Release date:2020-12-23
Method:ELECTRON MICROSCOPY (4.33 Å)
Cite:Elongational stalling activates mitoribosome-associated quality control.
Science, 370, 2020
6ZP4
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BU of 6zp4 by Molmil
SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2020-07-08
Release date:2020-07-29
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
7ABF
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BU of 7abf by Molmil
Human pre-Bact-1 spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-09
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7A5K
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BU of 7a5k by Molmil
Structure of the human mitoribosome in the post translocation state bound to mtEF-G1
Descriptor: 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ...
Authors:Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V.
Deposit date:2020-08-21
Release date:2020-12-23
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Elongational stalling activates mitoribosome-associated quality control.
Science, 370, 2020
7ABG
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BU of 7abg by Molmil
Human pre-Bact-1 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-23
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7ABI
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BU of 7abi by Molmil
Human pre-Bact-2 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2021-02-10
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
3ZZU
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BU of 3zzu by Molmil
Crystal structure of Staphylococcus aureus elongation factor G with mutations M16I and F88L
Descriptor: ELONGATION FACTOR G
Authors:Koripella, R.K, Chen, Y, Selmer, M, Sanyal, S.
Deposit date:2011-09-05
Release date:2012-07-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Mechanism of Elongation Factor-G Mediated Fusidic Acid Resistance and Fitness Compensation in Staphylococcus Aureus.
J.Biol.Chem., 287, 2012
4ACA
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BU of 4aca by Molmil
CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS, APO FORM
Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N.
Deposit date:2011-12-14
Release date:2012-11-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
4ACB
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BU of 4acb by Molmil
CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH THE GTP ANALOGUE GPPNHP
Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N.
Deposit date:2011-12-14
Release date:2012-11-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
7ABZ
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BU of 7abz by Molmil
Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R.
Deposit date:2020-09-09
Release date:2021-08-18
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structures of tmRNA and SmpB as they transit through the ribosome.
Nat Commun, 12, 2021
4B3X
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BU of 4b3x by Molmil
Bacterial translation initiation factor IF2 (1-363), apo form
Descriptor: GLYCEROL, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-26
Release date:2013-05-29
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4B43
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BU of 4b43 by Molmil
Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A
Descriptor: GLYCEROL, IODIDE ION, MAGNESIUM ION, ...
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B44
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BU of 4b44 by Molmil
Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH8.0
Descriptor: GUANOSINE-5'-DIPHOSPHATE, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B47
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BU of 4b47 by Molmil
Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH6.5
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
7ASE
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BU of 7ase by Molmil
43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase
Descriptor: 18S, 40S ribosomal protein S10, putative, ...
Authors:Bochler, A, Brito Querido, J, Prilepskaja, T, Soufari, H, Del Cistia, M.L, Kuhn, L, Rimoldi Ribeiro, A, Valasek, L.S, Hashem, Y.
Deposit date:2020-10-27
Release date:2021-04-14
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Cell Rep, 33, 2020
4B48
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BU of 4b48 by Molmil
Bacterial translation initiation factor IF2 (1-363), complex with GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4C0S
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BU of 4c0s by Molmil
Mammalian translation elongation factor eEF1A2
Descriptor: ELONGATION FACTOR 1-ALPHA 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Crepin, T, Shalak, V.F, Yaremchuk, A.D, Vlasenko, D.O, McCarthy, A.A, Negrutskii, B.S, Tukalo, M.A, El'skaya, A.V.
Deposit date:2013-08-07
Release date:2014-08-27
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Mammalian Translation Elongation Factor Eef1A2: X-Ray Structure and New Features of Gdp/GTP Exchange Mechanism in Higher Eukaryotes
Nucleic Acids Res., 42, 2014
7B9V
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BU of 7b9v by Molmil
Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound
Descriptor: 5' exon of UBC4 mRNA, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0054360.mRNA.1.CDS.1, ...
Authors:Wilkinson, M.E, Fica, S.M, Galej, W.P, Nagai, K.
Deposit date:2020-12-14
Release date:2021-03-10
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for conformational equilibrium of the catalytic spliceosome.
Mol.Cell, 81, 2021
4CXH
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BU of 4cxh by Molmil
Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement
Descriptor: 18S RRNA - H44, 18S RRNA - H5-H14, 18S RRNA - H8, ...
Authors:Budkevich, T.V, Giesebrecht, J, Behrmann, E, Loerke, J, Ramrath, D.J.F, Mielke, T, Ismer, J, Hildebrand, P, Tung, C.-S, Nierhaus, K.H, Sanbonmatsu, K.Y, Spahn, C.M.T.
Deposit date:2014-04-07
Release date:2014-07-16
Last modified:2019-06-26
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement.
Cell(Cambridge,Mass.), 158, 2014
4CRN
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BU of 4crn by Molmil
Cryo-EM of a pretermination complex with eRF1 and eRF3
Descriptor: ERF1 IN RIBOSOME-BOUND ERF1-ERF3-GDPNP COMPLEX, ERF3 IN RIBOSOME BOUND ERF1-ERF3-GDPNP COMPLEX, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Preis, A, Heuer, A, Barrio-Garcia, C, Hauser, A, Eyler, D, Berninghausen, O, Green, R, Becker, T, Beckmann, R.
Deposit date:2014-02-28
Release date:2014-07-23
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing Erf1-Erf3 or Erf1-Abce1.
Cell Rep., 8, 2014
4CXG
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BU of 4cxg by Molmil
Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement
Descriptor: 18S RRNA - H44, 18S RRNA - H5-H14, 18S RRNA - H8, ...
Authors:Budkevich, T.V, Giesebrecht, J, Behrmann, E, Loerke, J, Ramrath, D.J.F, Mielke, T, Ismer, J, Hildebrand, P, Tung, C.-S, Nierhaus, K.H, Sanbonmatsu, K.Y, Spahn, C.M.T.
Deposit date:2014-04-07
Release date:2014-07-16
Last modified:2019-06-26
Method:ELECTRON MICROSCOPY (8.7 Å)
Cite:Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement.
Cell(Cambridge,Mass.), 158, 2014
4D61
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BU of 4d61 by Molmil
Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state
Descriptor: 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ...
Authors:Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T.
Deposit date:2014-11-07
Release date:2015-03-04
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires.
Mol.Cell, 57, 2015
3SJZ
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BU of 3sjz by Molmil
The structure of aIF2gamma subunit delta 41-45 from archaeon Sulfolobus solfataricus complexed with GDP and GDPNP
Descriptor: BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Arkhipova, V.I, Lazopulo, S.M, Lazopulo, A.M, Nikonov, O.S, Stolboushkina, E.A, Gabdoulkhakov, A.G, Garber, M.B, Nikonov, S.V.
Deposit date:2011-06-22
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:HOLD FOR PUBLICATION
To be Published
3U6K
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BU of 3u6k by Molmil
Ef-tu (escherichia coli) in complex with nvp-ldk733
Descriptor: Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Palestrant, D.J.
Deposit date:2011-10-12
Release date:2012-02-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
J.Med.Chem., 54, 2011
3U2Q
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BU of 3u2q by Molmil
EF-Tu (Escherichia coli) in complex with NVP-LFF571
Descriptor: Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Palestrant, D.J.
Deposit date:2011-10-04
Release date:2012-05-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of LFF571: an investigational agent for Clostridium difficile infection.
J.Med.Chem., 55, 2012

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