Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3QAK
DownloadVisualize
BU of 3qak by Molmil
Agonist bound structure of the human adenosine A2a receptor
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,lysozyme chimera
Authors:Xu, F, Wu, H, Katritch, V, Han, G.W, Cherezov, V, Stevens, R, GPCR Network (GPCR)
Deposit date:2011-01-11
Release date:2011-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure of an agonist-bound human A2A adenosine receptor.
Science, 332, 2011
8U4N
DownloadVisualize
BU of 8u4n by Molmil
Structure of Apo CXCR4/Gi complex
Descriptor: C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Saotome, K, McGoldrick, L.L, Franklin, M.C.
Deposit date:2023-09-11
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
6ZA8
DownloadVisualize
BU of 6za8 by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a
Descriptor: (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-06-05
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
7UM5
DownloadVisualize
BU of 7um5 by Molmil
CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT
Descriptor: 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, S, Fay, J.F, Roth, B.L.
Deposit date:2022-04-06
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29, 2022
8INR
DownloadVisualize
BU of 8inr by Molmil
Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ...
Authors:Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W.
Deposit date:2023-03-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Cell Discov, 9, 2023
6RZ9
DownloadVisualize
BU of 6rz9 by Molmil
Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dih ydro-1,4-benzoxazine-2-carboxylic acid, CHOLESTEROL, ...
Authors:Gusach, A, Luginina, A, Marin, E, Brouillette, R.L, Besserer-Offroy, E, Longpre, J.M, Ishchenko, A, Popov, P, Fujimoto, T, Maruyama, T, Stauch, B, Ergasheva, M, Romanovskaya, D, Stepko, A, Kovalev, K, Shevtsov, M, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Mishin, A, Cherezov, V.
Deposit date:2019-06-12
Release date:2019-12-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
Nat Commun, 10, 2019
6D27
DownloadVisualize
BU of 6d27 by Molmil
Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, OLEIC ACID, ...
Authors:Wang, L, Yao, D, Deepak, K, Liu, H, Gong, W, Fan, H, Wei, Z, Zhang, C.
Deposit date:2018-04-13
Release date:2018-10-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.738 Å)
Cite:Structures of the Human PGD2Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Mol. Cell, 72, 2018
8SMV
DownloadVisualize
BU of 8smv by Molmil
GPR161 Gs heterotrimer
Descriptor: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hoppe, N, Manglik, A, Harrison, S.
Deposit date:2023-04-26
Release date:2024-02-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Biorxiv, 2023
6TPJ
DownloadVisualize
BU of 6tpj by Molmil
Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution
Descriptor: AMMONIUM ION, OLEIC ACID, Orexin receptor type 2,GlgA glycogen synthase,Hypocretin receptor-2, ...
Authors:Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A.
Deposit date:2019-12-13
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J.Med.Chem., 63, 2020
6TPG
DownloadVisualize
BU of 6tpg by Molmil
Crystal structure of the Orexin-2 receptor in complex with EMPA at 2.74 A resolution
Descriptor: N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, Orexin receptor type 2,GlgA glycogen synthase,Hypocretin receptor-2, ...
Authors:Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A.
Deposit date:2019-12-13
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.741 Å)
Cite:Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J.Med.Chem., 63, 2020
7UM7
DownloadVisualize
BU of 7um7 by Molmil
CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine
Descriptor: (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, S, Fay, J.F, Roth, B.L.
Deposit date:2022-04-06
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29, 2022
4BUO
DownloadVisualize
BU of 4buo by Molmil
High Resolution Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
Descriptor: GLYCINE, NEUROTENSIN RECEPTOR TYPE 1, NEUROTENSIN/NEUROMEDIN N
Authors:Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A.
Deposit date:2013-06-21
Release date:2014-01-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
6W25
DownloadVisualize
BU of 6w25 by Molmil
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119
Descriptor: CALCIUM ION, Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4, OLEIC ACID, ...
Authors:Yu, J, Gimenez, L.E, Hernandez, C.C, Wu, Y, Wein, A.H, Han, G.W, McClary, K, Mittal, S.R, Burdsall, K, Stauch, B, Wu, L, Stevens, S.N, Peisley, A, Williams, S.Y, Chen, V, Millhauser, G.L, Zhao, S, Cone, R.D, Stevens, R.C.
Deposit date:2020-03-04
Release date:2020-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.
Science, 368, 2020
7YK7
DownloadVisualize
BU of 7yk7 by Molmil
Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ...
Authors:Chen, Y, Zhou, Q.T, Wang, J, Xu, Y.W, Wang, Y, Yan, J.H, Wang, Y.B, Zhu, Q, Zhao, F.H, Li, C.H, Chen, C.W, Cai, X.Q, Bathgate, R.A.D, Shen, C, Xu, H.E, Yang, D.H, Liu, H, Wang, M.W.
Deposit date:2022-07-21
Release date:2023-03-01
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Nat Commun, 14, 2023
4PXF
DownloadVisualize
BU of 4pxf by Molmil
Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1
Descriptor: ACETATE ION, PALMITIC ACID, Rhodopsin, ...
Authors:Szczepek, M, Scheerer, P.
Deposit date:2014-03-23
Release date:2014-09-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of a common GPCR-binding interface for G protein and arrestin.
Nat Commun, 5, 2014
4ZJ8
DownloadVisualize
BU of 4zj8 by Molmil
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Descriptor: OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, human OX1R fusion protein to P.abysii glycogen synthase
Authors:Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P, Renger, J.J, Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
5KW2
DownloadVisualize
BU of 5kw2 by Molmil
The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation
Descriptor: (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid, Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1
Authors:Ho, J.D, Chau, B, Rodgers, L, Lu, F, Wilbur, K.L, Otto, K.A, Chen, Y, Song, M, Riley, J.P, Yang, H.-C, Reynolds, N.A, Kahl, S.D, Lewis, A.P, Groshong, C, Madsen, R.E, Conners, K, Linswala, J.P, Gheyi, T, Saflor, M.D, Lee, M.R, Benach, J, Baker, K.A, Montrose-Rafizadeh, C, Genin, M.J, Miller, A.R, Hamdouchi, C.
Deposit date:2016-07-15
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural basis for GPR40 allosteric agonism and incretin stimulation.
Nat Commun, 9, 2018
7VV5
DownloadVisualize
BU of 7vv5 by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1
Descriptor: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
6H7M
DownloadVisualize
BU of 6h7m by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
8J6R
DownloadVisualize
BU of 8j6r by Molmil
Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y.
Deposit date:2023-04-26
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Orthosteric and allosteric modulation of human HCAR2 signaling complex.
Nat Commun, 14, 2023
7XV3
DownloadVisualize
BU of 7xv3 by Molmil
Cryo-EM structure of LPS-bound GPR174 in complex with Gs protein
Descriptor: (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, Engineered G protein subunit S (mini-Gs), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:He, Y, Liang, J.
Deposit date:2022-05-20
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.
Nat Commun, 14, 2023
8XJL
DownloadVisualize
BU of 8xjl by Molmil
PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Descriptor: (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ...
Authors:Zhang, X, Li, X, Liu, G, Gong, W.
Deposit date:2023-12-21
Release date:2024-02-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
8HMP
DownloadVisualize
BU of 8hmp by Molmil
GPR52 with Gs and c17
Descriptor: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Chen, B, Xu, F.
Deposit date:2022-12-05
Release date:2023-06-21
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by 19 F-NMR and cryo-electron microscopy.
MedComm (2020), 4, 2023
8I7V
DownloadVisualize
BU of 8i7v by Molmil
Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer
Descriptor: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Park, J.H, Ishimoto, N, Park, S.Y.
Deposit date:2023-02-02
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
7Y3G
DownloadVisualize
BU of 7y3g by Molmil
Cryo-EM structure of a class A orphan GPCR
Descriptor: G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F.
Deposit date:2022-06-10
Release date:2023-06-07
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structural insight into the constitutive activity of human orphan receptor GPR12.
Sci Bull (Beijing), 68, 2023

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon