PDB: 1170 件ウェブページステータス検索Chemie searchBIRD

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7P02	Human Neurokinin 1 receptor (NK1R) substance P Gs complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7P00	Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
5DSG	Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium 分子名称: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... 著者 Thal, D.M, Kobilka, B.K, Sexton, P.M, Christopoulos, A. 登録日 2015-09-17 公開日 2016-03-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of the M1 and M4 muscarinic acetylcholine receptors. Nature, 531, 2016
5EN0	Crystal Structure of T94I rhodopsin mutant 分子名称: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-3, PALMITIC ACID, ... 著者 Singhal, A, Guo, Y, Matkovic, M, Schertler, G, Deupi, X, Yan, E, Standfuss, J. 登録日 2015-11-08 公開日 2016-08-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Structural role of the T94I rhodopsin mutation in congenital stationary night blindness. Embo Rep., 17, 2016
7PX4	Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2113 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... 著者 Claff, T, Klapschinski, T.A, Tiruttani Subhramanyam, U.K, Vaassen, V.J, Schlegel, J.G, Vielmuth, C, Voss, J.H, Labahn, J, Muller, C.E. 登録日 2021-10-07 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates. Angew.Chem.Int.Ed.Engl., 61, 2022
7PYR	Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2115 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[2-[2-[2-[2-[2-[4-[4-[2-[7-azanyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]piperazin-1-yl]phenoxy]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[5-[2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-8-yl]pentyl]ethanamide, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... 著者 Claff, T, Klapschinski, T.A, Tiruttani Subhramanyam, U.K, Vaassen, V.J, Schlegel, J.G, Vielmuth, C, Voss, J.H, Labahn, J, Muller, C.E. 登録日 2021-10-11 公開日 2022-03-02 最終更新日 2022-05-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates. Angew.Chem.Int.Ed.Engl., 61, 2022
7PP1	Crystal structure of the P2Y12 receptor in complex with the inverse agonist selatogrel. 分子名称: CHOLESTEROL, P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, Selatogrel 著者 Mac Sweeney, A, Tidten-Luksch, N. 登録日 2021-09-13 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation. Biochem Pharmacol, 206, 2022
7QVM	Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex 分子名称: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Waltenspuhl, Y, Ehrenmann, J, Vacca, S, Thom, C, Medalia, O, Pluckthun, A. 登録日 2022-01-21 公開日 2022-08-10 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nat Commun, 13, 2022
7R0C	Structure of the AVP-V2R-arrestin2-ScFv30 complex 分子名称: AVP, Arrestin2, ScFv30, ... 著者 Bous, J, Fouillen, A, Trapani, S, Granier, S, Mouillac, B, Bron, P. 登録日 2022-02-01 公開日 2022-09-14 実験手法 ELECTRON MICROSCOPY (4.73 Å) 主引用文献 Structure of the vasopressin hormone-V2 receptor-beta-arrestin1 ternary complex. Sci Adv, 8, 2022
5G53	Structure of the adenosine A2A receptor bound to an engineered G protein 分子名称: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G. 登録日 2016-05-19 公開日 2016-08-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein Nature, 536, 2016
7RM5	MicroED structure of the human adenosine receptor at 2.8A 分子名称: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 chimera, CHOLESTEROL, ... 著者 Martynowycz, M.W, Shiriaeva, A, Ge, X, Hattne, J, Nannenga, B.L, Cherezov, V, Gonen, T. 登録日 2021-07-26 公開日 2021-09-08 最終更新日 2023-10-18 実験手法 ELECTRON CRYSTALLOGRAPHY (2.79 Å) 主引用文献 MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP. Proc.Natl.Acad.Sci.USA, 118, 2021
5GLH	Human endothelin receptor type-B in complex with ET-1 分子名称: Endothelin Receptor Subtype-B, Peptide from Endothelin-1 著者 Shihoya, W, Nishizawa, T, Okuta, A, Tani, K, Fujiyoshi, Y, Dohmae, N, Nureki, O, Doi, T. 登録日 2016-07-11 公開日 2016-09-07 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Activation mechanism of endothelin ETB receptor by endothelin-1. Nature, 537, 2016
7RMG	Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. 登録日 2021-07-27 公開日 2021-11-03 最終更新日 2022-01-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
7RMH	Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. 登録日 2021-07-27 公開日 2021-11-03 最終更新日 2022-01-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
7RMI	SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. 登録日 2021-07-27 公開日 2021-11-03 最終更新日 2022-01-05 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
5GLI	Human endothelin receptor type-B in the ligand-free form 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Endothelin Receptor Subtype-B, OLEIC ACID, ... 著者 Shihoya, W, Nishizawa, T, Okuta, A, Tani, K, Fujiyoshi, Y, Dohmae, N, Nureki, O, Doi, T. 登録日 2016-07-11 公開日 2016-09-07 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Activation mechanism of endothelin ETB receptor by endothelin-1. Nature, 537, 2016
7LD3	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. 登録日 2021-01-12 公開日 2021-09-08 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
7LD4	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. 登録日 2021-01-12 公開日 2021-09-08 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
7LJC	Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein 分子名称: (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, ... 著者 Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. 登録日 2021-01-28 公開日 2021-03-03 最終更新日 2021-05-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res., 31, 2021
7LJD	Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein 分子名称: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... 著者 Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. 登録日 2021-01-28 公開日 2021-03-03 最終更新日 2021-05-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res., 31, 2021
7MBX	Human Cholecystokinin 1 receptor (CCK1R) Gs complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (1.95 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
7MBY	Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (2.44 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
4BEZ	Night blindness causing G90D rhodopsin in the active conformation 分子名称: ACETATE ION, PALMITIC ACID, RHODOPSIN, ... 著者 Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J. 登録日 2013-03-12 公開日 2013-04-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin. Embo Rep., 14, 2013
4BEY	Night blindness causing G90D rhodopsin in complex with GaCT2 peptide 分子名称: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ... 著者 Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J. 登録日 2013-03-12 公開日 2013-05-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin. Embo Rep., 14, 2013
7M8W	XFEL crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2 分子名称: 15R-methyl-prostaglandin D2, CITRATE ANION, Prostaglandin D2 receptor 2, ... 著者 Shiriaeva, A, Han, G.W, Cherezov, V. 登録日 2021-03-30 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Molecular basis for lipid recognition by the prostaglandin D 2 receptor CRTH2. Proc.Natl.Acad.Sci.USA, 118, 2021

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