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7RTG
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BU of 7rtg by Molmil
Crystal Structure of the Human Adenosine Deaminase 1
Descriptor: Adenosine deaminase, ZINC ION
Authors:Ma, M.T, Lieberman, R.L, Blazeck, J, Jennings, M.R.
Deposit date:2021-08-13
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.591 Å)
Cite:Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation.
Acta Crystallogr D Struct Biol, 78, 2022
4GXW
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BU of 4gxw by Molmil
Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn
Descriptor: Adenosine deaminase, CHLORIDE ION, ZINC ION
Authors:Vetting, M.W, Goble, A.M, Morisco, L.L, Wasserman, S.R, Sojitra, S, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2012-09-04
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn
To be Published
1KRM
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BU of 1krm by Molmil
Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside
Descriptor: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ZINC ION, adenosine deaminase
Authors:Kinoshita, T.
Deposit date:2002-01-10
Release date:2003-01-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside.
Acta Crystallogr.,Sect.D, 59, 2003
2Z7G
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BU of 2z7g by Molmil
Crystal structure of adenosine deaminase ligated with EHNA
Descriptor: (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2007-08-20
Release date:2008-07-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Conformational change of adenosine deaminase during ligand-exchange in a crystal
Biochem.Biophys.Res.Commun., 373, 2008
3RYS
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BU of 3rys by Molmil
The crystal structure of adenine deaminase (AAur1117) from Arthrobacter aurescens
Descriptor: ADENINE, Adenosine deaminase 1, ZINC ION
Authors:Zhang, Z, Goble, A.M, Raushel, F.M, Swaminathan, S.
Deposit date:2011-05-11
Release date:2011-05-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:The crystal structure of adenine deaminase (AAur1117) from Arthrobacter aurescens
To be Published
3T1G
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BU of 3t1g by Molmil
Engineering of organophosphate hydrolase by computational design and directed evolution
Descriptor: CALCIUM ION, ZINC ION, organophosphate hydrolase
Authors:Takeuchi, R, Stoddard, B.L.
Deposit date:2011-07-21
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat.Chem.Biol., 8, 2012
6N91
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BU of 6n91 by Molmil
Crystal Structure of Adenosine Deaminase from Vibrio cholerae Complexed with Pentostatin (Deoxycoformycin)
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYCOFORMYCIN, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ...
Authors:Maltseva, N, Kim, Y, Endres, M, Welk, L, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-11-30
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Adenosine Deaminase from Vibrio cholerae Complexed with Pentostatin (Deoxycoformycin) (CASP target)
To Be Published
6N9M
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BU of 6n9m by Molmil
Crystal Structure of Adenosine Deaminase from Salmonella typhimurium with Pentostatin (Deoxycoformycin)
Descriptor: 2'-DEOXYCOFORMYCIN, Adenosine deaminase, CALCIUM ION, ...
Authors:Maltseva, N, Kim, Y, Grimshaw, S, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-12-03
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.449 Å)
Cite:Crystal Structure of Adenosine Deaminase from Salmonella typhimurium Complexed with Pentostatin (Deoxycoformycin) (CASP target)
To Be Published
1FKW
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BU of 1fkw by Molmil
MURINE ADENOSINE DEAMINASE (D295E)
Descriptor: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
Authors:Wilson, D.K, Quiocho, F.A.
Deposit date:1996-02-29
Release date:1996-08-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
1FKX
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BU of 1fkx by Molmil
MURINE ADENOSINE DEAMINASE (D296A)
Descriptor: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:Wilson, D.K, Quiocho, F.A.
Deposit date:1996-02-29
Release date:1996-08-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
3EWC
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BU of 3ewc by Molmil
Crystal Structure of adenosine deaminase from Plasmodial vivax in complex with MT-coformycin
Descriptor: (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Adenosine deaminase, ZINC ION
Authors:Schramm, V.L, Almo, S.C, Cassera, M.B, Ho, M.C.
Deposit date:2008-10-14
Release date:2009-09-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Biochemistry, 48, 2009
3EWD
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BU of 3ewd by Molmil
Crystal structure of adenosine deaminase mutant (delta Asp172) from Plasmodium vivax in complex with MT-coformycin
Descriptor: (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Adenosine deaminase, ZINC ION
Authors:Schramm, V.L, Almo, S.C, Cassera, M.B, Ho, M.C.
Deposit date:2008-10-14
Release date:2009-09-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Biochemistry, 48, 2009
1A4M
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BU of 1a4m by Molmil
ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0
Descriptor: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:Wang, Z, Quiocho, F.A.
Deposit date:1998-01-31
Release date:1998-10-14
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1A4L
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BU of 1a4l by Molmil
ADA STRUCTURE COMPLEXED WITH DEOXYCOFORMYCIN AT PH 7.0
Descriptor: 2'-DEOXYCOFORMYCIN, ADENOSINE DEAMINASE, ZINC ION
Authors:Wang, Z, Quiocho, F.A.
Deposit date:1998-01-31
Release date:1998-10-14
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1ADD
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BU of 1add by Molmil
A PRE-TRANSITION STATE MIMIC OF AN ENZYME: X-RAY STRUCTURE OF ADENOSINE DEAMINASE WITH BOUND 1-DEAZA-ADENOSINE AND ZINC-ACTIVATED WATER
Descriptor: 1-DEAZA-ADENOSINE, ADENOSINE DEAMINASE, ZINC ION
Authors:Wilson, D.K, Quiocho, F.A.
Deposit date:1992-12-22
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water.
Biochemistry, 32, 1993
2PGF
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BU of 2pgf by Molmil
Crystal structure of adenosine deaminase from Plasmodium vivax in complex with adenosine
Descriptor: ACETONITRILE, ADENOSINE, ZINC ION, ...
Authors:Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-04-09
Release date:2007-04-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
2PGR
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BU of 2pgr by Molmil
Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin
Descriptor: 2'-DEOXYCOFORMYCIN, ACETONITRILE, ZINC ION, ...
Authors:Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-04-10
Release date:2007-04-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
2QVN
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BU of 2qvn by Molmil
Crystal structure of adenosine deaminase from Plasmodium vivax in complex with guanosine
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Adenosine deaminase, GUANOSINE
Authors:Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-08-08
Release date:2007-09-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
2ADA
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BU of 2ada by Molmil
ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS
Descriptor: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:Wilson, D.K, Quiocho, F.A.
Deposit date:1994-12-02
Release date:1995-03-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.
Science, 252, 1991
2AMX
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BU of 2amx by Molmil
Crystal structure of Plasmodium Yoelii Adenosine deaminase (PY02076)
Descriptor: COBALT (II) ION, UNKNOWN ATOM OR ION, adenosine deaminase
Authors:Dong, A, Vedadi, M, Wasney, G, Zhao, Y, Lew, J, Alam, Z, Melone, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC)
Deposit date:2005-08-10
Release date:2005-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
3IAR
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BU of 3iar by Molmil
The crystal structure of human adenosine deaminase
Descriptor: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Adenosine deaminase, GLYCEROL, ...
Authors:Ugochukwu, E, Zhang, Y, Hapka, E, Yue, W.W, Bray, J.E, Muniz, J, Burgess-Brown, N, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2009-07-14
Release date:2009-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The crystal structure of human adenosine deaminase
To be Published
3KM8
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BU of 3km8 by Molmil
Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine
Descriptor: 9-DEAZAINOSINE, Adenosine deaminase, ZINC ION
Authors:Fan, X, Gao, Y.
Deposit date:2009-11-10
Release date:2010-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Catalytic Mechanism of Adenosine Deaminase from Mouse: An Experimental and Theoretical Study
To be Published
2E1W
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BU of 2e1w by Molmil
Crystal structure of adenosine deaminase complexed with potent inhibitors
Descriptor: 1-{(1R,2S)-2-HYDROXY-1-[2-(1-NAPHTHYL)ETHYL]PROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2006-10-30
Release date:2006-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors
J.Med.Chem., 47, 2004
1NDV
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BU of 1ndv by Molmil
Crystal Structure of Adenosine Deaminase complexed with FR117016
Descriptor: Adenosine deaminase, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE, ZINC ION
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
1NDY
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BU of 1ndy by Molmil
Crystal Structure of Adenosine Deaminase Complexed with FR230513
Descriptor: 1-((1R)-1-(HYDROXYMETHYL)-3-(1-NAPHTHYL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004

 

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