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7UBX
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BU of 7ubx by Molmil
Structure of a pore forming fragment of Clostridium difficile toxin A in complex with VHH AA6
Descriptor: Nanobody VHH AA6, Toxin A
Authors:Chen, B, Rongsheng, J, Kay, P.
Deposit date:2022-03-15
Release date:2022-11-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies.
Front Immunol, 13, 2022
6OQ6
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BU of 6oq6 by Molmil
Structure of the pore forming fragment of Clostridium difficile toxin B in complex with VHH 5D
Descriptor: 5D, Toxin B
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
8P51
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BU of 8p51 by Molmil
Photorhabdus luminescens Makes caterpillars floppy (Mcf) toxin with the C-terminal deletion
Descriptor: Toxin protein
Authors:Belyy, A, Heilen, P, Hofnagel, O, Raunser, S.
Deposit date:2023-05-23
Release date:2023-11-01
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structure and activation mechanism of the Makes caterpillars floppy 1 toxin.
Nat Commun, 14, 2023
8P52
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BU of 8p52 by Molmil
Photorhabdus luminescens Makes caterpillars floppy (Mcf) toxin
Descriptor: Toxin protein
Authors:Belyy, A, Heilen, P, Hofnagel, O, Raunser, S.
Deposit date:2023-05-23
Release date:2023-11-01
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and activation mechanism of the Makes caterpillars floppy 1 toxin.
Nat Commun, 14, 2023
4R04
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BU of 4r04 by Molmil
Clostridium difficile Toxin A (TcdA)
Descriptor: Toxin A, ZINC ION
Authors:Lacy, D.B, Spiller, B.W, Rutherford, S.A.
Deposit date:2014-07-29
Release date:2016-01-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Glucosyl Transferase Structure
Nat Microbiol, 2016
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
Authors:Chen, P, Jin, R.
Deposit date:2021-04-27
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
7U1Z
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BU of 7u1z by Molmil
Crystal structure of the DRBD and CROPs of TcdA
Descriptor: SULFATE ION, Toxin A
Authors:Baohua, C, Peng, C, Kay, P, Rongsheng, J.
Deposit date:2022-02-22
Release date:2022-03-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Structure and conformational dynamics of Clostridioides difficile toxin A.
Life Sci Alliance, 5, 2022
8X2H
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BU of 8x2h by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its closed conformation
Descriptor: Cytotoxin-L, ZINC ION
Authors:Zhan, X, Tao, L.
Deposit date:2023-11-09
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8X2I
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BU of 8x2i by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its open conformation
Descriptor: Cytotoxin-L, ZINC ION
Authors:Zhan, X, Tao, L.
Deposit date:2023-11-09
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
7V1N
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BU of 7v1n by Molmil
Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI
Descriptor: Isoform Beta of Tissue factor pathway inhibitor, Toxin B
Authors:Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L.
Deposit date:2021-08-05
Release date:2022-02-23
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.
Cell, 185, 2022
6OQ5
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BU of 6oq5 by Molmil
Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
Descriptor: 5D, 7F, E3, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.87 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6AR6
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BU of 6ar6 by Molmil
Clostridioides difficile toxinB with DLD-4 darpin
Descriptor: DLD-4 darpin, Toxin B
Authors:Zhang, J, Jiang, M.
Deposit date:2017-08-21
Release date:2018-08-22
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Clostridioides difficile toxinB with DLD-4 darpin
To Be Published
6C0B
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BU of 6c0b by Molmil
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-2, MALONATE ION, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2017-12-28
Release date:2018-05-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.
Science, 360, 2018
8JB5
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BU of 8jb5 by Molmil
The cryo-EM structure of Paeniclostridium sordellii lethal toxin (TcsL)
Descriptor: Cytotoxin-L, ZINC ION
Authors:Zhan, X, Tao, L.
Deposit date:2023-05-08
Release date:2023-12-13
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8P50
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BU of 8p50 by Molmil
Photorhabdus luminescens Makes caterpillars floppy (Mcf) toxin with the C-terminal deletion in complex with Arf3
Descriptor: ADP-ribosylation factor 3, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Belyy, A, Heilen, P, Hofnagel, O, Raunser, S.
Deposit date:2023-05-23
Release date:2023-11-01
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Structure and activation mechanism of the Makes caterpillars floppy 1 toxin.
Nat Commun, 14, 2023
7N95
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BU of 7n95 by Molmil
state 1 of TcdB and FZD2 at pH5
Descriptor: Frizzled-2, Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-16
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9Q
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BU of 7n9q by Molmil
State 3 of TcdB and FZD2 at pH5
Descriptor: Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-18
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N97
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BU of 7n97 by Molmil
State 2 of TcdB and FZD2 at pH5
Descriptor: Frizzled-2, Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-17
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Structural Basis for Receptor Recognition of the Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9R
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BU of 7n9r by Molmil
state 4 of TcdB and FZD2 at pH5
Descriptor: Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-18
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9S
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BU of 7n9s by Molmil
TcdB and frizzled-2 CRD complex
Descriptor: Frizzled-2, Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-18
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9Y
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BU of 7n9y by Molmil
Full-length TcdB and CSPG4 (401-560) complex
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-18
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N8X
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BU of 7n8x by Molmil
Partial C. difficile TcdB and CSPG4 fragment
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B
Authors:Jiang, M, Zhang, J.
Deposit date:2021-06-16
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7POG
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BU of 7pog by Molmil
High-resolution structure of native toxin A from Clostridioides difficile
Descriptor: Toxin A, ZINC ION
Authors:Boesen, T, Joergensen, R, Aminzadeh, A, Engelbrecht Larsen, C.
Deposit date:2021-09-08
Release date:2021-12-08
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:High-resolution structure of native toxin A from Clostridioides difficile.
Embo Rep., 23, 2022

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數據於2024-03-27公開中

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