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7UBY
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BU of 7uby by Molmil
Structure of the GTD domain of Clostridium difficile toxin A in complex with VHH AH3
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Glucosyltransferase TcdA, ...
Authors:Chen, B, Rongsheng, J, Kay, P.
Deposit date:2022-03-15
Release date:2022-11-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies.
Front Immunol, 13, 2022
3SRZ
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BU of 3srz by Molmil
Clostridium difficile toxin A (TcdA) glucolsyltransferase domain bound to UDP-glucose
Descriptor: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B.
Deposit date:2011-07-07
Release date:2012-02-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
3SS1
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BU of 3ss1 by Molmil
Clostridium difficile toxin A (TcdA) glucolsyltransferase domain
Descriptor: MANGANESE (II) ION, Toxin A
Authors:Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B.
Deposit date:2011-07-07
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
4DMW
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BU of 4dmw by Molmil
Crystal structure of the GT domain of Clostridium difficile toxin A (TcdA) in complex with UDP and Manganese
Descriptor: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE
Authors:Malito, E, D'Urzo, N, Bottomley, M.J, Biancucci, M, Scarselli, M, Maione, D, Martinelli, M.
Deposit date:2012-02-08
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
Febs J., 279, 2012
4DMV
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BU of 4dmv by Molmil
Crystal structure of the GT domain of Clostridium difficile Toxin A
Descriptor: Toxin A
Authors:Malito, E, D'Urzo, N, Bottomley, M.J, Biancucci, M, Maione, D, Scarselli, M, Martinelli, M.
Deposit date:2012-02-08
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
Febs J., 279, 2012
2VK9
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BU of 2vk9 by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF ALPHA-TOXIN FROM CLOSTRIDIUM NOVYI
Descriptor: ALPHA-TOXIN
Authors:Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E.
Deposit date:2007-12-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
5UQL
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BU of 5uql by Molmil
Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
Descriptor: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Alvin, J.W, Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQK
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BU of 5uqk by Molmil
Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
Descriptor: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Alvin, J.W, Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
4R04
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BU of 4r04 by Molmil
Clostridium difficile Toxin A (TcdA)
Descriptor: Toxin A, ZINC ION
Authors:Lacy, D.B, Spiller, B.W, Rutherford, S.A.
Deposit date:2014-07-29
Release date:2016-01-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Glucosyl Transferase Structure
Nat Microbiol, 2016
8JB5
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BU of 8jb5 by Molmil
The cryo-EM structure of Paeniclostridium sordellii lethal toxin (TcsL)
Descriptor: Cytotoxin-L, ZINC ION
Authors:Zhan, X, Tao, L.
Deposit date:2023-05-08
Release date:2023-12-13
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
6OQ5
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BU of 6oq5 by Molmil
Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
Descriptor: 5D, 7F, E3, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.87 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6AR6
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BU of 6ar6 by Molmil
Clostridioides difficile toxinB with DLD-4 darpin
Descriptor: DLD-4 darpin, Toxin B
Authors:Zhang, J, Jiang, M.
Deposit date:2017-08-21
Release date:2018-08-22
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Clostridioides difficile toxinB with DLD-4 darpin
To Be Published
2VKD
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BU of 2vkd by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND MANGANESE ION
Descriptor: CYTOTOXIN L, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E.
Deposit date:2007-12-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
6OQ8
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BU of 6oq8 by Molmil
Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH 7F
Descriptor: 7F, Toxin B
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6OQ7
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BU of 6oq7 by Molmil
Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH E3
Descriptor: E3, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
8X2H
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BU of 8x2h by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its closed conformation
Descriptor: Cytotoxin-L, ZINC ION
Authors:Zhan, X, Tao, L.
Deposit date:2023-11-09
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8X2I
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BU of 8x2i by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its open conformation
Descriptor: Cytotoxin-L, ZINC ION
Authors:Zhan, X, Tao, L.
Deposit date:2023-11-09
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
7V1N
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BU of 7v1n by Molmil
Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI
Descriptor: Isoform Beta of Tissue factor pathway inhibitor, Toxin B
Authors:Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L.
Deposit date:2021-08-05
Release date:2022-02-23
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.
Cell, 185, 2022
2BVL
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BU of 2bvl by Molmil
Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion
Descriptor: HEXATANTALUM DODECABROMIDE, MANGANESE (II) ION, SULFATE ION, ...
Authors:Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E.
Deposit date:2005-06-30
Release date:2005-08-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2BVM
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BU of 2bvm by Molmil
Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion
Descriptor: MANGANESE (II) ION, SULFATE ION, TOXIN B, ...
Authors:Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E.
Deposit date:2005-06-30
Release date:2005-08-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2VL8
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BU of 2vl8 by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION
Descriptor: CALCIUM ION, CASTANOSPERMINE, CYTOTOXIN L, ...
Authors:Jank, T, Ziegler, M.O.P, Schulz, G.E, Aktories, K.
Deposit date:2008-01-09
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine.
FEBS Lett., 582, 2008
2VKH
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BU of 2vkh by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND CALCIUM ION
Descriptor: CALCIUM ION, CYTOTOXIN L, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E.
Deposit date:2007-12-19
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
7LOV
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BU of 7lov by Molmil
Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin
Descriptor: (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, GLYCEROL, MANGANESE (II) ION, ...
Authors:Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2021-02-10
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun, 12, 2021
7LOU
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BU of 7lou by Molmil
Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and isofagomine
Descriptor: 1,2-ETHANEDIOL, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, Glucosyltransferase TcdB, ...
Authors:Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2021-02-10
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun, 12, 2021
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
Authors:Chen, P, Jin, R.
Deposit date:2021-04-27
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021

 

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數據於2024-03-27公開中

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