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8T5E
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BU of 8t5e by Molmil
De novo design of high-affinity protein binders to bioactive helical peptides
Descriptor: Bcl-2-like protein 11, Bim_fulldiff
Authors:Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A.
Deposit date:2023-06-13
Release date:2024-01-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
6X8O
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BU of 6x8o by Molmil
BimBH3 peptide tetramer
Descriptor: Bcl-2-like protein 11, THIOCYANATE ION
Authors:Robin, A.Y, Westphal, D, Uson, I, Czabotar, P.E.
Deposit date:2020-06-01
Release date:2020-09-09
Last modified:2021-02-17
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.
Structure, 29, 2021
4UF3
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Deerpox virus DPV022 in complex with Bim BH3
Descriptor: Antiapoptotic membrane protein, Bcl-2-like protein 11
Authors:Burton, D.R, Kvansakul, M.
Deposit date:2014-12-23
Release date:2015-08-05
Last modified:2021-06-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of Deerpox Virus-Mediated Inhibition of Apoptosis.
Acta Crystallogr.,Sect.D, 71, 2015
6TQQ
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BU of 6tqq by Molmil
Structural insight into tanapoxvirus mediated inhibition of apoptosis
Descriptor: 16L protein, Bcl-2-like protein 11, SODIUM ION
Authors:Suraweera, C.D, Hinds, M.G, Kvansakul, M.
Deposit date:2019-12-17
Release date:2020-06-03
Last modified:2020-12-16
Method:X-RAY DIFFRACTION (3.0017972 Å)
Cite:Structural insight into tanapoxvirus-mediated inhibition of apoptosis.
Febs J., 287, 2020
4D2M
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BU of 4d2m by Molmil
Vaccinia Virus F1L bound to Bim BH3
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, BCL-2-LIKE PROTEIN 11, CHLORIDE ION, ...
Authors:Kvansakul, M, Colman, P.M.
Deposit date:2014-05-12
Release date:2014-06-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
5C3G
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BU of 5c3g by Molmil
Crystal structure of Bcl-xl bound to BIM-MM
Descriptor: Bcl-2-like protein 1,Bcl-2-like protein 1, Bcl-2-like protein 11
Authors:Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J.
Deposit date:2015-06-17
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.
Chem Sci, 7, 2016
2NL9
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BU of 2nl9 by Molmil
Crystal structure of the Mcl-1:Bim BH3 complex
Descriptor: Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ...
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
1PQ1
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BU of 1pq1 by Molmil
Crystal structure of Bcl-xl/Bim
Descriptor: Apoptosis regulator Bcl-X, BCL2-like protein 11
Authors:Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W.
Deposit date:2003-06-17
Release date:2003-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function
Immunity, 19, 2003
2K7W
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BU of 2k7w by Molmil
BAX Activation is Initiated at a Novel Interaction Site
Descriptor: Apoptosis regulator BAX, Bcl-2-like protein 11
Authors:Gavathiotis, E, Suzuki, M, Davis, M.L, Pitter, K, Bird, G.H, Katz, S.G, Tu, H.C, Kim, H, Cheng, E.H, Tjandra, N, Walensky, L.D.
Deposit date:2008-08-27
Release date:2008-10-21
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:BAX activation is initiated at a novel interaction site.
Nature, 455, 2008
4QVF
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BU of 4qvf by Molmil
Crystal structure of Bcl-xL in complex with BIM BH3 domain
Descriptor: Bcl-2-like protein 1, Peptide from Bcl-2-like protein 11
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2014-07-15
Release date:2015-06-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.531 Å)
Cite:Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Proteins, 83, 2015
6QFI
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BU of 6qfi by Molmil
Structure of human Mcl-1 in complex with BIM BH3 peptide
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E.
Deposit date:2019-01-10
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
3D7V
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BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
6RJP
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BU of 6rjp by Molmil
Bfl-1 in complex with alpha helical peptide
Descriptor: Bcl-2-like protein 11, Bcl-2-related protein A1
Authors:Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M.
Deposit date:2019-04-29
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem.Biol.Drug Des., 95, 2020
3FDL
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BU of 3fdl by Molmil
Bim BH3 peptide in complex with Bcl-xL
Descriptor: Apoptosis regulator Bcl-X, Bcl-2-like protein 11
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
4A1U
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BU of 4a1u by Molmil
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
Descriptor: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ...
Authors:Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
Deposit date:2011-09-20
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
4A1W
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BU of 4a1w by Molmil
Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL
Descriptor: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1
Authors:Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
Deposit date:2011-09-20
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
4B4S
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BU of 4b4s by Molmil
Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex
Descriptor: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
Authors:Rautureau, G.J.P, Hinds, M.G, Kvansakul, M.
Deposit date:2012-08-01
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
6UA3
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BU of 6ua3 by Molmil
Human Mcl-1 in complex with a modified Bim BH3 peptide
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide
Authors:Mandal, T, Grant, R.A, Keating, A.E.
Deposit date:2019-09-10
Release date:2020-09-16
Method:X-RAY DIFFRACTION (1.552 Å)
Cite:Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published
6UAB
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BU of 6uab by Molmil
Human Mcl-1 in complex with a modified unnatural Bim BH3 peptide
Descriptor: ADAMANTANE, Induced myeloid leukemia cell differentiation protein Mcl-1, modified unnatural Bim BH3 peptide
Authors:Mandal, T, Grant, R.A, Keating, A.E.
Deposit date:2019-09-10
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published
6VBX
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BU of 6vbx by Molmil
Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide
Authors:Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z.
Deposit date:2019-12-19
Release date:2020-12-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
J.Med.Chem., 64, 2021
2V6Q
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BU of 2v6q by Molmil
Crystal Structure of a BHRF-1 : Bim BH3 complex
Descriptor: BCL-2-LIKE PROTEIN 11, BHRF1 PROTEIN, BROMIDE ION
Authors:Kvansakul, M, Huang, D.C.S, Colman, P.M.
Deposit date:2007-07-20
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2VM6
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BU of 2vm6 by Molmil
Human Bcl2-A1 in complex with Bim-BH3 peptide
Descriptor: BCL-2-LIKE PROTEIN 11, BCL-2-RELATED PROTEIN A1, SULFATE ION
Authors:Herman, M.D, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2008-01-23
Release date:2008-02-05
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim.
FEBS Lett., 582, 2008
2WH6
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BU of 2wh6 by Molmil
Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain
Descriptor: BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ...
Authors:Kvansakul, M, Huang, D.C.S, Colman, P.M.
Deposit date:2009-05-01
Release date:2010-05-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
3IO8
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BU of 3io8 by Molmil
BimL12F in complex with Bcl-xL
Descriptor: Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D, Smith, B.J, Czabotar, P.E, Yang, H, Sleebs, B.E, Lessene, G.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3IO9
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BU of 3io9 by Molmil
BimL12Y in complex with Mcl-1
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009

 

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數據於2024-03-27公開中

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