PDB: 12 resultsInfo pagesStatus searchChemie searchBIRD

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2LQ7	E2 binding surface on Uba3 beta-grasp domain undergoes a conformational transition Descriptor: NEDD8-activating enzyme E1 catalytic subunit Authors: Elgin, E.S, Peterson, F.C, Volkman, B.F. Deposit date: 2012-02-27 Release date: 2012-07-25 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: E2-binding surface on Uba3 beta-grasp domain undergoes a conformational transition. Proteins, 80, 2012
3GZN	Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Sintchak, M.D. Deposit date: 2009-04-07 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol.Cell, 37, 2010
2NVU	Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, ... Authors: Huang, D.T, Hunt, H.W, Zhuang, M, Ohi, M.D, Holton, J.M, Schulman, B.A. Deposit date: 2006-11-13 Release date: 2007-01-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature, 445, 2007
1Y8X	Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1 Descriptor: Ubiquitin-activating enzyme E1C, Ubiquitin-conjugating enzyme E2 M Authors: Huang, D.T, Paydar, A, Zhuang, M, Waddell, M.B, Holton, J.M, Schulman, B.A. Deposit date: 2004-12-13 Release date: 2005-02-08 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Mol.Cell, 17, 2005
1YOV	Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8 Descriptor: Amyloid protein-binding protein 1, Ubiquitin-activating enzyme E1C, ZINC ION Authors: Walden, H, Podgorski, M.S, Schulman, B.A. Deposit date: 2005-01-28 Release date: 2005-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8 Nature, 422, 2003
1R4N	APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ubiquitin-like protein NEDD8, ZINC ION, ... Authors: Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A. Deposit date: 2003-10-07 Release date: 2003-12-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol.Cell, 12, 2003
1R4M	APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex Descriptor: Ubiquitin-like protein NEDD8, ZINC ION, amyloid beta precursor protein-binding protein 1, ... Authors: Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A. Deposit date: 2003-10-07 Release date: 2003-12-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol.Cell, 12, 2003
1TT5	Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 Descriptor: Ubiquitin-conjugating enzyme E2 M, ZINC ION, amyloid protein-binding protein 1, ... Authors: Huang, D.T, Miller, D.W, Mathew, R, Cassell, R, Holton, J.M, Roussel, M.F, Schulman, B.A. Deposit date: 2004-06-21 Release date: 2004-09-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Nat.Struct.Mol.Biol., 11, 2004
3DBL	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190wt-NEDD8Ala72Gln) Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Souphron, J, Schulman, B.A. Deposit date: 2008-06-01 Release date: 2008-08-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3DBH	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Ala-NEDD8Ala72Arg) Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Souphron, J, Schulman, B.A. Deposit date: 2008-05-31 Release date: 2008-08-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3DBR	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Gln-NEDD8Ala72Arg) Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Souphron, J, Schulman, B.A. Deposit date: 2008-06-02 Release date: 2008-08-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3FN1	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Descriptor: NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F Authors: Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A. Deposit date: 2008-12-22 Release date: 2009-03-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification Mol.Cell, 33, 2009