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7MGL
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BU of 7mgl by Molmil
Structure of human TRPML1 with ML-SI3
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, Mucolipin-1, N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide
Authors:Schmiege, P, Li, X.
Deposit date:2021-04-12
Release date:2021-06-16
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Atomic insights into ML-SI3 mediated human TRPML1 inhibition.
Structure, 29, 2021
5K47
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BU of 5k47 by Molmil
CryoEM structure of the human Polycystin-2/PKD2 TRP channel
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2016-05-20
Release date:2016-08-24
Last modified:2020-10-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
6T9N
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BU of 6t9n by Molmil
CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, Q, Pike, A.C.W, Grieben, M, Baronina, A, Nasrallah, C, Shintre, C, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-10-28
Release date:2019-11-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Structure, 28, 2020
6T9O
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BU of 6t9o by Molmil
CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(3,5)P2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, Q, Pike, A.C.W, Grieben, M, Baronina, A, Nasrallah, C, Shintre, C, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-10-28
Release date:2019-11-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Structure, 28, 2020
7D7E
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BU of 7d7e by Molmil
Structure of PKD1L3-CTD/PKD2L1 in apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ...
Authors:Su, Q, Chen, M, Li, B, Wang, Y, Jing, D, Zhan, X, Yu, Y, Shi, Y.
Deposit date:2020-10-03
Release date:2021-08-25
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Nat Commun, 12, 2021
7D7F
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BU of 7d7f by Molmil
Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ...
Authors:Su, Q, Shi, Y.G.
Deposit date:2020-10-03
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Nat Commun, 12, 2021
7DYS
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BU of 7dys by Molmil
CryoEM structure of full length mouse TRPML2
Descriptor: Mucolipin-2
Authors:Song, X.J, Li, J, Duan, J.J, Zhang, J.
Deposit date:2021-01-22
Release date:2022-03-23
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Cryo-EM structure of mouse TRPML2 in lipid nanodiscs.
J.Biol.Chem., 298, 2022
5MKE
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BU of 5mke by Molmil
cryoEM Structure of Polycystin-2 in complex with cations and lipids
Descriptor: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wilkes, M, Madej, M.G, Ziegler, C.
Deposit date:2016-12-04
Release date:2017-01-18
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Nat. Struct. Mol. Biol., 24, 2017
5MKF
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BU of 5mkf by Molmil
cryoEM Structure of Polycystin-2 in complex with calcium and lipids
Descriptor: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wilkes, M, Madej, M.G, Ziegler, C.
Deposit date:2016-12-04
Release date:2017-01-18
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Nat. Struct. Mol. Biol., 24, 2017
6WB8
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BU of 6wb8 by Molmil
Cryo-EM structure of PKD2 C331S disease variant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Cao, E, Wang, J, Decaen, P.G.
Deposit date:2020-03-26
Release date:2020-04-22
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.
Proc.Natl.Acad.Sci.USA, 117, 2020
5T4D
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BU of 5t4d by Molmil
Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2
Authors:Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E.
Deposit date:2016-08-29
Release date:2016-11-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Cell, 167, 2016
7SQ9
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BU of 7sq9 by Molmil
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Descriptor: (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gan, N, Han, Y, Jiang, Y.
Deposit date:2021-11-04
Release date:2022-02-02
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.11 Å)
Cite:Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SQ8
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BU of 7sq8 by Molmil
Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION
Authors:Gan, N, Han, Y, Jiang, Y.
Deposit date:2021-11-04
Release date:2022-02-02
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.598 Å)
Cite:Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SQ7
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BU of 7sq7 by Molmil
Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution
Descriptor: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, ...
Authors:Gan, N, Han, Y, Jiang, Y.
Deposit date:2021-11-04
Release date:2022-02-02
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.41 Å)
Cite:Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SQ6
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BU of 7sq6 by Molmil
Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1, ...
Authors:Gan, N, Han, Y, Jiang, Y.
Deposit date:2021-11-04
Release date:2022-02-02
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
5W3S
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BU of 5w3s by Molmil
Cryo-electron microscopy structure of a TRPML3 ion channel
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Mucolipin-3 isoform 1, ...
Authors:Hirschi, M, Herzik, M.A, Wie, J, Suo, Y, Borschel, W.F, Ren, D, Lander, G.C, Lee, S.Y.
Deposit date:2017-06-08
Release date:2017-10-11
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Nature, 550, 2017
5WJ9
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BU of 5wj9 by Molmil
Human TRPML1 channel structure in agonist-bound open conformation
Descriptor: 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1
Authors:Schmiege, P, Li, X.
Deposit date:2017-07-21
Release date:2017-10-18
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Human TRPML1 channel structures in open and closed conformations.
Nature, 550, 2017
5WPT
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BU of 5wpt by Molmil
Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION
Authors:Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
6D1W
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BU of 6d1w by Molmil
human PKD2 F604P mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E.
Deposit date:2018-04-12
Release date:2018-06-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
6DU8
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BU of 6du8 by Molmil
Human Polycsytin 2-l1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystic kidney disease 2-like 1 protein
Authors:Hulse, R.E, Clapham, D.E, Li, Z, Huang, R.K, Zhang, J.
Deposit date:2018-06-20
Release date:2018-07-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Cryo-EM structure of the polycystin 2-l1 ion channel.
Elife, 7, 2018
6E7P
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BU of 6e7p by Molmil
cryo-EM structure of human TRPML1 with PI35P2
Descriptor: (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], Mucolipin-1
Authors:Schmiege, P, Li, X.
Deposit date:2018-07-27
Release date:2018-11-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6E7Y
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BU of 6e7y by Molmil
cryo-EM structure of human TRPML1 with PI45P2
Descriptor: Mucolipin-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Schmiege, P, Li, X.
Deposit date:2018-07-27
Release date:2018-11-28
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6E7Z
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BU of 6e7z by Molmil
cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2
Descriptor: (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1
Authors:Schmiege, P, Li, X.
Deposit date:2018-07-27
Release date:2018-11-28
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
5WJ5
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BU of 5wj5 by Molmil
Human TRPML1 channel structure in closed conformation
Descriptor: Mucolipin-1
Authors:Schmiege, P, Li, X.
Deposit date:2017-07-21
Release date:2017-10-18
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Human TRPML1 channel structures in open and closed conformations.
Nature, 550, 2017
5WPV
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BU of 5wpv by Molmil
Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION
Authors:Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017

 

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數據於2024-03-27公開中

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