7OUN
| |
4WHD
| Human CEACAM1 N-domain homodimer | Descriptor: | Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, octyl beta-D-glucopyranoside | Authors: | Kirouac, K.N, Prive, G.G. | Deposit date: | 2014-09-22 | Release date: | 2015-10-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Human CEACAM1 N-domain homodimer To Be Published
|
|
4WHC
| Human CEACAM6 N-domain | Descriptor: | Carcinoembryonic antigen-related cell adhesion molecule 6, ZINC ION | Authors: | Prive, G.G, Kirouac, K.N. | Deposit date: | 2014-09-22 | Release date: | 2015-10-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | Human CEACAM6 N-domain To Be Published
|
|
4WEN
| Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain antibody V2 | Descriptor: | Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AC | Authors: | Moonens, K, Van den Broeck, I, Pardon, E, De Kerpel, M, Remaut, H, De Greve, H. | Deposit date: | 2014-09-10 | Release date: | 2015-02-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies. Vet. Res., 46, 2015
|
|
4WEM
| Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain antibody V1 | Descriptor: | Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AC, PHOSPHATE ION | Authors: | Moonens, K, Van den Broeck, I, Pardon, E, De Kerpel, M, Remaut, H, De Greve, H. | Deposit date: | 2014-09-10 | Release date: | 2015-02-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies. Vet. Res., 46, 2015
|
|
4WEU
| Co-complex structure of the F4 fimbrial adhesin FaeG variant ad with llama single domain antibody V3 | Descriptor: | Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AD | Authors: | Moonens, K, Van den Broeck, I, Pardon, E, De Kerpel, M, Remaut, H, De Greve, H. | Deposit date: | 2014-09-11 | Release date: | 2015-02-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies. Vet. Res., 46, 2015
|
|
5O4Y
| Structure of human PD-L1 in complex with inhibitor | Descriptor: | PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2, Programmed cell death 1 ligand 1 | Authors: | Magiera, K, Grudnik, P, Dubin, G, Holak, T.A. | Deposit date: | 2017-05-31 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5O45
| Structure of human PD-L1 in complex with inhibitor | Descriptor: | PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2, Programmed cell death 1 ligand 1 | Authors: | Magiera, K, Grudnik, P, Dubin, G, Holak, T.A. | Deposit date: | 2017-05-26 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5OWP
| Crystal structure of glycopeptide "GVTSAfPDT*RPAP" in complex with scFv-SM3 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, ... | Authors: | Bermejo, I.A, Albuquerque, I.S, Somovilla, V.J, Martinez-Saez, N, Castro-Lopez, J, Garcia-Martin, F, Hinou, H, Nishimura, S, Jimenez-Barbero, J, Asensio, J.L, Avenoza, A, Busto, J.H, Hurtado-Guerrero, R, Peregrina, J.M, Bernardes, G.J, Corzana, F. | Deposit date: | 2017-09-02 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer. J. Am. Chem. Soc., 139, 2017
|
|
6YYE
| TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TREM2 Single chain variable 2, Triggering receptor expressed on myeloid cells 2 | Authors: | Szykowska, A, Preger, C, Krojer, T, Mukhopadhyay, S.M.M, McKinley, G, Graslund, S, Wigren, E, Persson, H, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Di Daniel, E, Burgess-Brown, N, Bullock, A. | Deposit date: | 2020-05-04 | Release date: | 2021-02-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure, 29, 2021
|
|
6Z1I
| |
6Z1O
| |
7AH1
| L19 diabody fragment from immunocytokine L19-IL2 | Descriptor: | Anti-(ED-B) scFV | Authors: | Ongaro, T, Guarino, S.R, Scietti, L, Palamini, M, Wulhfard, S, Villa, A, Neri, D, Forneris, F. | Deposit date: | 2020-09-23 | Release date: | 2021-02-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Inference of molecular structure for characterization and improvement of clinical grade immunocytokines. J.Struct.Biol., 213, 2021
|
|
7BXA
| Crystal structure of PD-1 in complex with tislelizumab Fab | Descriptor: | Programmed cell death protein 1, heavy chain, light chain | Authors: | Heo, Y.S, Lee, S.H, Lim, H, Lee, H.T, Kim, Y.J, Park, E.B. | Deposit date: | 2020-04-18 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy. Biochem.Biophys.Res.Commun., 527, 2020
|
|
7BEA
| Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | Descriptor: | 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. | Deposit date: | 2020-12-22 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12, 2021
|
|
1BFV
| MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI | Descriptor: | ESTRIOL 3-(B-D-GLUCURONIDE), FV4155, ZINC ION | Authors: | Trinh, C.H, Phillips, S.E.V. | Deposit date: | 1997-05-27 | Release date: | 1997-12-03 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity. Structure, 5, 1997
|
|
8TE6
| |
8TE5
| |
7KPG
| Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Heavy chain of Fab 25 anti-SIRP-alpha antibody, Light chain of Fab 25 anti-SIRP-alpha antibody, SULFATE ION, ... | Authors: | Sim, J, Pons, J. | Deposit date: | 2020-11-11 | Release date: | 2020-12-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Targeting the myeloid checkpoint receptor SIRP alpha potentiates innate and adaptive immune responses to promote anti-tumor activity. J Hematol Oncol, 13, 2020
|
|
8SZY
| |
1BWW
| BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT | Descriptor: | PROTEIN (IG KAPPA CHAIN V-I REGION REI) | Authors: | Uson, I, Pohl, E, Schneider, T.R, Dauter, Z, Schmidt, A, Fritz, H.J, Sheldrick, G.M. | Deposit date: | 1998-09-29 | Release date: | 1998-10-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 1.7 A structure of the stabilized REIv mutant T39K. Application of local NCS restraints. Acta Crystallogr.,Sect.D, 55, 1999
|
|
1BWM
| A SINGLE-CHAIN T CELL RECEPTOR | Descriptor: | PROTEIN (ALPHA-BETA T CELL RECEPTOR (TCR) (D10)) | Authors: | Hare, B.J, Wyss, D.F, Reinherz, E.L, Wagner, G. | Deposit date: | 1998-09-23 | Release date: | 1999-07-22 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat.Struct.Biol., 6, 1999
|
|
1CD0
| STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO | Descriptor: | PROTEIN (JTO, A VARIABLE DOMAIN FROM LAMBDA-6 TYPE IMMUNOGLOBULIN LIGHT CHAIN) | Authors: | Pokkuluri, P.R, Solomon, A, Weiss, D.T, Stevens, F.J, Schiffer, M. | Deposit date: | 1999-03-05 | Release date: | 2000-03-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Tertiary structure of human lambda 6 light chains. Amyloid, 6, 1999
|
|
1CDC
| CD2, N-TERMINAL DOMAIN (1-99), TRUNCATED FORM | Descriptor: | CD2 | Authors: | Murray, A.J, Barclay, A.N, Brady, R.L. | Deposit date: | 1995-05-23 | Release date: | 1995-09-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | One sequence, two folds: a metastable structure of CD2. Proc.Natl.Acad.Sci.USA, 92, 1995
|
|
7KQL
| Anti-Tim3 antibody Fab complex | Descriptor: | GLYCEROL, Hepatitis A virus cellular receptor 2, Tim3.18 Fab heavy chain, ... | Authors: | Deng, X.A, West, S.M, Strop, P. | Deposit date: | 2020-11-16 | Release date: | 2022-02-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Tim-3 mediates T cell trogocytosis to limit antitumor immunity. J.Clin.Invest., 132, 2022
|
|