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7OUN
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BU of 7oun by Molmil
Structure of human PD-L1 in complex with macrocyclic inhibitor
Descriptor: Programmed cell death 1 ligand 1, macrocyclic peptide
Authors:Zyla, E, Dubin, G.
Deposit date:2021-06-12
Release date:2021-09-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis.
Molecules, 26, 2021
4WHD
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BU of 4whd by Molmil
Human CEACAM1 N-domain homodimer
Descriptor: Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, octyl beta-D-glucopyranoside
Authors:Kirouac, K.N, Prive, G.G.
Deposit date:2014-09-22
Release date:2015-10-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human CEACAM1 N-domain homodimer
To Be Published
4WHC
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BU of 4whc by Molmil
Human CEACAM6 N-domain
Descriptor: Carcinoembryonic antigen-related cell adhesion molecule 6, ZINC ION
Authors:Prive, G.G, Kirouac, K.N.
Deposit date:2014-09-22
Release date:2015-10-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.705 Å)
Cite:Human CEACAM6 N-domain
To Be Published
4WEN
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BU of 4wen by Molmil
Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain antibody V2
Descriptor: Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AC
Authors:Moonens, K, Van den Broeck, I, Pardon, E, De Kerpel, M, Remaut, H, De Greve, H.
Deposit date:2014-09-10
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.
Vet. Res., 46, 2015
4WEM
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BU of 4wem by Molmil
Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain antibody V1
Descriptor: Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AC, PHOSPHATE ION
Authors:Moonens, K, Van den Broeck, I, Pardon, E, De Kerpel, M, Remaut, H, De Greve, H.
Deposit date:2014-09-10
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.
Vet. Res., 46, 2015
4WEU
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BU of 4weu by Molmil
Co-complex structure of the F4 fimbrial adhesin FaeG variant ad with llama single domain antibody V3
Descriptor: Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AD
Authors:Moonens, K, Van den Broeck, I, Pardon, E, De Kerpel, M, Remaut, H, De Greve, H.
Deposit date:2014-09-11
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.
Vet. Res., 46, 2015
5O4Y
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BU of 5o4y by Molmil
Structure of human PD-L1 in complex with inhibitor
Descriptor: PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2, Programmed cell death 1 ligand 1
Authors:Magiera, K, Grudnik, P, Dubin, G, Holak, T.A.
Deposit date:2017-05-31
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O45
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BU of 5o45 by Molmil
Structure of human PD-L1 in complex with inhibitor
Descriptor: PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2, Programmed cell death 1 ligand 1
Authors:Magiera, K, Grudnik, P, Dubin, G, Holak, T.A.
Deposit date:2017-05-26
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OWP
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BU of 5owp by Molmil
Crystal structure of glycopeptide "GVTSAfPDT*RPAP" in complex with scFv-SM3
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, ...
Authors:Bermejo, I.A, Albuquerque, I.S, Somovilla, V.J, Martinez-Saez, N, Castro-Lopez, J, Garcia-Martin, F, Hinou, H, Nishimura, S, Jimenez-Barbero, J, Asensio, J.L, Avenoza, A, Busto, J.H, Hurtado-Guerrero, R, Peregrina, J.M, Bernardes, G.J, Corzana, F.
Deposit date:2017-09-02
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.
J. Am. Chem. Soc., 139, 2017
6YYE
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BU of 6yye by Molmil
TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, TREM2 Single chain variable 2, Triggering receptor expressed on myeloid cells 2
Authors:Szykowska, A, Preger, C, Krojer, T, Mukhopadhyay, S.M.M, McKinley, G, Graslund, S, Wigren, E, Persson, H, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Di Daniel, E, Burgess-Brown, N, Bullock, A.
Deposit date:2020-05-04
Release date:2021-02-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.
Structure, 29, 2021
6Z1I
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BU of 6z1i by Molmil
AL amyloid fibril from a lambda 3 light chain in conformation B
Descriptor: lambda 3 light chain fragment, residues 2-116
Authors:Radamaker, L, Fandrich, M.
Deposit date:2020-05-13
Release date:2021-02-24
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis.
Nat Commun, 12, 2021
6Z1O
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BU of 6z1o by Molmil
AL amyloid fibril from a lambda 3 light chain in conformation A
Descriptor: lambda 3 immunoglobulin light chain fragment, residues 2-116
Authors:Radamaker, L, Fandrich, M.
Deposit date:2020-05-14
Release date:2021-02-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis.
Nat Commun, 12, 2021
7AH1
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BU of 7ah1 by Molmil
L19 diabody fragment from immunocytokine L19-IL2
Descriptor: Anti-(ED-B) scFV
Authors:Ongaro, T, Guarino, S.R, Scietti, L, Palamini, M, Wulhfard, S, Villa, A, Neri, D, Forneris, F.
Deposit date:2020-09-23
Release date:2021-02-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inference of molecular structure for characterization and improvement of clinical grade immunocytokines.
J.Struct.Biol., 213, 2021
7BXA
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BU of 7bxa by Molmil
Crystal structure of PD-1 in complex with tislelizumab Fab
Descriptor: Programmed cell death protein 1, heavy chain, light chain
Authors:Heo, Y.S, Lee, S.H, Lim, H, Lee, H.T, Kim, Y.J, Park, E.B.
Deposit date:2020-04-18
Release date:2020-06-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy.
Biochem.Biophys.Res.Commun., 527, 2020
7BEA
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BU of 7bea by Molmil
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor
Descriptor: 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1
Authors:Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A.
Deposit date:2020-12-22
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.
Acs Med.Chem.Lett., 12, 2021
1BFV
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BU of 1bfv by Molmil
MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI
Descriptor: ESTRIOL 3-(B-D-GLUCURONIDE), FV4155, ZINC ION
Authors:Trinh, C.H, Phillips, S.E.V.
Deposit date:1997-05-27
Release date:1997-12-03
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity.
Structure, 5, 1997
8TE6
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BU of 8te6 by Molmil
Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
Descriptor: V-set and immunoglobulin domain-containing protein 4
Authors:Abram, T.G, Geisbrecht, B.V.
Deposit date:2023-07-05
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.251 Å)
Cite:New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants.
Immunohorizons, 7, 2023
8TE5
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BU of 8te5 by Molmil
Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
Descriptor: V-set and immunoglobulin domain-containing protein 4
Authors:Abram, T.G, Geisbrecht, B.V.
Deposit date:2023-07-05
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants.
Immunohorizons, 7, 2023
7KPG
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BU of 7kpg by Molmil
Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Descriptor: Heavy chain of Fab 25 anti-SIRP-alpha antibody, Light chain of Fab 25 anti-SIRP-alpha antibody, SULFATE ION, ...
Authors:Sim, J, Pons, J.
Deposit date:2020-11-11
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Targeting the myeloid checkpoint receptor SIRP alpha potentiates innate and adaptive immune responses to promote anti-tumor activity.
J Hematol Oncol, 13, 2020
8SZY
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BU of 8szy by Molmil
Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BMS-986207 Fab Heavy Chain, BMS-986207 light chain, ...
Authors:Diong, S.J, Lee, P.S.
Deposit date:2023-05-30
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT.
Mabs, 15, 2023
1BWW
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BU of 1bww by Molmil
BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT
Descriptor: PROTEIN (IG KAPPA CHAIN V-I REGION REI)
Authors:Uson, I, Pohl, E, Schneider, T.R, Dauter, Z, Schmidt, A, Fritz, H.J, Sheldrick, G.M.
Deposit date:1998-09-29
Release date:1998-10-07
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:1.7 A structure of the stabilized REIv mutant T39K. Application of local NCS restraints.
Acta Crystallogr.,Sect.D, 55, 1999
1BWM
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BU of 1bwm by Molmil
A SINGLE-CHAIN T CELL RECEPTOR
Descriptor: PROTEIN (ALPHA-BETA T CELL RECEPTOR (TCR) (D10))
Authors:Hare, B.J, Wyss, D.F, Reinherz, E.L, Wagner, G.
Deposit date:1998-09-23
Release date:1999-07-22
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.
Nat.Struct.Biol., 6, 1999
1CD0
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BU of 1cd0 by Molmil
STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO
Descriptor: PROTEIN (JTO, A VARIABLE DOMAIN FROM LAMBDA-6 TYPE IMMUNOGLOBULIN LIGHT CHAIN)
Authors:Pokkuluri, P.R, Solomon, A, Weiss, D.T, Stevens, F.J, Schiffer, M.
Deposit date:1999-03-05
Release date:2000-03-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Tertiary structure of human lambda 6 light chains.
Amyloid, 6, 1999
1CDC
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BU of 1cdc by Molmil
CD2, N-TERMINAL DOMAIN (1-99), TRUNCATED FORM
Descriptor: CD2
Authors:Murray, A.J, Barclay, A.N, Brady, R.L.
Deposit date:1995-05-23
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:One sequence, two folds: a metastable structure of CD2.
Proc.Natl.Acad.Sci.USA, 92, 1995
7KQL
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BU of 7kql by Molmil
Anti-Tim3 antibody Fab complex
Descriptor: GLYCEROL, Hepatitis A virus cellular receptor 2, Tim3.18 Fab heavy chain, ...
Authors:Deng, X.A, West, S.M, Strop, P.
Deposit date:2020-11-16
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Tim-3 mediates T cell trogocytosis to limit antitumor immunity.
J.Clin.Invest., 132, 2022

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數據於2024-03-27公開中

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