5MWW
 
 | | Sigma1.1 domain of sigmaA from Bacillus subtilis | | Descriptor: | RNA polymerase sigma factor SigA | | Authors: | Zachrdla, M, Padrta, P, Rabatinova, A, Sanderova, H, Barvik, I, Krasny, L, Zidek, L. | | Deposit date: | 2017-01-20 | | Release date: | 2017-06-14 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Solution structure of domain 1.1 of the sigma (A) factor from Bacillus subtilis is preformed for binding to the RNA polymerase core.
J. Biol. Chem., 292, 2017
|
|
2K6X
 | | Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1- Induced Compacted Structure | | Descriptor: | RNA polymerase sigma factor rpoD | | Authors: | Schwartz, E.C, Shekhtman, A, Dutta, K, Pratt, M.R, Cowburn, D, Darst, S, Muir, T.W. | | Deposit date: | 2008-07-28 | | Release date: | 2008-10-28 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1 - Induced Compacted Structure
Chem.Biol., 15, 2008
|
|
8U3B
 | | Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A | | Descriptor: | DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Liu, B, Kompaniiets, D, Wang, D. | | Deposit date: | 2023-09-07 | | Release date: | 2024-01-17 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structural basis for transcription activation by the nitrate-responsive regulator NarL.
Nucleic Acids Res., 52, 2024
|
|
3IYD
 | | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, DNA (98-MER), ... | | Authors: | Hudson, B.P, Quispe, J, Lara, S, Kim, Y, Berman, H, Arnold, E, Ebright, R.H, Lawson, C.L. | | Deposit date: | 2009-08-01 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (19.799999 Å) | | Cite: | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
8FTD
 | | Structure of Escherichia coli CedA in complex with transcription initiation complex | | Descriptor: | CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Liu, M, Vassyliev, N, Nudler, E. | | Deposit date: | 2023-01-11 | | Release date: | 2024-01-10 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | General transcription factor from Escherichia coli with a distinct mechanism of action.
Nat.Struct.Mol.Biol., 31, 2024
|
|
4MEX
 | | Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. | | Deposit date: | 2013-08-27 | | Release date: | 2014-05-21 | | Last modified: | 2014-06-25 | | Method: | X-RAY DIFFRACTION (3.902 Å) | | Cite: | Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
|
|
4MEY
 | | Crystal structure of Escherichia coli RNA polymerase holoenzyme | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. | | Deposit date: | 2013-08-27 | | Release date: | 2014-05-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.948 Å) | | Cite: | Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
|
|
8IGS
 | | Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. | | Deposit date: | 2023-02-21 | | Release date: | 2023-05-17 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of lambda CII-dependent transcription activation.
Structure, 31, 2023
|
|
8IGR
 | | Cryo-EM structure of CII-dependent transcription activation complex | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. | | Deposit date: | 2023-02-21 | | Release date: | 2023-05-17 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of lambda CII-dependent transcription activation.
Structure, 31, 2023
|
|
8JO2
 | | Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA | | Descriptor: | DNA (65-MER), DNA-binding transcriptional regulator BasR, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Lou, Y.-C, Huang, H.-Y, Chen, C, Wu, K.-P. | | Deposit date: | 2023-06-06 | | Release date: | 2023-08-30 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA.
Nucleic Acids Res., 51, 2023
|
|
6VJS
 | | Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex | | Descriptor: | 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Murakami, K.S, Molodtsov, V. | | Deposit date: | 2020-01-17 | | Release date: | 2020-10-07 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (4.02 Å) | | Cite: | Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice.
Acs Infect Dis., 6, 2020
|
|
7SZK
 | | Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex | | Descriptor: | (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Shin, Y, Murakami, K.S. | | Deposit date: | 2021-11-28 | | Release date: | 2022-07-13 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
|
|
7SZJ
 | |
6WMT
 | | F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex | | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | Deposit date: | 2020-04-21 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.43 Å) | | Cite: | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
7UBM
 | |
7UBN
 | |
6WMU
 | | E. coli RNAPs70-SspA-gadA DNA complex | | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | Deposit date: | 2020-04-21 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
6WMR
 | | F. tularensis RNAPs70-(MglA-SspA)-iglA DNA complex | | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | Deposit date: | 2020-04-21 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
7F75
 | | Cryo-EM structure of Spx-dependent transcription activation complex | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Lin, W, Feng, Y, Shi, J. | | Deposit date: | 2021-06-28 | | Release date: | 2021-10-13 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural basis of transcription activation by the global regulator Spx.
Nucleic Acids Res., 49, 2021
|
|
6B6H
 | | The cryo-EM structure of a bacterial class I transcription activation complex | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. | | Deposit date: | 2017-10-02 | | Release date: | 2017-11-15 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of bacterial transcription activation.
Science, 358, 2017
|
|
7KHE
 | | Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp | | Descriptor: | CHAPSO, DNA (46-MER), DNA (54-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-21 | | Release date: | 2020-12-09 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
|
|
7KHB
 | | Escherichia coli RNA polymerase and rrnBP1 promoter open complex | | Descriptor: | CHAPSO, DNA (60-MER), DNA (64-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-20 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
|
|
7KHC
 | | Escherichia coli RNA polymerase and rrnBP1 promoter closed complex | | Descriptor: | CHAPSO, DNA (18 MER), DNA (63-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-20 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
|
|
7KHI
 | | Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp | | Descriptor: | CHAPSO, DNA (28-MER), DNA (36-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-21 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
|
|
6C9Y
 | | Cryo-EM structure of E. coli RNAP sigma70 holoenzyme | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yenool, D, Jiang, W, Murakami, K.S. | | Deposit date: | 2018-01-29 | | Release date: | 2018-02-28 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018
|
|
