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5H3C
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Crystal structure of Arabidopsis SNC1 TIR domain
Descriptor: Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
Authors:Hyun, K.G, Yoon, J.M, Song, J.J.
Deposit date:2016-10-22
Release date:2016-12-07
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Crystal structure of Arabidopsis thaliana SNC1 TIR domain
Biochem.Biophys.Res.Commun., 481, 2016
1T3G
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Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL
Descriptor: X-linked interleukin-1 receptor accessory protein-like 1
Authors:Khan, J.A, Tong, L.
Deposit date:2004-04-26
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
J.Biol.Chem., 279, 2004
5KU7
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Crystal structure of the TIR domain from the Muscadinia rotundifolia disease resistance protein RPV1
Descriptor: MALONIC ACID, TIR-NB-LRR type resistance protein RPV1
Authors:Williams, S.J, Ericsson, D.J, Kobe, B.
Deposit date:2016-07-12
Release date:2017-02-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of the TIR Domain from the Grape NLR Protein RPV1.
Front Plant Sci, 7, 2016
1O77
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CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2
Descriptor: TOLL-LIKE RECEPTOR 2
Authors:Tao, X, Xu, Y, Ye, Z, Beg, A.A, Tong, L.
Deposit date:2002-10-24
Release date:2002-11-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An Extensively Associated Dimer in the Structure of the C713S Mutant of the Tir Domain of Human Tlr2
Biochem.Biophys.Res.Commun., 299, 2002
3OZI
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BU of 3ozi by Molmil
Crystal structure of the TIR domain from the flax disease resistance protein L6
Descriptor: COBALT (II) ION, L6tr
Authors:Ve, T, Bernoux, M, Williams, S, Valkov, E, Warren, C, Hatters, D, Ellis, J.G, Dodds, P.N, Kobe, B.
Deposit date:2010-09-25
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation.
Cell Host Microbe, 9, 2011
6O0W
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Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-2'-5'-DIPHOSPHATE, TIR-NB-LRR type resistance protein RUN1
Authors:Horsefield, S, Burdett, H, Zhang, X, Manik, M.K, Shi, Y, Chen, J, Tiancong, Q, Gilley, J, Lai, J, Gu, W, Rank, M, Casey, L, Ericsson, D.J, Foley, G, Hughes, R.O, Bosanac, T, von Itzstein, M, Rathjen, J.P, Nanson, J.D, Boden, M, Dry, I.B, Williams, S.J, Staskawicz, B.J, Coleman, M.P, Ve, T, Dodds, P.N, Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
4OM7
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Crystal structure of TIR domain of TLR6
Descriptor: Toll-like receptor 6
Authors:Park, H.H, Jang, T.H.
Deposit date:2014-01-26
Release date:2014-08-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR-TIR Interaction for Toll-Like Receptor Signaling Pathway.
J.Mol.Biol., 426, 2014
2J67
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The TIR domain of human Toll-Like Receptor 10 (TLR10)
Descriptor: TOLL LIKE RECEPTOR 10
Authors:Stenmark, P, Ogg, D, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Johansson, I, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson, M.E, Nilsson-Ehle, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Welin, M, Nordlund, P.
Deposit date:2006-09-26
Release date:2006-09-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Crystal Structure of the Human Toll-Like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer.
J.Biol.Chem., 283, 2008
5TEC
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Crystal structure of the TIR domain from the Arabidopsis thaliana NLR protein SNC1
Descriptor: Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
Authors:Zhang, X, Bentham, A, Ve, T, Williams, S.J, Kobe, B.
Deposit date:2016-09-20
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TEB
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Crystal Structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPP1
Descriptor: Recognition of Peronospora parasitica 1
Authors:Bentham, A.R, Zhang, X, Croll, T, Williams, S, Kobe, B.
Deposit date:2016-09-20
Release date:2017-02-01
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4C6T
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Crystal structure of the RPS4 and RRS1 TIR domain heterodimer
Descriptor: DISEASE RESISTANCE PROTEIN RPS4, MALONIC ACID, PROBABLE WRKY TRANSCRIPTION FACTOR 52
Authors:Williams, S.J, Sohn, K.H, Wan, L, Bernoux, M, Ma, Y, Segonzac, C, Ve, T, Sarris, P, Ericsson, D.J, Saucet, S.B, Zhang, X, Parker, J, Dodds, P.N, Jones, J.D.G, Kobe, B.
Deposit date:2013-09-19
Release date:2014-05-28
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
4C6R
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Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPS4
Descriptor: DISEASE RESISTANCE PROTEIN RPS4
Authors:Williams, S.J, Sohn, K.H, Wan, L, Bernoux, M, Ma, Y, Segonzac, C, Ve, T, Sarris, P, Ericsson, D.J, Saucet, S.B, Zhang, X, Parker, J, Dodds, P.N, Jones, J.D.G, Kobe, B.
Deposit date:2013-09-19
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
3JRN
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BU of 3jrn by Molmil
Crystal structure of TIR domain from Arabidopsis Thaliana
Descriptor: ARSENIC, AT1G72930 protein
Authors:Chan, S.L, Mukasa, T, Santelli, E, Low, L.Y, Pascual, J.
Deposit date:2009-09-08
Release date:2009-10-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants.
Protein Sci., 19, 2009
7NT7
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BU of 7nt7 by Molmil
Solution structure of toll like receptor 1 (TLR1) TIR domain
Descriptor: Toll-like receptor 1
Authors:Mineev, K.S, Lushpa, V.A, Goncharuk, M.V.
Deposit date:2021-03-09
Release date:2021-08-25
Last modified:2021-10-13
Method:SOLUTION NMR
Cite:Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn 2+ ions.
Commun Biol, 4, 2021
7NUX
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BU of 7nux by Molmil
Crystal structure of the TIR domain of human TLR1 (crystallised without ZN2+ ions)
Descriptor: Toll-like receptor 1
Authors:Vakhrameev, D.D, Luginina, A.P, Shevtsov, M.B, Lushpa, V.A, Mineev, K.S, Borshchevskiy, V.I.
Deposit date:2021-03-15
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn 2+ ions.
Commun Biol, 4, 2021
7NUW
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BU of 7nuw by Molmil
Crystal structure of the TIR domain of human TLR1 (crystallised with Zn2+ ions)
Descriptor: Toll-like receptor 1
Authors:Vakhrameev, D.D, Luginina, A.P, Shevtsov, M.B, Lushpa, V.A, Mineev, K.S, Borshchevskiy, V.I.
Deposit date:2021-03-15
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn 2+ ions.
Commun Biol, 4, 2021
1FYV
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BU of 1fyv by Molmil
CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1
Descriptor: TOLL-LIKE RECEPTOR 1
Authors:Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L.
Deposit date:2000-10-03
Release date:2000-11-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408, 2000
1FYX
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BU of 1fyx by Molmil
CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2
Descriptor: TOLL-LIKE RECEPTOR 2
Authors:Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L.
Deposit date:2000-10-03
Release date:2000-11-22
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408, 2000
1FYW
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BU of 1fyw by Molmil
CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2
Descriptor: TOLL-LIKE RECEPTOR 2
Authors:Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-10-03
Release date:2000-11-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408, 2000
7S2Z
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BU of 7s2z by Molmil
Crystal structure of the E100A mutant TIR domain from the grapevine disease resistance protein RUN1 bound to NAD
Descriptor: Disease resistance protein RUN1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Burdett, H, Kobe, B.
Deposit date:2021-09-04
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Self-association configures the NAD + -binding site of plant NLR TIR domains
Biorxiv, 2021
7RTS
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BU of 7rts by Molmil
Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 without the AE interface
Descriptor: Disease resistance protein RUN1, SULFATE ION
Authors:Burdett, H, Kobe, B.
Deposit date:2021-08-15
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Self-association configures the NAD + -binding site of plant NLR TIR domains
Biorxiv, 2021
7RX1
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BU of 7rx1 by Molmil
Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1
Descriptor: Disease resistance protein RUN1, SULFATE ION
Authors:Burdett, H, Kobe, B.
Deposit date:2021-08-21
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Self-association configures the NAD + -binding site of plant NLR TIR domains
Biorxiv, 2021
7SZL
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BU of 7szl by Molmil
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)
Descriptor: X-linked interleukin-1 receptor accessory protein-like 2
Authors:Nimma, S, Gu, W, Manik, M.K, Ve, T, Nanson, J.D, Kobe, B.
Deposit date:2021-11-28
Release date:2022-02-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signalling.
Febs Lett., 596, 2022
7VU8
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L7-Tir domain with bound ligand
Descriptor: 2',3'- cyclic AMP, Flax rust resistance protein
Authors:Tan, Y, Xu, C, Yu, D, Song, W, Wu, B, Schulze-Lefert, P, Chai, J.
Deposit date:2021-11-01
Release date:2022-06-01
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.
Cell, 185, 2022
7X5L
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Tir-dsDNA complex, the initial binding state
Descriptor: DNA (5'-D(*AP*TP*AP*AP*AP*TP*TP*A)-3'), DNA (5'-D(*TP*TP*AP*AP*TP*TP*AP*A)-3'), Flax rust resistance protein
Authors:Tan, Y, Xu, C, Yu, D, Song, W, Wu, B, Schulze-Lefert, P, Chai, J.
Deposit date:2022-03-04
Release date:2022-06-01
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.
Cell, 185, 2022

 

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數據於2024-03-27公開中

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