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1BY1
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BU of 1by1 by Molmil
DBL homology domain from beta-PIX
Descriptor: PROTEIN (PIX)
Authors:Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K.
Deposit date:1998-10-22
Release date:1999-10-24
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
5N7E
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BU of 5n7e by Molmil
Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).
Descriptor: Breakpoint cluster region protein, Mb(Bcr-DH_4)
Authors:Reckel, S, Reynaud, A, Pojer, F, Hantschel, O.
Deposit date:2017-02-20
Release date:2017-12-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.647 Å)
Cite:Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
2KR9
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BU of 2kr9 by Molmil
Kalirin DH1 NMR structure
Descriptor: Kalirin
Authors:Gorbatyuk, V.Y, Schiller, M.R, Hoch, J.C.
Deposit date:2009-12-10
Release date:2010-12-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The solution NMR structure of the first Dbl domain of RhoGEF Kalirin.
To be Published
8C7D
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BU of 8c7d by Molmil
Structure of the GEF Kalirin DH2 Domain
Descriptor: Kalirin
Authors:Callens, M.C, Thompson, A.P, Gray, J.L, Bountra, C, von Delft, F, Brennan, P.E.
Deposit date:2023-01-14
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure-based alignment and analysis of RHO selectivity of RHO-DBL GTPase exchange factors
to be published
4D0O
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BU of 4d0o by Molmil
AKAP13 (AKAP-Lbc) DH domain
Descriptor: A-KINASE ANCHOR PROTEIN 13
Authors:Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
3EO2
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BU of 3eo2 by Molmil
Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
Descriptor: Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-09-26
Release date:2008-10-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
To be Published
1F5X
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BU of 1f5x by Molmil
NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN
Descriptor: RHO-GEF VAV
Authors:Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y.
Deposit date:2000-06-18
Release date:2000-09-15
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell(Cambridge,Mass.), 102, 2000
4GYV
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BU of 4gyv by Molmil
Crystal structure of the DH domain of FARP2
Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X, Zhang, X.
Deposit date:2012-09-05
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
5N6R
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BU of 5n6r by Molmil
Solution structure of the Dbl-homology domain of Bcr-Abl
Descriptor: Breakpoint cluster region protein
Authors:Reckel, S, Lohr, F, Buchner, L, Guntert, P, Dotsch, V, Hantschel, O.
Deposit date:2017-02-16
Release date:2017-12-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
5HZI
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BU of 5hzi by Molmil
Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain
Descriptor: FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1
Authors:Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I.
Deposit date:2016-02-02
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
5HZJ
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BU of 5hzj by Molmil
Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain
Descriptor: FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1
Authors:Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I.
Deposit date:2016-02-02
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
5HZK
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BU of 5hzk by Molmil
Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with Cdc42
Descriptor: Cell division control protein 42 homolog, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I.
Deposit date:2016-02-02
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
1TXD
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BU of 1txd by Molmil
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Descriptor: Rho guanine nucleotide exchange factor 12
Authors:Kristelly, R, Gao, G, Tesmer, J.J.
Deposit date:2004-07-03
Release date:2004-09-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
3GF9
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BU of 3gf9 by Molmil
Crystal structure of human Intersectin 2 RhoGEF domain
Descriptor: Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y, Tong, Y, Tempel, W, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-02-26
Release date:2009-03-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
3ODX
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BU of 3odx by Molmil
Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF
Descriptor: Rho guanine nucleotide exchange factor 1
Authors:Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C.
Deposit date:2010-08-12
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODO
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BU of 3odo by Molmil
Crystal Structure of the DH/PH Domains of p115-RhoGEF
Descriptor: Rho guanine nucleotide exchange factor 1
Authors:Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C.
Deposit date:2010-08-11
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODW
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BU of 3odw by Molmil
Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF
Descriptor: Rho guanine nucleotide exchange factor 1
Authors:Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C.
Deposit date:2010-08-11
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3P6A
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BU of 3p6a by Molmil
Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)
Descriptor: Rho guanine nucleotide exchange factor 1
Authors:Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C.
Deposit date:2010-10-11
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
6PCV
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BU of 6pcv by Molmil
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1
Authors:Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G.
Deposit date:2019-06-18
Release date:2019-10-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
6D8Z
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BU of 6d8z by Molmil
Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio
Descriptor: Triple functional domain protein
Authors:Bandekar, S, Tesmer, J.J.
Deposit date:2018-04-27
Release date:2019-02-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.
Sci Signal, 12, 2019
3T06
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BU of 3t06 by Molmil
Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA
Descriptor: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA
Authors:Bielnicki, J.A, Derewenda, U, Derewenda, Z.S.
Deposit date:2011-07-19
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF.
J.Biol.Chem., 286, 2011
4XH9
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BU of 4xh9 by Molmil
CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1
Descriptor: Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA
Authors:Garcia, C, Petit, P, Boutin, J.A, Ferry, G, Vuillard, L.
Deposit date:2015-01-05
Release date:2015-01-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot.
J. Biol. Chem., 293, 2018
2VRW
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BU of 2vrw by Molmil
Critical structural role for the PH and C1 domains of the Vav1 exchange factor
Descriptor: PROTO-ONCOGENE VAV, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, ZINC ION
Authors:Rapley, J, Tybulewicz, V, Rittinger, K.
Deposit date:2008-04-16
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.
Embo Rep., 9, 2008
3BJI
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BU of 3bji by Molmil
Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1
Descriptor: Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION
Authors:Chrencik, J.E, Brooun, A, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-04
Release date:2008-07-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
J.Mol.Biol., 380, 2008
1NTY
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BU of 1nty by Molmil
Crystal structure of the first DH/PH domain of Trio to 1.7 A
Descriptor: Triple functional domain protein
Authors:Skowronek, K.R, Zheng, Y, Nassar, N.
Deposit date:2003-01-30
Release date:2004-06-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids.
J.Biol.Chem., 279, 2004

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數據於2024-03-27公開中

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