7RCP
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8CUA
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8CV2
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7AHK
| Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, GLYCEROL, ... | Authors: | Kovalev, K, Alleva, C, Astashkin, A, Machtens, J.-P, Fahlke, C, Gordeliy, V. | Deposit date: | 2020-09-24 | Release date: | 2020-11-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Na + -dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters. Sci Adv, 6, 2020
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8CUI
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7UG0
| TBOA-bound GltPh RSMR mutant in IFS state | Descriptor: | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | Authors: | Huang, Y, Boudker, O. | Deposit date: | 2022-03-23 | Release date: | 2023-03-29 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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5DWY
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7VR7
| Inward-facing structure of human EAAT2 in the WAY213613-bound state | Descriptor: | (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Kato, T, Kusakizako, T, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2021-10-22 | Release date: | 2022-08-10 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2. Nat Commun, 13, 2022
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6R7R
| Crystal structure of the glutamate transporter homologue GltTk in complex with D-aspartate | Descriptor: | D-ASPARTIC ACID, DECYL-BETA-D-MALTOPYRANOSIDE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Arkhipova, V, Guskov, A, Slotboom, D.J. | Deposit date: | 2019-03-29 | Release date: | 2019-04-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Binding and transport of D-aspartate by the glutamate transporter homolog Glt Tk . Elife, 8, 2019
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5E9S
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6ZLH
| the structure of glutamate transporter homologue GltTk in complex with the photo switchable compound (trans) | Descriptor: | (2~{S},3~{S})-2-azanyl-3-[[4-[2-(4-methoxyphenyl)hydrazinyl]phenyl]methoxy]butanedioic acid, DECYL-BETA-D-MALTOPYRANOSIDE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Arkhipova, V, Slotboom, D.J, Guskov, A. | Deposit date: | 2020-06-30 | Release date: | 2021-01-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue. J.Am.Chem.Soc., 143, 2021
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8CTC
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7UGJ
| TBOA-bound GltPh RSMR mutant in OFS state | Descriptor: | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | Authors: | Huang, Y, Boudker, O. | Deposit date: | 2022-03-24 | Release date: | 2023-03-29 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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6X2L
| hEAAT3-IFS-Na | Descriptor: | Excitatory amino acid transporter 3 | Authors: | Qiu, B, Matthies, D, Boudker, O. | Deposit date: | 2020-05-20 | Release date: | 2021-03-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
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8CUD
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7UGV
| Asp-bound GltPh RSMR mutant in IFS-A2 state | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | Authors: | Huang, Y, Boudker, O. | Deposit date: | 2022-03-25 | Release date: | 2023-03-29 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19 F NMR and Cryo-EM. J.Am.Chem.Soc., 145, 2023
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7UGD
| Asp-bound GltPh RSMR mutant in IFS-A1 state | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | Authors: | Huang, Y, Boudker, O. | Deposit date: | 2022-03-24 | Release date: | 2023-03-29 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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2NWL
| Crystal structure of GltPh in complex with L-Asp | Descriptor: | ASPARTIC ACID, PALMITIC ACID, glutamate symport protein | Authors: | Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K. | Deposit date: | 2006-11-15 | Release date: | 2007-02-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature, 445, 2007
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7UGX
| Asp-bound GltPh RSMR mutant in IFS-B1 state | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | Authors: | Huang, Y, Boudker, O. | Deposit date: | 2022-03-25 | Release date: | 2023-03-29 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19 F NMR and Cryo-EM. J.Am.Chem.Soc., 145, 2023
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7UH3
| Asp-bound GltPh RSMR mutant in iOFS state | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | Authors: | Huang, Y, Boudker, O. | Deposit date: | 2022-03-25 | Release date: | 2023-03-29 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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6ZL4
| the structure of glutamate transporter homologue GltTk in complex with the photo switchable compound (cis) | Descriptor: | (2~{S},3~{S})-2-azanyl-3-[[4-[2-(4-methoxyphenyl)hydrazinyl]phenyl]methoxy]butanedioic acid, DECYL-BETA-D-MALTOPYRANOSIDE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Arkhipova, V, Slotboom, D.J, Guskov, A. | Deposit date: | 2020-06-30 | Release date: | 2021-01-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue. J.Am.Chem.Soc., 143, 2021
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4KY0
| Crystal structure of a substrate-free glutamate transporter homologue from Thermococcus kodakarensis | Descriptor: | Proton/glutamate symporter, SDF family, TETRAETHYLENE GLYCOL | Authors: | Guskov, A, Jensen, S, Rempel, S, Hanelt, I, Slotboom, D.J. | Deposit date: | 2013-05-28 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a substrate-free aspartate transporter. Nat.Struct.Mol.Biol., 20, 2013
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6X2Z
| hEAAT3-OFS-Asp | Descriptor: | ASPARTIC ACID, Excitatory amino acid transporter 3, SODIUM ION | Authors: | Qiu, B, Matthies, D, Boudker, O. | Deposit date: | 2020-05-21 | Release date: | 2021-03-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
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6X3F
| hEAAT3-IFS-Apo | Descriptor: | CHOLINE ION, Excitatory amino acid transporter 3 | Authors: | Qiu, B, Matthies, D, Boudker, O. | Deposit date: | 2020-05-21 | Release date: | 2021-03-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
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8CUJ
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