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3QTE	Crystal structure of human alpha-defensin 6 (H27W mutant) Descriptor: CHLORIDE ION, Defensin-6, GLYCEROL Authors: Pazgier, M, Lu, W. Deposit date: 2011-02-22 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.949 Å) Cite: Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science, 337, 2012
7YOA	High-resolution crystal structure of the mouse alpha-defensin cryptdin 14 Descriptor: Alpha-defensin 14, SULFATE ION Authors: Yang, Y, Lu, W. Deposit date: 2022-08-01 Release date: 2022-11-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Mouse alpha-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt. Infect.Immun., 91, 2023
6KRA	Solution NMR Structure of RMAD4 alpha Defensin Descriptor: Neutrophil defensin 4 Authors: Agadi, N, Kumar, A, Shukla, V.K. Deposit date: 2019-08-21 Release date: 2020-08-26 Method: SOLUTION NMR Cite: Solution NMR Structure of RMAD4 alpha Defensin. To Be Published
1DFN	CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION Descriptor: DEFENSIN HNP-3 Authors: Hill, C.P, Yee, J, Selsted, M.E, Eisenberg, D. Deposit date: 1991-01-18 Release date: 1992-07-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science, 251, 1991
4DU0	Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant) Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 Authors: Wu, X, Lu, W, Pazgier, M. Deposit date: 2012-02-21 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1 J.Biol.Chem., 287, 2012
2K1I	Synthesis, Structure and Activities of an Oral Mucosal Alpha-Defensin from Rhesus Macaque Descriptor: Mucosal Alpha-Defensin Authors: Vasudevan, S.V, Yuan, J, Osapay, G, Tran, P, Tai, K, Selsted, M, Cocco, M.J. Deposit date: 2008-03-05 Release date: 2008-10-28 Last modified: 2018-01-24 Method: SOLUTION NMR Cite: Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J.Biol.Chem., 283, 2008
6DMQ	Crystal structure of the T27A mutant of human alpha defensin HNP4. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4 Authors: Gohain, N, Tolbert, W.D, Pazgier, M. Deposit date: 2018-06-05 Release date: 2019-01-30 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Systematic mutational analysis of human neutrophil alpha-defensin HNP4. Biochim Biophys Acta Biomembr, 1861, 2019
6DMM	Crystal structure of the G23A mutant of human alpha defensin HNP4. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4, SULFATE ION Authors: Gohain, N, Tolbert, W.D, Pazgier, M. Deposit date: 2018-06-05 Release date: 2019-01-30 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Systematic mutational analysis of human neutrophil alpha-defensin HNP4. Biochim Biophys Acta Biomembr, 1861, 2019
4RBW	Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant) Descriptor: CHLORIDE ION, Defensin-5, SULFATE ION Authors: Pazgier, M, Gohain, N, Tolbert, W.D. Deposit date: 2014-09-13 Release date: 2015-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58, 2015
4RBX	Crystal structure of human alpha-defensin 5, HD5 (Glu21Arg mutant) Descriptor: Defensin-5, SULFATE ION Authors: Pazgier, M, Gohain, N, Tolbert, W.D. Deposit date: 2014-09-13 Release date: 2015-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58, 2015
4E86	Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant) Descriptor: CHLORIDE ION, Defensin-5 Authors: Wu, X, Pazgier, M. Deposit date: 2012-03-19 Release date: 2012-05-16 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface. J.Biol.Chem., 287, 2012
4E82	Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant) Descriptor: Defensin-5 Authors: Pazgier, M. Deposit date: 2012-03-19 Release date: 2012-05-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface. J.Biol.Chem., 287, 2012
4E83	Crystal structure of human alpha-defensin 5, HD5 (Leu29NLe mutant) Descriptor: CHLORIDE ION, Defensin-5 Authors: Pazgier, M. Deposit date: 2012-03-19 Release date: 2012-05-16 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface. J.Biol.Chem., 287, 2012
5CUJ	Crystal structure of Human Defensin-5 Y27A mutant crystal form 2. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... Authors: Tolbert, W.D, Gohain, N, Pazgier, M. Deposit date: 2015-07-24 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
5CUI	Crystal structure of Human Defensin-5 R28A mutant. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, ... Authors: Tolbert, W.D, Gohain, N, Pazgier, M. Deposit date: 2015-07-24 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.403 Å) Cite: Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
5CUM	Crystal structure of Human Defensin-5 Y27A mutant crystal form 1. Descriptor: CALCIUM ION, CHLORIDE ION, Defensin-5, ... Authors: Tolbert, W.D, Gohain, N, Pazgier, M. Deposit date: 2015-07-24 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.752 Å) Cite: Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
4LBF	Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant Descriptor: GLYCEROL, Neutrophil defensin 1 Authors: Tolbert, W.D, Wu, X, Pazgier, M. Deposit date: 2013-06-20 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8, 2013
4LB1	Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant Descriptor: Neutrophil defensin 1 Authors: Tolbert, W.D, Wu, X, Pazgier, M. Deposit date: 2013-06-20 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8, 2013
4LBB	Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant Descriptor: CHLORIDE ION, Neutrophil defensin 1 Authors: Tolbert, W.D, Wu, X, Pazgier, M. Deposit date: 2013-06-20 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.719 Å) Cite: Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8, 2013
4LB7	Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant. Descriptor: Neutrophil defensin 1 Authors: Tolbert, W.D, Wu, X, Pazgier, M. Deposit date: 2013-06-20 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.902 Å) Cite: Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8, 2013
3GNY	Crystal structure of human alpha-defensin 1 (HNP1) Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W.-Y. Deposit date: 2009-03-18 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Through the looking glass, mechanistic insights from enantiomeric human defensins. J.Biol.Chem., 284, 2009
3H6C	Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala) Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W. Deposit date: 2009-04-23 Release date: 2010-03-09 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3HJ2	Crystal structure of covalent dimer of HNP1 Descriptor: HUMAN NEUTROPHIL PEPTIDE 1 Authors: Lubkowski, J, Pazgier, M, Lu, W. Deposit date: 2009-05-20 Release date: 2009-10-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: What Dictates the Multifaced Functions of the Human alpha-Defensin HNP1? To be Published
3HJD	X-ray structure of monomeric variant of HNP1 Descriptor: Human neutrophil peptide 1 Authors: Lubkowski, J, Pazgier, M, Lu, W. Deposit date: 2009-05-21 Release date: 2009-10-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: What Dictates the Multifaced Functions of the Human alpha-Defensin HNP? To be Published
3I5W	Crystal structure of human alpha-defensin 5 (mutant R13H) Descriptor: CHLORIDE ION, CITRATE ANION, Defensin-5 Authors: Pazgier, M, Lu, W. Deposit date: 2009-07-06 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5 Febs Lett., 583, 2009

 

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