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4US4
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BU of 4us4 by Molmil
Crystal Structure of the Bacterial NSS Member MhsT in an Occluded Inward-Facing State (lipidic cubic phase form)
Descriptor: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, SODIUM ION, ...
Authors:Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P.
Deposit date:2014-07-02
Release date:2014-09-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters
Nat.Struct.Mol.Biol., 21, 2014
2A65
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BU of 2a65 by Molmil
Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E.
Deposit date:2005-07-01
Release date:2005-08-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
7SK2
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BU of 7sk2 by Molmil
Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation
Descriptor: Sodium- and chloride-dependent GABA transporter 1, Tiagabine
Authors:Gati, C, Motiwala, Z, Aduri, N.G, Shaye, H, Han, G.W, Cherezov, V.
Deposit date:2021-10-19
Release date:2022-06-08
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structural basis of GABA reuptake inhibition.
Nature, 606, 2022
4US3
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BU of 4us3 by Molmil
Crystal Structure of the bacterial NSS member MhsT in an Occluded Inward-Facing State
Descriptor: DODECYL-ALPHA-D-MALTOSIDE, SODIUM ION, TRANSPORTER, ...
Authors:Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P.
Deposit date:2014-07-02
Release date:2014-09-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters
Nat.Struct.Mol.Biol., 21, 2014
8FT5
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BU of 8ft5 by Molmil
Crystal structure of LeuT soaked with Crown-5
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
Deposit date:2023-01-11
Release date:2023-11-22
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
8FT4
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Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
Deposit date:2023-01-11
Release date:2023-11-22
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
8DE3
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BU of 8de3 by Molmil
Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
Descriptor: 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2022-06-19
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
To Be Published
8DE4
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BU of 8de4 by Molmil
Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
Descriptor: (2S)-N-methyl-1-phenylpropan-2-amine, 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2022-06-19
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
To be published
6W2B
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BU of 6w2b by Molmil
Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, ...
Authors:Coleman, J.A, Navratna, V, Yang, D.
Deposit date:2020-03-05
Release date:2020-03-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.7 Å)
Cite:Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
6YU2
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BU of 6yu2 by Molmil
Crystal structure of MhsT in complex with L-isoleucine
Descriptor: ISOLEUCINE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6ZBV
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BU of 6zbv by Molmil
Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7
Descriptor: Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone
Authors:Shahsavar, A, Stohler, P, Bourenkov, G, Zimmermann, I, Siegrist, M, Guba, W, Pinard, E, Sinning, S, Seeger, M.A, Schneider, T.R, Dawson, R.J.P, Nissen, P.
Deposit date:2020-06-09
Release date:2021-03-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural insights into the inhibition of glycine reuptake.
Nature, 591, 2021
8GNK
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BU of 8gnk by Molmil
CryoEM structure of cytosol-facing, substrate-bound ratGAT1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ...
Authors:Nayak, S.R, Joseph, D, Penmatsa, A.
Deposit date:2022-08-24
Release date:2023-05-31
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.
Nat.Struct.Mol.Biol., 30, 2023
4FXZ
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BU of 4fxz by Molmil
Crystal structure of LeuT-F253A bound to L-leucine from lipid bicelles
Descriptor: ACETATE ION, LEUCINE, SODIUM ION, ...
Authors:Wang, H, Gouaux, E.
Deposit date:2012-07-03
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.
Embo Rep., 13, 2012
4FY0
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BU of 4fy0 by Molmil
Crystal structure of LeuT-F253A bound to L-selenomethionine from lipid bicelles
Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter
Authors:Wang, H, Gouaux, E.
Deposit date:2012-07-03
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.
Embo Rep., 13, 2012
6DZY
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BU of 6dzy by Molmil
Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine
Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
Authors:Coleman, J.A, Yang, D, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZV
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BU of 6dzv by Molmil
Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded conformation
Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
Authors:Coleman, J.A, Yang, D, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZZ
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BU of 6dzz by Molmil
Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation
Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
Authors:Yang, D, Coleman, J.A, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZW
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BU of 6dzw by Molmil
Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and 15B8 Fab and 8B6 ScFv
Descriptor: 15B8 antibody heavy chain, 15B8 antibody light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Coleman, J.A, Yang, D, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
4HMK
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BU of 4hmk by Molmil
Crystal structure of LeuT-E290S with bound Br
Descriptor: BROMIDE ION, LEUCINE, SODIUM ION, ...
Authors:Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P.
Deposit date:2012-10-18
Release date:2013-05-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:The chloride binding site of Neurotransmitter Sodium Symporters
Proc.Natl.Acad.Sci.USA, 2013
4HOD
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BU of 4hod by Molmil
Crystal structure of LeuT-E290S with bound Cl
Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ...
Authors:Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P.
Deposit date:2012-10-22
Release date:2013-05-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The chloride binding site of Neurotransmitter Sodium Symporters
Proc.Natl.Acad.Sci.USA, 2013
3GJD
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BU of 3gjd by Molmil
Crystal Structure of LeuT with bound OG
Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GJC
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BU of 3gjc by Molmil
Crystal Structure of the E290S mutant of LeuT with bound OG
Descriptor: LEUCINE, SODIUM ION, Transporter, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GWV
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BU of 3gwv by Molmil
Leucine transporter LeuT in complex with R-fluoxetine
Descriptor: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWU
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BU of 3gwu by Molmil
Leucine transporter LeuT in complex with sertraline
Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3MPQ
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BU of 3mpq by Molmil
I204R1 mutant of LeuT
Descriptor: CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ...
Authors:Kroncke, B.M.
Deposit date:2010-04-27
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010

217705

數據於2024-03-27公開中

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