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4XO0
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BU of 4xo0 by Molmil
Crystal structure of 5'-CTTATPPTAZZATAAG in a host-guest complex
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*T)-3'), DNA (5'-D(P*AP*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3'), reverse transcriptase
Authors:Georgiadis, M.M, Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XPC
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BU of 4xpc by Molmil
Crystal structure of 5'- CTTATAAATTTATAAG in a host-guest complex
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*TP*TP*AP*TP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*TP*AP*AP*G)-3'), ...
Authors:Georgiadis, M.M, Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XPE
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BU of 4xpe by Molmil
Crystal structure of 5'-CTTATGGGCCCATAAG in a host-guest complex
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*TP*TP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*AP*AP*G)-3'), ...
Authors:Georgiadis, M.M, Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
8IBW
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BU of 8ibw by Molmil
Structure of R2 with 3'UTR and DNA in binding state
Descriptor: 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ...
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
8IBX
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BU of 8ibx by Molmil
Structure of R2 with 3'UTR and DNA in unwinding state
Descriptor: 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ...
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
8IBZ
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BU of 8ibz by Molmil
Structure of R2 with 5'ORF and 3'UTR
Descriptor: 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
8IBY
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BU of 8iby by Molmil
Structure of R2 with 5'ORF
Descriptor: 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
1ZTT
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BU of 1ztt by Molmil
Netropsin bound to d(CTTAATTCGAATTAAG) in complex with MMLV RT catalytic fragment
Descriptor: 5'-D(*CP*TP*TP*AP*AP*TP*TP*C)-3', 5'-D(P*GP*AP*AP*TP*TP*AP*AP*G)-3', NETROPSIN, ...
Authors:Goodwin, K.D, Long, E.C, Georgiadis, M.M.
Deposit date:2005-05-27
Release date:2005-08-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A host-guest approach for determining drug-DNA interactions: an example using netropsin.
Nucleic Acids Res., 33, 2005
1ZTW
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BU of 1ztw by Molmil
d(CTTAATTCGAATTAAG) complexed with Moloney Murine Leukemia Virus Reverse Transcriptase catalytic fragment
Descriptor: CTTAATTC, GAATTAAG, Reverse transcriptase
Authors:Goodwin, K.D, Long, E.C, Georgiadis, M.M.
Deposit date:2005-05-27
Release date:2005-08-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A host-guest approach for determining drug-DNA interactions: an example using netropsin.
Nucleic Acids Res., 33, 2005
8BGJ
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BU of 8bgj by Molmil
Crystal structure of Reverse Transcriptase domain from Caloramator australicus CART-CAPP
Descriptor: L(+)-TARTARIC ACID, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ...
Authors:Li, A.W.H, Doherty, A.J.
Deposit date:2022-10-27
Release date:2023-06-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Reverse transcriptases prime DNA synthesis.
Nucleic Acids Res., 51, 2023
8C8J
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BU of 8c8j by Molmil
Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, ...
Authors:Nichols, C.E, Walpole, T.B, Baldwin, E.
Deposit date:2023-01-20
Release date:2023-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
8CS0
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BU of 8cs0 by Molmil
Crystal structure of alien DNA CTSZZPBSBSZPPBAG in a host-guest complex with the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase
Descriptor: DNA (5'-D(*CP*TP*(JSP)P*(1W5)P*(1W5)P*(1WA)P*(IGU)P*(JSP))-3'), DNA (5'-D(P*(IGU)P*(JSP)P*(1W5)P*(1WA)P*(1WA)P*(IGU)P*AP*G)-3'), reverse transcriptase
Authors:Georgiadis, M.M.
Deposit date:2022-05-12
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Alien DNA visualized at high resolution in A- and B-forms
To Be Published
8DWM
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BU of 8dwm by Molmil
Host-guest complex of bleomycin A2 fully bound to CTTAGTTATAACTAAG
Descriptor: BLEOMYCIN A2, COBALT (III) ION, DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), ...
Authors:Georgiadis, M.M.
Deposit date:2022-08-01
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites.
Bioorg.Med.Chem., 77, 2023
8DW8
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BU of 8dw8 by Molmil
Host-guest structure of BLMA2 partially bound to 5'-ATTAGTTATAACTAAT-3'
Descriptor: BLEOMYCIN A2, DNA (5'-D(*AP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*T)-3'), ...
Authors:Georgiadis, M.M.
Deposit date:2022-07-31
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites.
Bioorg.Med.Chem., 77, 2023
8DW1
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BU of 8dw1 by Molmil
Crystal structure of a host-guest complex with 5'-CTTAGTTATAACTAAG-3'
Descriptor: DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*G)-3'), reverse transcriptase
Authors:Georgiadis, M.M.
Deposit date:2022-07-30
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites.
Bioorg.Med.Chem., 77, 2023
1D0E
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BU of 1d0e by Molmil
CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN
Descriptor: 5'-D(*TP*TP*TP*CP*AP*TP*GP*CP*AP*TP*G)-3', REVERSE TRANSCRIPTASE
Authors:Najmudin, S, Cote, M.L, Sun, D, Yohannan, S, Montano, S.P, Gu, J, Georgiadis, M.M.
Deposit date:1999-09-09
Release date:2000-04-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain
J.Mol.Biol., 296, 2000
1D1U
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BU of 1d1u by Molmil
USE OF AN N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE TO FACILITATE CRYSTALLIZATION AND ANALYSIS OF A PSEUDO-16-MER DNA MOLECULE CONTAINING G-A MISPAIRS
Descriptor: DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3'), DNA (5'-D(*CP*TP*CP*GP*TP*G)-3'), PROTEIN (REVERSE TRANSCRIPTASE)
Authors:Cote, M.L, Yohannan, S, Georgiadis, M.M.
Deposit date:1999-09-21
Release date:2000-04-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Use of an N-terminal fragment from moloney murine leukemia virus reverse transcriptase to facilitate crystallization and analysis of a pseudo-16-mer DNA molecule containing G-A mispairs.
Acta Crystallogr.,Sect.D, 56, 2000
2R2U
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BU of 2r2u by Molmil
Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment
Descriptor: DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DT)-3'), DNA (5'-D(P*DTP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), N-(4-{[amino(imino)methyl]amino}butyl)-2,4'-bi-1,3-thiazole-4-carboxamide, ...
Authors:Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M.
Deposit date:2007-08-27
Release date:2008-07-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2R2R
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BU of 2r2r by Molmil
d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment
Descriptor: DNA (5'-D(*DAP*DTP*DTP*DAP*DGP*DTP*DTP*DA)-3'), DNA (5'-D(P*DTP*DAP*DAP*DCP*DTP*DAP*DAP*DT)-3'), Reverse transcriptase
Authors:Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M.
Deposit date:2007-08-27
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2R2S
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BU of 2r2s by Molmil
Co(III)bleomycinB2 bound to d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment
Descriptor: BLEOMYCIN B2, COBALT (III) ION, DNA (5'-D(*DAP*DTP*DTP*DAP*DGP*DTP*DT)-3'), ...
Authors:Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M.
Deposit date:2007-08-27
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2R2T
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BU of 2r2t by Molmil
d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment
Descriptor: DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DTP*DT)-3'), DNA (5'-D(P*DAP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), Reverse transcriptase
Authors:Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M.
Deposit date:2007-08-27
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Proc.Natl.Acad.Sci.Usa, 105, 2008
6MIH
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BU of 6mih by Molmil
Crystal structure of host-guest complex with PC hachimoji DNA
Descriptor: DNA (5'-D(*CP*TP*TP*AP*(1WA)P*CP*(DB)P*T)-3'), DNA (5'-D(P*AP*(DS)P*GP*(1W5)P*TP*AP*AP*G)-3'), N-terminal fragment of MMLV reverse transcriptase
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIG
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BU of 6mig by Molmil
Crystal structure of host-guest complex with PB hachimoji DNA
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3'), Gag-Pol polyprotein
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIK
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BU of 6mik by Molmil
Crystal structure of host-guest complex with PP hachimoji DNA
Descriptor: DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3'), N-terminal fragment of MMLV reverse transcriptase
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
2FJV
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BU of 2fjv by Molmil
RT29 Bound to D(CTTAATTCGAATTAAG) in complex with MMLV RT Catalytic Fragment
Descriptor: 2-(4-(4-CARBAMIMIDOYLPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXIMIDAMIDE, 5'-D(*CP*TP*TP*AP*AP*TP*TP*C)-3', 5'-D(P*GP*AP*AP*TP*TP*AP*AP*G)-3', ...
Authors:Goodwin, K.D, Georgiadis, M.M.
Deposit date:2006-01-03
Release date:2006-06-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents: Analysis of a "Highly Twisted" Benzimidazole-Diamidine.
J.Am.Chem.Soc., 128, 2006

217705

數據於2024-03-27公開中

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