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7ZGO
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BU of 7zgo by Molmil
Cryo-EM structure of human NKCC1 (TM domain)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Nissen, P, Fenton, R, Neumann, C, Lindtoft Rosenbaek, L, Kock Flygaard, R, Habeck, M, Lykkegaard Karlsen, J, Wang, Y, Lindorff-Larsen, K, Gad, H, Hartmann, R, Lyons, J.
Deposit date:2022-04-04
Release date:2022-10-05
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.
Embo J., 41, 2022
7D10
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BU of 7d10 by Molmil
Human NKCC1
Descriptor: PALMITIC ACID, Solute carrier family 12 member 2
Authors:Zhang, S, Yang, M.
Deposit date:2020-09-12
Release date:2021-04-14
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2.
Commun Biol, 4, 2021
6PZT
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BU of 6pzt by Molmil
cryo-EM structure of human NKCC1
Descriptor: Solute carrier family 12 member 2
Authors:Cao, E, Wang, Q, Yang, X.
Deposit date:2019-08-01
Release date:2020-03-25
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.
Nat Commun, 11, 2020
7N3N
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BU of 7n3n by Molmil
CryoEM structure of human NKCC1 state Fu-I
Descriptor: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-06-01
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
7S1Z
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BU of 7s1z by Molmil
Cryo-EM structure of Human NKCC1 K289NA492EL671C
Descriptor: Solute carrier family 12 member 2
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1X
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BU of 7s1x by Molmil
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Y
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BU of 7s1y by Molmil
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.h.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7YG1
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BU of 7yg1 by Molmil
Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter
Descriptor: Solute carrier family 12 member 3
Authors:Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q.
Deposit date:2022-07-09
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
7YG0
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BU of 7yg0 by Molmil
Cryo-EM structure of human sodium-chloride cotransporter
Descriptor: Solute carrier family 12 member 3
Authors:Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q.
Deposit date:2022-07-09
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
7Y6I
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BU of 7y6i by Molmil
Cryo-EM structure of human sodium-chloride cotransporter
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nan, J, Yang, X, Shan, Z, Yuan, Y, Zhang, Y.Q.
Deposit date:2022-06-20
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
8FHT
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BU of 8fht by Molmil
Cryo-EM structure of human NCC
Descriptor: CHLORIDE ION, SODIUM ION, Solute carrier family 12 member 3
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-15
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHR
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BU of 8fhr by Molmil
Cryo-EM structure of human NCC (class 3-3)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHQ
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BU of 8fhq by Molmil
Cryo-EM structure of human NCC (class 3-2)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHP
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BU of 8fhp by Molmil
Cryo-EM structure of human NCC (class 3-1)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHO
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BU of 8fho by Molmil
Cryo-EM structure of human NCC (class 1)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, SODIUM ION, ...
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHN
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BU of 8fhn by Molmil
Cryo-EM structure of human NCC (class 2)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023

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数据于2024-03-27公开中

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