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8FII
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BU of 8fii by Molmil
Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 1)
Descriptor: DNA (5'-D(P*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*C)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ...
Authors:Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M.
Deposit date:2022-12-16
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
8FIK
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BU of 8fik by Molmil
APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate
Descriptor: CHLORIDE ION, DNA (5'-D(P*CP*CP*CP*AP*TP*CP*AP*TP*TP*CP*GP*AP*TP*GP*GP*G)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ...
Authors:Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M.
Deposit date:2022-12-16
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
8FIJ
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BU of 8fij by Molmil
Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 2)
Descriptor: DNA (5'-D(*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ...
Authors:Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M.
Deposit date:2022-12-16
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
8FIL
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BU of 8fil by Molmil
Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate
Descriptor: CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ...
Authors:Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M.
Deposit date:2022-12-16
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
8FIM
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BU of 8fim by Molmil
Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate
Descriptor: CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ...
Authors:Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M.
Deposit date:2022-12-16
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
8H0I
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BU of 8h0i by Molmil
Cryo-EM structure of APOBEC3G-Vif complex
Descriptor: APOBEC3G, CHLORIDE ION, Core binding factor beta, ...
Authors:Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M.
Deposit date:2022-09-29
Release date:2023-07-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Nat Commun, 14, 2023
8J62
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BU of 8j62 by Molmil
Cryo-EM structure of APOBEC3G-Vif complex
Descriptor: APOBEC3G, Core binding factor beta, RNA (5'-R(*CP*GP*GP*UP*UP*GP*AP*UP*UP*GP*UP*UP*UP*UP*AP*AP*CP*AP*A)-3'), ...
Authors:Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M.
Deposit date:2023-04-24
Release date:2023-07-19
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Nat Commun, 14, 2023
8CX1
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BU of 8cx1 by Molmil
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1
Descriptor: Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ...
Authors:Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D.
Deposit date:2022-05-19
Release date:2023-02-15
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
8CX0
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BU of 8cx0 by Molmil
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex
Descriptor: Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ...
Authors:Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D.
Deposit date:2022-05-19
Release date:2023-02-15
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
8CX2
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BU of 8cx2 by Molmil
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2
Descriptor: Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ...
Authors:Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D.
Deposit date:2022-05-19
Release date:2023-02-15
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
7UXD
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BU of 7uxd by Molmil
Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy Zebularine.
Descriptor: DNA (5'-D(*AP*AP*TP*CP*CP*(DDN)P*AP*AP*A)-3'), DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Maiti, A, Matsuo, H.
Deposit date:2022-05-05
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.
Nat Commun, 13, 2022
7RW6
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BU of 7rw6 by Molmil
BORF2-APOBEC3Bctd Complex
Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION
Authors:Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S.
Deposit date:2021-08-19
Release date:2022-04-27
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
7D3V
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BU of 7d3v by Molmil
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Cao, C.Y, Liu, Y.P, Lan, W.X.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3
To Be Published
7D3W
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BU of 7d3w by Molmil
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Cao, C, Liu, Y, Lan, W.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Two different kinds of interaction modes of deaminase APOBEC3A with single-stranded DNA in solution detected by nuclear magnetic resonance.
Protein Sci., 31, 2022
7D3X
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BU of 7d3x by Molmil
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Cao, C, Liu, Y.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Two different kinds of interaction modes of deaminase APOBEC3A with single-stranded DNA in solution detected by nuclear magnetic resonance.
Protein Sci., 31, 2022
6X91
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BU of 6x91 by Molmil
Crystal structure of MBP-fused human APOBEC1
Descriptor: CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ...
Authors:Wolfe, A.D, Li, S.-X, Chen, X.S.
Deposit date:2020-06-02
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
NAR Cancer, 2, 2020
6NFK
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BU of 6nfk by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G bound to iodide
Descriptor: 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IODIDE ION
Authors:Shi, K, Orellana, K, Aihara, H.
Deposit date:2018-12-20
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B
Faseb Bioadv, 2, 2020
6NFM
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BU of 6nfm by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G
Descriptor: CHLORIDE ION, DNA dC->dU-editing enzyme APOBEC-3B
Authors:Shi, K, Aihara, H.
Deposit date:2018-12-20
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B
Faseb Bioadv, 2, 2020
6NFL
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BU of 6nfl by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G complexed with 2-HP
Descriptor: 1,2-ETHANEDIOL, 1,3-diazinan-2-one, CHLORIDE ION, ...
Authors:Shi, K, Orellana, K, Aihara, H.
Deposit date:2018-12-20
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.731 Å)
Cite:Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B
Faseb Bioadv, 2, 2020
6K3K
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BU of 6k3k by Molmil
Solution structure of APOBEC3G-CD2 with ssDNA, Product B
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, DNA/RNA (5'-D(*AP*TP*TP*CP*UP*(ICY)P*AP*AP*TP*T)-3'), ZINC ION
Authors:Cao, C, Yan, X, Lan, W, Wang, C.
Deposit date:2019-05-19
Release date:2019-06-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA.
Chem Asian J, 14, 2019
6K3J
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BU of 6k3j by Molmil
Solution structure of APOBEC3G-CD2 with ssDNA, Product A
Descriptor: DNA (5'-D(*AP*TP*TP*CP*UP*(IUR)P*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Cao, C, Yan, X, Lan, W, Wang, C.
Deposit date:2019-05-19
Release date:2019-06-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA.
Chem Asian J, 14, 2019
6BUX
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BU of 6bux by Molmil
CRYSTAL STRUCTURE OF APOBEC3G CATALYTIC DOMAIN COMPLEX WITH SUBSTRATE SSDNA
Descriptor: Apolipoprotein B mRNA editing enzyme catalytic subunit 3G catalytic domain, DNA (5'-D(*AP*AP*TP*CP*CP*CP*AP*AP*A)-3'), GLYCEROL, ...
Authors:Maiti, A, Matsuo, H.
Deposit date:2017-12-11
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.856 Å)
Cite:Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
Nat Commun, 9, 2018
6BWY
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BU of 6bwy by Molmil
DNA substrate selection by APOBEC3G
Descriptor: DNA (30-MER), PHOSPHATE ION, Protection of telomeres protein 1, ...
Authors:Ziegler, S.J, Buzovetsky, O.
Deposit date:2017-12-15
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
PLoS ONE, 13, 2018
5SXG
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BU of 5sxg by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Descriptor: 1,3-PROPANDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IMIDAZOLE, ...
Authors:Shi, K, Kurahashi, K, Aihara, H.
Deposit date:2016-08-09
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Sci Rep, 7, 2017
5SXH
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BU of 5sxh by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Descriptor: 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION
Authors:Shi, K, Kurahashi, K, Aihara, H.
Deposit date:2016-08-09
Release date:2017-12-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Sci Rep, 7, 2017

 

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数据于2024-03-27公开中

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