PDB: 145 resultsInfo pagesStatus searchChemie searchBIRD

---

8HBS	Crystal of rAlfNmt Descriptor: Glycylpeptide N-tetradecanoyltransferase Authors: Wang, Y, Wang, S. Deposit date: 2022-10-30 Release date: 2023-03-08 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.78 Å) Cite: N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus. Microbiol Spectr, 11, 2023
7RK3	Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A Descriptor: 4'-diphospho pantetheine, ADP-ribosylation factor 6, Glycylpeptide N-tetradecanoyltransferase 1, ... Authors: Fenwick, M.K, Lin, H. Deposit date: 2021-07-21 Release date: 2022-07-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A To Be Published
4UWJ	Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a capped pyrazole sulphonamide ligand Descriptor: 2,6-dichloro-N-(difluoromethyl)-4-[3-(piperidin-4-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA Authors: Robinson, D.A, Brand, S, Norcross, N.R, Thompson, S, Harrison, J.R, Smith, V.C, Torrie, L.S, McElroy, S.P, Hallyburton, I, Norval, S, Stojanovski, L, Simeons, F.R.C, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Wyatt, P.G, Gilbert, I.H, Read, K.D. Deposit date: 2014-08-12 Release date: 2014-12-03 Last modified: 2018-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis. J. Med. Chem., 57, 2014
6B1L	Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001173 Descriptor: 1-(5-fluoro-2-{methyl[3-(methylamino)propyl]amino}pyrimidin-4-yl)-N-[(imidazo[1,2-a]pyridin-3-yl)methyl]azetidine-3-carboxamide, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-09-18 Release date: 2018-09-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001173 to be published
4QBJ	Crystal structure of N-myristoyl transferase from Aspergillus fumigatus complexed with a synthetic inhibitor Descriptor: 3-[[3-methyl-2-[[2,3,4-tris(fluoranyl)phenoxy]methyl]-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)propan-1-amine, Glycylpeptide N-tetradecanoyltransferase, S-(2-OXO)PENTADECYLCOA, ... Authors: Suzuki, M, Shimada, T. Deposit date: 2014-05-08 Release date: 2015-04-01 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of N-myristoyltransferase from Aspergillus fumigatus Acta Crystallogr.,Sect.D, 71, 2015
4A95	Plasmodium vivax N-myristoyltransferase with quinoline inhibitor Descriptor: 2-oxopentadecyl-CoA, 3-(3-BUTYL-6-METHOXY-2-METHYL-QUINOLIN-4-YL)SULFANYLPROPANENITRILE, CHLORIDE ION, ... Authors: Goncalves, V, Brannigan, J.A, Whalley, D, Ansell, K.H, Saxty, B, Holder, A.A, Wilkinson, A.J, Tate, E.W, Leatherbarrow, R.J. Deposit date: 2011-11-24 Release date: 2012-06-27 Last modified: 2012-07-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Discovery of Plasmodium Vivax N-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of Their Binding Mode. J.Med.Chem., 55, 2012
1NMT	N-MYRISTOYL TRANSFERASE FROM CANDIDA ALBICANS AT 2.45 A Descriptor: GLYCEROL, N-MYRISTOYL TRANSFERASE Authors: Weston, S.A, Pauptit, R.A. Deposit date: 1997-12-11 Release date: 1999-01-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal structure of the anti-fungal target N-myristoyl transferase. Nat.Struct.Biol., 5, 1998
1RXT	Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase. Descriptor: COBALT (II) ION, Glycylpeptide N-tetradecanoyltransferase 1, SULFATE ION Authors: Yang, J, Wang, Y, Frey, G, Abeles, R.H, Petsko, G.A, Ringe, D. Deposit date: 2003-12-18 Release date: 2005-04-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase To be Published
5UUT	N-myristoyltransferase 1 (NMT) bound to myristoyl-CoA Descriptor: CITRIC ACID, Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA Authors: Goodwin, O, Pegan, S. Deposit date: 2017-02-17 Release date: 2018-01-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.252 Å) Cite: Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression. Cancer Res., 77, 2017
5V0X	Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001114 Descriptor: CHLORIDE ION, Glycylpeptide N-tetradecanoyltransferase, SULFATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-02-28 Release date: 2018-03-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001114 to be published
5V0W	Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001088 Descriptor: 1-[5-[3,4-bis(fluoranyl)-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-1-methyl-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, CHLORIDE ION, Glycylpeptide N-tetradecanoyltransferase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-02-28 Release date: 2018-03-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001088 to be published
2NMT	MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE BOUND TO MYRISTOYL-COA AND PEPTIDE ANALOGS Descriptor: GLYCEROL, MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE, S-(2-OXO)PENTADECYLCOA, ... Authors: Fuetterer, K, Bhatnagar, R.S, Waksman, G. Deposit date: 1998-07-14 Release date: 1999-01-06 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs. Nat.Struct.Biol., 5, 1998
1IIC	Crystal Structure of Saccharomyces cerevisiae N-myristoyltransferase with Bound MyristoylCoA Descriptor: PEPTIDE N-myristoyltransferase, TETRADECANOYL-COA Authors: Farazi, T.A, Waksman, G, Gordon, J.I. Deposit date: 2001-04-22 Release date: 2001-05-02 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Biochemistry, 40, 2001
1IYK	Crystal structure of candida albicans N-myristoyltransferase with myristoyl-COA and peptidic inhibitor Descriptor: MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE, TETRADECANOYL-COA, [CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE Authors: Sogabe, S, Fukami, T.A, Morikami, K, Shiratori, Y, Aoki, Y, D'Arcy, A, Winkler, F.K, Banner, D.W, Ohtsuka, T. Deposit date: 2002-08-29 Release date: 2002-12-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors CHEM.BIOL., 9, 2002
1IYL	Crystal Structure of Candida albicans N-myristoyltransferase with Non-peptidic Inhibitor Descriptor: (1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRIDIN-3-YLMETHYL)-AMINO]-PROPOXY}-BENZOFURAN-2-YL)-METHANONE, Myristoyl-CoA:Protein N-Myristoyltransferase Authors: Sogabe, S, Fukami, T.A, Morikami, K, Shiratori, Y, Aoki, Y, D'Arcy, A, Winkler, F.K, Banner, D.W, Ohtsuka, T. Deposit date: 2002-08-29 Release date: 2002-12-30 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors CHEM.BIOL., 9, 2002
1IID	Crystal Structure of Saccharomyces cerevisiae N-myristoyltransferase with Bound S-(2-oxo)pentadecylCoA and the Octapeptide GLYASKLA Descriptor: NICKEL (II) ION, Octapeptide GLYASKLA, Peptide N-myristoyltransferase, ... Authors: Farazi, T.A, Gordon, J.I, Waksman, G. Deposit date: 2001-04-22 Release date: 2001-05-02 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Biochemistry, 40, 2001
6TW5	Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-917 Descriptor: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Brannigan, J.A. Deposit date: 2020-01-12 Release date: 2021-07-21 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-917 To Be Published
6TW6	Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923 Descriptor: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Brannigan, J.A. Deposit date: 2020-01-12 Release date: 2021-07-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923 To Be Published
6TW7	Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918 Descriptor: Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, TETRADECANOYL-COA, ... Authors: Brannigan, J.A. Deposit date: 2020-01-12 Release date: 2021-07-21 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918 To Be Published
6TW8	Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917 Descriptor: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2020-01-12 Release date: 2021-07-21 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917 To Be Published
2P6E	Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA Descriptor: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA Authors: Wu, J, Ding, J. Deposit date: 2007-03-18 Release date: 2007-06-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. J.Biol.Chem., 282, 2007
2P6G	Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors Descriptor: 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA Authors: Wu, J, Ding, J. Deposit date: 2007-03-18 Release date: 2007-06-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. J.Biol.Chem., 282, 2007
2P6F	Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors Descriptor: (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA Authors: Wu, J, Ding, J. Deposit date: 2007-03-18 Release date: 2007-06-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. J.Biol.Chem., 282, 2007
5G1Z	Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 1) Descriptor: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Goncalves, V, Brannigan, J.A, Laporte, A, Bell, A.S, Roberts, S.M, Wilkinson, A.J, Leatherbarrow, R.J, Tate, E.W. Deposit date: 2016-04-06 Release date: 2017-02-15 Last modified: 2017-06-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm, 8, 2017
5G21	Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26). Descriptor: ETHYL 4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL), GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... Authors: Goncalves, V, Brannigan, J.A, Laporte, A, Bell, A.S, Roberts, S.M, Wilkinson, A.J, Leatherbarrow, R.J, Tate, E.W. Deposit date: 2016-04-06 Release date: 2017-02-15 Last modified: 2017-06-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm, 8, 2017

 

123456>