PDB: 47 resultsInfo pagesStatus searchChemie searchBIRD

---

5AXI	Crystal structure of Cbl-b TKB domain in complex with Cblin Descriptor: CALCIUM ION, CHLORIDE ION, Cblin, ... Authors: Ohno, A, Maita, N, Ochi, A, Nakao, R, Nikawa, T. Deposit date: 2015-07-29 Release date: 2016-03-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin Arch.Biochem.Biophys., 594, 2016
6XAR	Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2) Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Src-like-adapter 2 Authors: Wybenga-Groot, L.E, McGlade, C.J. Deposit date: 2020-06-04 Release date: 2021-03-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.501 Å) Cite: SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. J.Mol.Biol., 433, 2021
5O76	Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ... Authors: Gabrielsen, M, Buetow, L, Huang, D.T. Deposit date: 2017-06-08 Release date: 2017-11-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.473 Å) Cite: A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol. Cell, 68, 2017
7SIY	cCBL TKB domain in complex with pZAP70 peptide Descriptor: E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70 Authors: Murray, J.M, Yu, C. Deposit date: 2021-10-15 Release date: 2022-11-09 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.48 Å) Cite: cCBL TKB domain in complex with pZAP70 peptide To Be Published
1B47	STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70 Descriptor: CALCIUM ION, CBL Authors: Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. Deposit date: 1999-01-06 Release date: 1999-04-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
8GCY	Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor Descriptor: 1,2-ETHANEDIOL, 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, ... Authors: Kimani, S, Zeng, H, Dong, A, Li, Y, Santhakumar, V, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2023-03-03 Release date: 2023-03-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.81 Å) Cite: The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Commun Biol, 6, 2023
4GPL	Structure of Cbl(TKB) bound to a phosphorylated pentapeptide Descriptor: ACE-PTR-THR-PRO-GLU-PRO, PEPTIDE INHIBITOR, E3 ubiquitin-protein ligase CBL Authors: Borgstahl, G, Natarajan, A. Deposit date: 2012-08-21 Release date: 2013-09-18 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3 Å) Cite: The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides. Sci Rep, 3, 2013
1FBV	STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES Descriptor: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ... Authors: Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P. Deposit date: 2000-07-17 Release date: 2000-08-30 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell(Cambridge,Mass.), 102, 2000
6BK5	Inactive choanoflagellate E3 ubiquitin ligase Cbl TKB Descriptor: CALCIUM ION, Ubiquitin Ligase Cbl Authors: Amacher, J.F, Kuriyan, J. Deposit date: 2017-11-07 Release date: 2018-03-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.401 Å) Cite: Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates. Protein Sci., 27, 2018
6O02	Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL Descriptor: E3 ubiquitin-protein ligase CBL, Monobody (MC3) Authors: Kukenshoner, T, Pojer, F, Hantschel, O. Deposit date: 2019-02-15 Release date: 2020-08-19 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.953 Å) Cite: Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL To Be Published
1YVH	Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide Descriptor: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION Authors: Hu, J, Hubbard, S.R. Deposit date: 2005-02-15 Release date: 2005-03-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins J.Biol.Chem., 280, 2005
6O03	Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL Descriptor: E3 ubiquitin-protein ligase CBL, Monobody (MC17) Authors: Kukenshoner, T, Pojer, F, Hantschel, O. Deposit date: 2019-02-15 Release date: 2020-08-19 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Monobody (MC17) bound to tyrosine kinase binding domain of E3 ligase CBL To Be Published
2Y1M	Structure of native c-Cbl Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION Authors: Dou, H, Sibbet, G.J, Huang, D.T. Deposit date: 2010-12-08 Release date: 2012-01-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
2Y1N	Structure of c-Cbl-ZAP-70 peptide complex Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... Authors: Dou, H, Sibbet, G.J, Huang, D.T. Deposit date: 2010-12-08 Release date: 2012-01-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.999 Å) Cite: Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
2CBL	N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70 Descriptor: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70 Authors: Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. Deposit date: 1998-08-28 Release date: 1999-05-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
3ZNI	Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL-B, ... Authors: Dou, H, Buetow, L, Sibbet, G.J, Cameron, K, Huang, D.T. Deposit date: 2013-02-14 Release date: 2013-07-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3. Nat.Struct.Mol.Biol., 20, 2013
4A4B	Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... Authors: Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. Deposit date: 2011-10-08 Release date: 2012-01-25 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.789 Å) Cite: Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
4A4C	Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... Authors: Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. Deposit date: 2011-10-08 Release date: 2012-01-25 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.704 Å) Cite: Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
3BUN	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 Descriptor: 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL Authors: Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. Deposit date: 2008-01-03 Release date: 2008-02-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
3BUX	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met Descriptor: 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL Authors: Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. Deposit date: 2008-01-03 Release date: 2008-02-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
3BUM	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 Descriptor: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2 Authors: Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J. Deposit date: 2008-01-03 Release date: 2008-02-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
3BUW	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk Descriptor: 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL Authors: Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. Deposit date: 2008-01-03 Release date: 2008-02-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
3BUO	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' Descriptor: 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL Authors: Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. Deposit date: 2008-01-03 Release date: 2008-02-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
3OB1	Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide Descriptor: 12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL Authors: Sun, Q, Sivaraman, J. Deposit date: 2010-08-06 Release date: 2010-08-18 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain Plos One, 5, 2010
3OB2	Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide Descriptor: 12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL Authors: Sun, Q, Sivaraman, J. Deposit date: 2010-08-06 Release date: 2010-08-18 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain Plos One, 5, 2010

 

12>